BRPI0506883A - miméticos de smac conformacionalmente comprimidos e seus usos - Google Patents

miméticos de smac conformacionalmente comprimidos e seus usos

Info

Publication number
BRPI0506883A
BRPI0506883A BRPI0506883-5A BRPI0506883A BRPI0506883A BR PI0506883 A BRPI0506883 A BR PI0506883A BR PI0506883 A BRPI0506883 A BR PI0506883A BR PI0506883 A BRPI0506883 A BR PI0506883A
Authority
BR
Brazil
Prior art keywords
compressed
smac mimetics
conformational
mimetics
smac
Prior art date
Application number
BRPI0506883-5A
Other languages
English (en)
Inventor
Shaomeng Wang
Haiying Sun
Zaneta Nikolovska-Coleska
Chao-Yie Yang
Liang Xu
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of BRPI0506883A publication Critical patent/BRPI0506883A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

MIMéTICOS DE SMAC CONFORMACIONALMENTE COMPRIMIDOS E SEUS USOS A invenção refere-se a miméticos de Smac conformacionalmente comprimidos que funcionam como inibidores de Proteínas Inibidoras de Apoptose. A invenção também se refere ao uso destes miméticos para indução de morte celular apoptótica e para sensibilizar células indutoras de apoptose.
BRPI0506883-5A 2004-01-16 2005-01-18 miméticos de smac conformacionalmente comprimidos e seus usos BRPI0506883A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53714004P 2004-01-16 2004-01-16
PCT/US2005/001406 WO2005069894A2 (en) 2004-01-16 2005-01-18 Conformationally constrained smac mimetics and the uses thereof

Publications (1)

Publication Number Publication Date
BRPI0506883A true BRPI0506883A (pt) 2007-05-29

Family

ID=34807084

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506883-5A BRPI0506883A (pt) 2004-01-16 2005-01-18 miméticos de smac conformacionalmente comprimidos e seus usos

Country Status (9)

Country Link
US (1) US7932382B2 (pt)
EP (1) EP1718300A4 (pt)
JP (1) JP2007522116A (pt)
CN (1) CN1960728A (pt)
AU (1) AU2005206929B2 (pt)
BR (1) BRPI0506883A (pt)
CA (1) CA2553874A1 (pt)
MX (1) MXPA06008095A (pt)
WO (1) WO2005069894A2 (pt)

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US8202902B2 (en) 2006-05-05 2012-06-19 The Regents Of The University Of Michigan Bivalent SMAC mimetics and the uses thereof
NZ572531A (en) 2006-05-05 2011-09-30 Univ Michigan Bivalent smac mimetics and the uses thereof
WO2008014229A2 (en) * 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
MX2009000824A (es) 2006-07-24 2009-02-04 Tetralogic Pharmaceuticals Cor Antagonistas dimericos de las proteinas inhibidoras de la apoptosis.
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WO2008128171A2 (en) 2007-04-13 2008-10-23 The Regents Of The University Of Michigan Diazo bicyclic smac mimetics and the uses thereof
WO2008134679A1 (en) 2007-04-30 2008-11-06 Genentech, Inc. Inhibitors of iap
JP2010528587A (ja) * 2007-05-07 2010-08-26 テトラロジック ファーマシューティカルズ コーポレーション アポトーシス阻害タンパク質のアンタゴニストに対する感受性のバイオマーカーとしてＴＮＦα遺伝子の発現を用いる方法
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Also Published As

Publication number Publication date
JP2007522116A (ja) 2007-08-09
AU2005206929B2 (en) 2008-01-24
WO2005069894A2 (en) 2005-08-04
MXPA06008095A (es) 2007-03-28
EP1718300A4 (en) 2008-05-14
CN1960728A (zh) 2007-05-09
AU2005206929A1 (en) 2005-08-04
WO2005069894A3 (en) 2005-10-06
CA2553874A1 (en) 2005-08-04
EP1718300A2 (en) 2006-11-08
US20080269140A1 (en) 2008-10-30
US7932382B2 (en) 2011-04-26
WO2005069894A8 (en) 2007-01-04

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