BRPI0506535A - pirroles bis-indole úteis como agentes anti-microbiais - Google Patents

pirroles bis-indole úteis como agentes anti-microbiais

Info

Publication number
BRPI0506535A
BRPI0506535A BRPI0506535-6A BRPI0506535A BRPI0506535A BR PI0506535 A BRPI0506535 A BR PI0506535A BR PI0506535 A BRPI0506535 A BR PI0506535A BR PI0506535 A BRPI0506535 A BR PI0506535A
Authority
BR
Brazil
Prior art keywords
disclosed
compounds
bisindole
antimicrobial agents
pyrroles
Prior art date
Application number
BRPI0506535-6A
Other languages
English (en)
Inventor
Scott S Mitchell
Kin S Lam
Barbara C Potts
Ginger Tsueng
Jennifer Grodberg
Donald J White
Katherine Anne Reed
Original Assignee
Nereus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc filed Critical Nereus Pharmaceuticals Inc
Publication of BRPI0506535A publication Critical patent/BRPI0506535A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"PIRROLES BIS-INDOLE úTEIS COMO AGENTES ANTI-MICROBIAIS". São descritos compostos da Fórmula (I), comumente chamados de pirroles bis-indole, incluindo compostos isolados que ocorrem naturalmente, seus derivados sintéticos e semi-sintéticos tendo propriedades anti-microbiais, e composições anti-microbiais incluindo um ou mais pirroles bis-indole e seus derivados ou análogos tendo propriedades anti-microbiais. Composições farmacêuticas compreendendo tais compostos e métodos de tratamento de infecções bacterianas com os ditos compostos descritos ou com as ditas composições farmacêuticas também são descritos.
BRPI0506535-6A 2004-01-23 2005-01-21 pirroles bis-indole úteis como agentes anti-microbiais BRPI0506535A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53905304P 2004-01-23 2004-01-23
US62723504P 2004-11-12 2004-11-12
PCT/US2005/002039 WO2005070922A2 (en) 2004-01-23 2005-01-21 Bis-indole pyrroles useful as antimicrobials agents

Publications (1)

Publication Number Publication Date
BRPI0506535A true BRPI0506535A (pt) 2007-02-27

Family

ID=34811361

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506535-6A BRPI0506535A (pt) 2004-01-23 2005-01-21 pirroles bis-indole úteis como agentes anti-microbiais

Country Status (9)

Country Link
US (2) US7166634B2 (pt)
EP (1) EP1711486B1 (pt)
JP (1) JP2007519727A (pt)
KR (1) KR20060132698A (pt)
AT (1) ATE509018T1 (pt)
AU (1) AU2005206560A1 (pt)
BR (1) BRPI0506535A (pt)
CA (1) CA2552350A1 (pt)
WO (1) WO2005070922A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0506535A (pt) 2004-01-23 2007-02-27 Nereus Pharmaceuticals Inc pirroles bis-indole úteis como agentes anti-microbiais
US8956669B2 (en) * 2009-02-19 2015-02-17 The Uab Research Foundation Anticancer and antimicrobial compounds from antarctic extremophilic microorgansims
US20110008469A1 (en) * 2009-07-09 2011-01-13 Florida Gulf Coast University Antimicrobial composition and methods and apparatus for use thereof
WO2013040528A1 (en) * 2011-09-16 2013-03-21 Microbiotix, Inc. Antimicrobial compounds
WO2013040526A1 (en) * 2011-09-16 2013-03-21 Microbiotix, Inc. Antimicrobial compounds
WO2013040527A1 (en) * 2011-09-16 2013-03-21 Microbiotix, Inc. Antimicrobial compounds
WO2014078294A1 (en) * 2012-11-13 2014-05-22 Memorial Sloan-Kettering Cancer Center Indole compounds and their use as antimicrobials
EP3301096A1 (en) * 2016-09-30 2018-04-04 Heinrich-Heine-Universität Düsseldorf Bis-indole derivatives for use in the treatment of bacterial infections

Family Cites Families (30)

* Cited by examiner, † Cited by third party
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US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5276182A (en) * 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) * 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5653962A (en) * 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
AU5612694A (en) * 1992-11-27 1994-06-22 Napro Biotherapeutics, Inc. Injectable composition
JPH06247964A (ja) * 1993-02-22 1994-09-06 Snow Brand Milk Prod Co Ltd 新規生理活性物質ｈｓ−１及びその製造方法
US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
EP1475091A1 (en) * 1993-10-01 2004-11-10 Roche Palo Alto LLC Mycophenolate mofetil - high dose oral suspensions
US5707641A (en) * 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) * 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) * 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) * 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5874443A (en) * 1995-10-19 1999-02-23 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
US5886210A (en) * 1996-08-22 1999-03-23 Rohm And Haas Company Method for preparing aromatic compounds
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
EP1032377B1 (en) * 1997-11-21 2010-11-17 Purdue Neuroscience Company Substituted 2-aminoacetamides and the use thereof
AU2548699A (en) 1998-02-23 1999-09-06 Rei Asakai Cell death inhibitors
BR9909146A (pt) * 1998-03-26 2000-12-05 Shionogi & Co Derivados de indol apresentando uma atividade antiviral
US6509331B1 (en) * 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
FR2784988B1 (fr) 1998-10-23 2002-09-20 Adir Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000033836A1 (en) 1998-12-04 2000-06-15 Ontogen Corporation 5-membered heterocycles for the treatment of human diseases involving modulators of selectins
EP1152002A4 (en) * 1999-02-09 2002-04-17 Sagami Chem Res PYRROL DERIVATIVES AND CELL DEATH INHIBITORS
US6569830B1 (en) * 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
EP1341926A2 (en) 2000-11-14 2003-09-10 Phibro-Tech, Inc., doing business as Agtrol International Novel nucleic acids, methods and transformed cells for the modulation of gibberellin production
WO2002057254A1 (en) 2001-01-18 2002-07-25 Sankyo Company, Limited Compositions for prevention or treatment of hepatopathy
DE10109280A1 (de) * 2001-02-26 2002-09-05 Peter Mayser Indolderivate mit inhibitorischer Wirkung auf Proteinkinasen
BRPI0506535A (pt) * 2004-01-23 2007-02-27 Nereus Pharmaceuticals Inc pirroles bis-indole úteis como agentes anti-microbiais

Also Published As

Publication number Publication date
ATE509018T1 (de) 2011-05-15
AU2005206560A1 (en) 2005-08-04
CA2552350A1 (en) 2005-08-04
US7375129B2 (en) 2008-05-20
EP1711486A2 (en) 2006-10-18
US7166634B2 (en) 2007-01-23
US20070149601A1 (en) 2007-06-28
US20050267192A1 (en) 2005-12-01
EP1711486B1 (en) 2011-05-11
KR20060132698A (ko) 2006-12-21
WO2005070922A3 (en) 2005-09-09
JP2007519727A (ja) 2007-07-19
WO2005070922A2 (en) 2005-08-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2205 DE 09/04/2013.