BRPI0709581A8 - compostos de bicicloeteroarila como moduladores de px27 e seu uso - Google Patents

compostos de bicicloeteroarila como moduladores de px27 e seu uso

Info

Publication number
BRPI0709581A8
BRPI0709581A8 BRPI0709581A BRPI0709581A BRPI0709581A8 BR PI0709581 A8 BRPI0709581 A8 BR PI0709581A8 BR PI0709581 A BRPI0709581 A BR PI0709581A BR PI0709581 A BRPI0709581 A BR PI0709581A BR PI0709581 A8 BRPI0709581 A8 BR PI0709581A8
Authority
BR
Brazil
Prior art keywords
compounds
bicycloetheroyl
modulators
inflammation
pain
Prior art date
Application number
BRPI0709581A
Other languages
English (en)
Inventor
Kaub Carl
Kincaid John
G Kelly Michael
Gowlugari Sumithra
Cao Yeyu
Fang Yunfeng
Wang Zhan
Original Assignee
Evotec Us Inc
Renovis Inc
Second Genome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Us Inc, Renovis Inc, Second Genome Inc filed Critical Evotec Us Inc
Publication of BRPI0709581A2 publication Critical patent/BRPI0709581A2/pt
Publication of BRPI0709581A8 publication Critical patent/BRPI0709581A8/pt

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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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  • Cardiology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

<b>compostos de bicicloeteroarila como moduladores de px2~ 7~ e seu uso.<d> compostos de bicicloeteroarila são descritas os quais possuem uma fórmula representada pela seguinte fórmula (i): os compostos podem ser preparados como composições farmacêuticas, e podem ser usados para a prevenção e tratamento de uma variedade de condições em mamíferos incluindo seres humanos, abrangendo por meio de exemplo não-limitativo, dor, inflamação, lesão traumática, e outros.
BRPI0709581A 2006-03-16 2007-03-16 compostos de bicicloeteroarila como moduladores de px27 e seu uso BRPI0709581A8 (pt)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US78292306P 2006-03-16 2006-03-16
US78312106P 2006-03-16 2006-03-16
US78359006P 2006-03-16 2006-03-16
US60/782,923 2006-03-16
US60/783,121 2006-03-16
US60/783,590 2006-03-16
US83141606P 2006-07-17 2006-07-17
US60/831,416 2006-07-17
US90604907P 2007-03-09 2007-03-09
PCT/US2007/006735 WO2007109192A2 (en) 2006-03-16 2007-03-16 Bicycloheteroaryl compounds as p2x7 modulators and uses thereof

Publications (2)

Publication Number Publication Date
BRPI0709581A2 BRPI0709581A2 (pt) 2011-07-19
BRPI0709581A8 true BRPI0709581A8 (pt) 2018-12-11

Family

ID=38523012

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0709581A BRPI0709581A8 (pt) 2006-03-16 2007-03-16 compostos de bicicloeteroarila como moduladores de px27 e seu uso

Country Status (12)

Country Link
US (2) US7816371B2 (pt)
EP (1) EP1933622B1 (pt)
JP (1) JP5240941B2 (pt)
CN (1) CN101442909B (pt)
AR (1) AR059920A1 (pt)
BR (1) BRPI0709581A8 (pt)
CA (1) CA2645568C (pt)
DK (1) DK1933622T3 (pt)
ES (1) ES2569352T3 (pt)
MX (1) MX2008011922A (pt)
TW (1) TWI464148B (pt)
WO (1) WO2007109192A2 (pt)

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KR102222220B1 (ko) 2013-01-22 2021-03-03 이도르시아 파마슈티컬스 리미티드 Ｐ2ｘ7 수용체 길항제로서의 헤테로시클릭 아미드 유도체
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WO2019099509A1 (en) * 2017-11-14 2019-05-23 Second Genome, Inc. Use of a p2x7 receptor antagonist to treat an inflammatory disease or disorder
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HUE073311T2 (hu) 2020-03-31 2026-01-28 Remicine Ip B V Hiperinflammatorikus szindróma kezelése
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TWI825637B (zh) 2021-03-31 2023-12-11 美商輝瑞股份有限公司 啶－１，６（２ｈ，７ｈ）－二酮
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EP1933622A2 (en) 2008-06-25
US20070225324A1 (en) 2007-09-27
WO2007109192A2 (en) 2007-09-27
AR059920A1 (es) 2008-05-07
CN101442909A (zh) 2009-05-27
US7816371B2 (en) 2010-10-19
CA2645568C (en) 2014-11-18
WO2007109192A3 (en) 2007-11-22
JP2009530304A (ja) 2009-08-27
HK1133787A1 (en) 2010-04-09
MX2008011922A (es) 2008-11-28
JP5240941B2 (ja) 2013-07-17
TWI464148B (zh) 2014-12-11
EP1933622A4 (en) 2010-03-10
TW200800904A (en) 2008-01-01
CN101442909B (zh) 2013-03-27
EP1933622B1 (en) 2016-03-09
DK1933622T3 (en) 2016-05-02
CA2645568A1 (en) 2007-09-27
US20110092476A1 (en) 2011-04-21
BRPI0709581A2 (pt) 2011-07-19

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