BRPI0415179A - derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas - Google Patents

derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas

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Publication number
BRPI0415179A
BRPI0415179A BRPI0415179-8A BRPI0415179A BRPI0415179A BR PI0415179 A BRPI0415179 A BR PI0415179A BR PI0415179 A BRPI0415179 A BR PI0415179A BR PI0415179 A BRPI0415179 A BR PI0415179A
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Prior art keywords
pharmaceutical compositions
methods
ion channel
employing
amide derivatives
Prior art date
Application number
BRPI0415179-8A
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English (en)
Inventor
Ravindra B Upasani
Michael G Kelly
Satyanarayana Janagani
Original Assignee
Renovis Inc
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Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Publication of BRPI0415179A publication Critical patent/BRPI0415179A/pt

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Abstract

"DERIVADOS DE AMIDA COMO LIGANDOS DE CANAL DE ìON E COMPOSIçõES FARMACêUTICAS E MéTODOS DE EMPREGAR AS MESMAS". Descreve-se compostos que têm a fórmula representada pela seguinte: Fórmula (I) Os compostos podem ser preparados como composições farmacêuticas, e podem ser empregados para a prevenção e tratamento de diversas condições em mamíferos, incluindo humanos, incluindo por meio de exemplo não limitante, dor, inflamação, lesão traumática, e outros.
BRPI0415179-8A 2003-10-07 2004-10-07 derivados de amida como ligandos de canal de ìon e composições farmacêuticas e métodos de empregar as mesmas BRPI0415179A (pt)

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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432281B2 (en) 2003-10-07 2008-10-07 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20080300243A1 (en) * 2005-02-28 2008-12-04 Kelly Michael G Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
KR20070119655A (ko) * 2005-02-28 2007-12-20 레노비스, 인크. 이온-채널 리간드로서의 아미드 유도체, 및 이를 사용한제약 조성물 및 방법
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2006099410A2 (en) * 2005-03-14 2006-09-21 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
JP4754566B2 (ja) 2005-07-22 2011-08-24 持田製薬株式会社 新規なヘテロシクリデンアセトアミド誘導体
EP1764093A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764096A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
CA2641781A1 (en) * 2006-02-23 2007-09-07 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2007117465A2 (en) 2006-03-31 2007-10-18 Abbott Laboratories Indazole compounds
PE20081692A1 (es) 2007-01-24 2008-12-18 Mochida Pharm Co Ltd Nuevo derivado de heterocicliden acetamida
WO2008096755A1 (ja) * 2007-02-07 2008-08-14 Nippon Suisan Kaisha, Ltd. バニロイド受容体(vr1)阻害剤及びその用途
CN101686680B (zh) * 2007-03-09 2015-12-09 伊沃泰克美国股份有限公司 作为p2x7调节剂的双环杂芳基化合物及其用途
NZ581817A (en) * 2007-06-03 2012-05-25 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
JP2009108036A (ja) * 2007-09-28 2009-05-21 Fujifilm Corp 新規アセチレン化合物、その製造方法、それを構成単位として含むポリマー、該化合物及び/又は該ポリマーを含む組成物、該組成物を硬化させてなる硬化物
CN101906056B (zh) * 2009-06-04 2013-10-30 中国科学院广州生物医药与健康研究院 作为m2抑制剂的环烷胺类化合物及其应用
US9452980B2 (en) * 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
MY157429A (en) * 2011-06-24 2016-06-15 Amgen Inc Trpm8 antagonists and their use in treatments
WO2013078413A1 (en) * 2011-11-22 2013-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Modulators of lipid storage
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
MY195528A (en) 2016-03-17 2023-01-30 Hoffmann La Roche 5-Ethyl-4-Methyl-Pyrazole-3-Carboxamide Derivative Having Activity as Agonist of Taar
CN108503899B (zh) * 2018-05-28 2020-05-22 深圳先进技术研究院 前列腺仿体及其制备方法与应用
JP2021534084A (ja) * 2018-08-06 2021-12-09 ダナ−ファーバー キャンサー インスティテュート,インコーポレイテッド ヒストンデメチラーゼ5阻害剤およびその使用
WO2021222637A1 (en) 2020-04-30 2021-11-04 United States Government As Represented By The Department Of Veterans Affairs Krüppel-like factor 15 (klf15) small molecule agonists in kidney disease
US20240252665A1 (en) * 2021-06-02 2024-08-01 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Chemical coupling linker and use thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3346584A (en) 1964-09-23 1967-10-10 Union Carbide Corp 2-polychloroalkylbenzothiazolines
US3424761A (en) * 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
US3424760A (en) * 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
NO133758C (pt) 1970-04-04 1976-06-23 Takeda Chemical Industries Ltd
GB2058047B (en) 1979-07-11 1983-09-21 Asahi Chemical Ind Amides and amidines
JPS5612352A (en) * 1979-07-11 1981-02-06 Asahi Chem Ind Co Ltd Ai-77, medically permissible salt thereof and their preparation
JPS58105229A (ja) 1981-12-18 1983-06-23 Fuji Photo Film Co Ltd カラ−写真感光材料
US4760161A (en) 1983-04-25 1988-07-26 Merck & Co., Inc. Ipoxygenase inhibitors
US4579866A (en) 1984-05-29 1986-04-01 Usv Pharmaceutical Corp. Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
FR2567887B1 (fr) 1984-07-19 1986-12-19 Rhone Poulenc Sante Nouveaux amides substitues, leur preparation et les medicaments qui les contiennent
GB9125924D0 (en) 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative
ES2092729T3 (es) 1992-07-01 1996-12-01 Hoechst Ag Benzoilguanidinas 3,4,5-sustituidas, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
HUP9801630A2 (hu) 1995-04-08 1998-11-30 Basf Aktiengesellschaft Kinolinszármazékokból és citokróm B/C inhibitorokból készített szinergikus fungicid készítmények
IT1277597B1 (it) 1995-09-15 1997-11-11 Smithkline Beecham Spa Derivati di diarilalchenilammina
EP0876345B1 (en) 1995-10-16 2004-08-18 Fujisawa Pharmaceutical Co., Ltd. Heterocyclic compounds as h+-atpases
US6221865B1 (en) 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
JP3285746B2 (ja) * 1995-11-24 2002-05-27 株式会社資生堂 フェニレンジアミン誘導体及びラジカルスカベンジャー、脳梗塞抑制剤、脳浮腫抑制剤
AU1618697A (en) 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
JPH10265452A (ja) 1996-05-24 1998-10-06 Ono Pharmaceut Co Ltd フェニルスルホンアミド誘導体
WO1997048694A1 (en) 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
EP0975603A1 (en) 1997-01-29 2000-02-02 Zeneca Limited Inhibitors of farnesyl protein transferase
AU7371998A (en) 1997-05-07 1998-11-27 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
TW544448B (en) 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
JPH11171848A (ja) * 1997-09-26 1999-06-29 Fujirebio Inc 芳香族アミド誘導体
US6555584B1 (en) * 2000-06-29 2003-04-29 Ajinomoto Co., Inc. Acylsulfonamide derivative
WO1999018105A1 (en) * 1997-10-07 1999-04-15 Ortho-Mcneil Pharmaceutical, Inc. Dipyridoimidazolderivatives useful in treating central nervous system disorders
JP3337992B2 (ja) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 5−置換ピコリン酸化合物及びその製造方法
EP1054865A1 (en) 1998-02-10 2000-11-29 AstraZeneca UK Limited Farnesyl transferase inhibitors
HUP0101275A3 (en) 1998-03-26 2002-12-28 Japan Tobacco Inc Amide derivatives and pharmaceutical compositions containing them as nociceptin antagonists
CA2332957A1 (en) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
WO2000015213A1 (en) 1998-09-11 2000-03-23 Shionogi & Co., Ltd. Remedal or preventive agent for congestive heart failure
US6331640B1 (en) 1998-10-13 2001-12-18 Hoffmann-La Roche Inc. Diaminopropionic acid derivatives
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
AU1872900A (en) 1998-12-23 2000-07-31 Astrazeneca Ab Chemical compounds
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
JP2003503350A (ja) * 1999-06-30 2003-01-28 第一製薬株式会社 Vla−4インヒビター化合物
JP2003506387A (ja) 1999-08-04 2003-02-18 アイカゲン インコーポレイテッド カリウムチャンネルオープナーとしてのベンズアニリド
NZ527771A (en) 1999-08-04 2005-04-29 Icagen Inc Methods for treating or preventing anxiety
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
JP2003509412A (ja) 1999-09-17 2003-03-11 シーオーアール セラピューティクス インコーポレイテッド Xa因子阻害剤
WO2001021615A1 (fr) * 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Dérivés de benzimidazole
WO2001021160A2 (en) 1999-09-23 2001-03-29 Axxima Pharmaceuticals Aktiengesellschaft Carboxymide and aniline derivatives as selective inhibitors of pathogens
ATE312100T1 (de) * 1999-09-28 2005-12-15 Eisai Co Ltd Chinuclidin-verbindungen und medikamente die diese als aktive wirkstoffe enthalten
JP5278983B2 (ja) 1999-11-17 2013-09-04 塩野義製薬株式会社 アミド化合物の新規用途
WO2001051456A2 (en) 2000-01-13 2001-07-19 Tularik Inc. Antibacterial agents
AU2001231143A1 (en) 2000-01-27 2001-08-07 Cytovia, Inc. Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof
ES2254385T3 (es) 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
WO2001082916A2 (en) 2000-05-03 2001-11-08 Tularik Inc. Combination therapeutic compositions and methods of use
JP2002055409A (ja) 2000-08-08 2002-02-20 Fuji Photo Film Co Ltd 熱現像感光材料
JP2004523490A (ja) 2000-11-28 2004-08-05 ギルフォード ファーマシュウティカルズ インコーポレイテッド 二置換カルボサイクリックサイクロフィリン結合化合物とその用途
US7132546B2 (en) 2000-12-22 2006-11-07 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
WO2002053101A2 (en) 2000-12-29 2002-07-11 Alteon, Inc. Method for treating fibrotic diseases or other indications
MXPA03006666A (es) 2001-01-25 2004-05-31 Guilford Pharm Inc Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
WO2002094766A1 (en) 2001-05-18 2002-11-28 Nihon Nohyaku Co., Ltd. Phthalamide derivative, agricultural or horticultural insecticide, and use thereof
DE10154689A1 (de) 2001-11-09 2003-05-22 Probiodrug Ag Substituierte Aminoketonverbindungen
NZ531153A (en) 2001-08-09 2005-10-28 Ono Pharmaceutical Co Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
US20030130343A1 (en) 2001-08-10 2003-07-10 Adipogenix, Inc. Fat accumulation-modulating compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
AUPR738301A0 (en) 2001-08-30 2001-09-20 Starpharma Limited Chemotherapeutic agents
US7429593B2 (en) 2001-09-14 2008-09-30 Shionogi & Co., Ltd. Utilities of amide compounds
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
WO2003024448A2 (en) 2001-09-14 2003-03-27 Methylgene, Inc. Inhibitors of histone deacetylase
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US20040157919A1 (en) 2002-01-25 2004-08-12 Yong-Qian Wu Trisubstituted carbocyclic cyclophilin binding compounds and their use
AR038420A1 (es) 2002-02-15 2005-01-12 Glaxo Group Ltd Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende
AU2003243921B2 (en) 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
AU2003249983A1 (en) 2002-07-18 2004-02-09 Actelion Pharmaceuticals Ltd Piperidines useful for the treatment of central nervous system disorders
US20040110802A1 (en) 2002-08-23 2004-06-10 Atli Thorarensen Antibacterial benzoic acid derivatives
DE10238865A1 (de) * 2002-08-24 2004-03-11 Boehringer Ingelheim International Gmbh Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU2003263393A1 (en) 2002-09-04 2004-03-29 Glenmark Pharmaceuticals Limited New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
EP1551795A1 (en) 2002-10-17 2005-07-13 Methylgene, Inc. Inhibitors of histone deacetylase
WO2004063179A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Substituted arylcyclopropylacetamides as glucokinase activators
SG159388A1 (en) * 2003-01-08 2010-03-30 Chiron Corp Antibacterial agents
TW200505450A (en) 2003-02-03 2005-02-16 Janssen Pharmaceutica Nv Quinoline-derived amide modulators of vanilloid VR1 receptor
ZA200507486B (en) 2003-03-07 2007-03-28 Astellas Pharma Inc Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl
AR045979A1 (es) 2003-04-28 2005-11-23 Astrazeneca Ab Amidas heterociclicas
CA2532064A1 (en) 2003-07-15 2005-02-03 Merck & Co., Inc. Hydroxypyridine cgrp receptor antagonists
JP2007502291A (ja) 2003-08-12 2007-02-08 アムジエン・インコーポレーテツド アリールスルホンアミドベンジル系化合物
WO2005019176A1 (en) 2003-08-25 2005-03-03 Actelion Pharmaceuticals Ltd Substituted amino-aza-cyclohexanes
EP1669348A4 (en) * 2003-09-30 2009-03-11 Eisai R&D Man Co Ltd NEW ANTIPILIC AGENT CONTAINING A HETEROCYCLIC COMPOUND
US7432281B2 (en) * 2003-10-07 2008-10-07 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2005072681A2 (en) 2004-01-23 2005-08-11 Amgen Inc. Vanilloid receptor ligands and their use in treatments of inflammatory and neurotic pain.
JP2005314347A (ja) 2004-04-30 2005-11-10 Japan Tobacco Inc 疼痛抑制剤
TW200602314A (en) 2004-05-28 2006-01-16 Tanabe Seiyaku Co A novel pyrrolidine compound and a process for preparing the same
US20060035939A1 (en) * 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
US20080300243A1 (en) * 2005-02-28 2008-12-04 Kelly Michael G Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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TW200526631A (en) 2005-08-16
JP4667384B2 (ja) 2011-04-13
JP2007509043A (ja) 2007-04-12
EP1680109A1 (en) 2006-07-19

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