ECSP088377A - Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas - Google Patents

Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas

Info

Publication number
ECSP088377A
ECSP088377A EC2008008377A ECSP088377A ECSP088377A EC SP088377 A ECSP088377 A EC SP088377A EC 2008008377 A EC2008008377 A EC 2008008377A EC SP088377 A ECSP088377 A EC SP088377A EC SP088377 A ECSP088377 A EC SP088377A
Authority
EC
Ecuador
Prior art keywords
derivatives
carbamoilbenzotriazol
phospholipases
lipases
inhibitors
Prior art date
Application number
EC2008008377A
Other languages
English (en)
Inventor
Stefan Petry
Norbert Tennagels
Gerhard Zoller
Guenter Mueller
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ECSP088377A publication Critical patent/ECSP088377A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La invención se refiere a derivados de benzotriazol de la fórmula general (I) con los significados indicados en la descripción, a sus sales de uso farmacéutico y a su uso como medicamentos. (I)
EC2008008377A 2005-10-19 2008-04-17 Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas ECSP088377A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005049953A DE102005049953A1 (de) 2005-10-19 2005-10-19 Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number Publication Date
ECSP088377A true ECSP088377A (es) 2008-05-30

Family

ID=37667178

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008377A ECSP088377A (es) 2005-10-19 2008-04-17 Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas

Country Status (26)

Country Link
US (2) US7897625B2 (es)
EP (1) EP1940807B1 (es)
JP (1) JP2009512650A (es)
KR (1) KR20080063474A (es)
CN (1) CN101291918A (es)
AR (1) AR057554A1 (es)
AU (1) AU2006303552A1 (es)
BR (1) BRPI0617613A2 (es)
CA (1) CA2625722A1 (es)
CR (1) CR9850A (es)
DE (1) DE102005049953A1 (es)
DO (1) DOP2006000226A (es)
EC (1) ECSP088377A (es)
GT (1) GT200600463A (es)
HN (1) HN2006035238A (es)
IL (1) IL190714A0 (es)
MA (1) MA29858B1 (es)
NO (1) NO20081942L (es)
NZ (1) NZ567573A (es)
PE (1) PE20070724A1 (es)
RU (1) RU2430096C2 (es)
TN (1) TNSN08177A1 (es)
TW (1) TW200730513A (es)
UY (1) UY29872A1 (es)
WO (1) WO2007045393A1 (es)
ZA (1) ZA200802370B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541782A (zh) * 2006-10-04 2009-09-23 先灵公司 作为凝血酶受体拮抗剂的二环和三环衍生物
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
US8957219B2 (en) 2008-10-17 2015-02-17 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on endothelial lipase
MX342128B (es) * 2008-12-24 2016-09-14 Bial - Portela & C A S A Compuestos farmaceuticos.
US8975286B2 (en) * 2009-08-20 2015-03-10 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
KR20120123325A (ko) 2009-12-15 2012-11-08 시오노기세야쿠 가부시키가이샤 혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
US8450350B2 (en) * 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
CA2812593A1 (en) * 2010-09-27 2012-04-12 Janssen Pharmaceutica Nv Alpha-ketoamide derivatives useful endothelial lipase inhibitors
RS57962B1 (sr) * 2013-02-25 2019-01-31 Aurigene Discovery Tech Ltd Derivati trisupstituisanog benzotriazola kao inhibitori dihidroorotat oksigenaze
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2553987C1 (ru) * 2013-12-26 2015-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения
CN104292172B (zh) * 2014-09-12 2016-08-17 浙江理工大学 一种苯并三氮唑类衍生物及其制备方法
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
HRP20211462T1 (hr) 2017-04-24 2021-12-24 Aurigene Discovery Technologies Limited Postupci uporabe za trisupstituirane derivate benzotriazola kao inhibitora dihidroorotatne oksigenaze
TWI818954B (zh) 2018-02-20 2023-10-21 法商施維雅藥廠 三取代之苯并三唑衍生物的使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1035188A (en) * 1974-08-15 1978-07-25 Eastman Kodak Company Blocked development restrainers
US4273860A (en) * 1977-12-28 1981-06-16 Eastman Kodak Company Inhibition of image formation utilizing cobalt(III) complexes
CA1124716A (en) 1978-10-20 1982-06-01 Michael J. Simons Blocked benzotriazole compounds as development restrainer precursors
JPS6239573A (ja) * 1985-08-13 1987-02-20 Sumitomo Chem Co Ltd シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤
US6440648B1 (en) * 2000-06-13 2002-08-27 Eastman Kodak Company Color photographic element having improved contrast and compatibility with both dry and conventional processing
US6372421B1 (en) * 2000-06-13 2002-04-16 Eastman Kodak Company Photothermographic imaging element having improved contrast and methods of image formation
WO2002090355A1 (en) 2001-05-05 2002-11-14 Smithkline Beecham P.L.C. N-aroyl cyclic amines
EP1458374A2 (en) 2001-12-14 2004-09-22 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
DE10247680B4 (de) * 2002-10-12 2005-09-01 Aventis Pharma Deutschland Gmbh Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
DE602004023062D1 (en) * 2003-03-31 2009-10-22 Lilly Co Eli 3-oxo-1,3-dihydro-indazol-2-carbonsäureamid derivate als phospholipase inhibitoren

Also Published As

Publication number Publication date
BRPI0617613A2 (pt) 2011-08-02
PE20070724A1 (es) 2007-08-07
EP1940807B1 (de) 2015-06-17
RU2008119460A (ru) 2009-11-27
NO20081942L (no) 2008-04-23
CA2625722A1 (en) 2007-04-26
US20080287503A1 (en) 2008-11-20
US7897625B2 (en) 2011-03-01
JP2009512650A (ja) 2009-03-26
TNSN08177A1 (en) 2009-10-30
KR20080063474A (ko) 2008-07-04
WO2007045393A1 (de) 2007-04-26
ZA200802370B (en) 2008-12-31
HN2006035238A (es) 2010-05-24
DE102005049953A1 (de) 2007-04-26
NZ567573A (en) 2010-06-25
TW200730513A (en) 2007-08-16
GT200600463A (es) 2007-05-21
US20110118321A1 (en) 2011-05-19
CN101291918A (zh) 2008-10-22
MA29858B1 (fr) 2008-10-03
DOP2006000226A (es) 2007-05-15
CR9850A (es) 2008-06-18
AU2006303552A1 (en) 2007-04-26
RU2430096C2 (ru) 2011-09-27
IL190714A0 (en) 2008-11-03
EP1940807A1 (de) 2008-07-09
UY29872A1 (es) 2007-05-31
AR057554A1 (es) 2007-12-05

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