BRPI0506983A - composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico - Google Patents

composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico

Info

Publication number
BRPI0506983A
BRPI0506983A BRPI0506983-1A BRPI0506983A BRPI0506983A BR PI0506983 A BRPI0506983 A BR PI0506983A BR PI0506983 A BRPI0506983 A BR PI0506983A BR PI0506983 A BRPI0506983 A BR PI0506983A
Authority
BR
Brazil
Prior art keywords
particles
hyaluronic acid
compositions
triamcinolone acetonide
nanometers
Prior art date
Application number
BRPI0506983-1A
Other languages
English (en)
Inventor
Patrick M Hughes
Orest Olejnik
Scott M Whitcup
James A Burke
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0506983A publication Critical patent/BRPI0506983A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSIçõES PARA TERAPIA LOCALIZADA DOS OLHOS, COMPREENDENDO PREFERENCIALMENTE ACETONIDA DE TRIANCINOLONA E áCIDO HIALURÈNICO. A presente invenção refere-sas a composições, e métodos para usar as composições referidas, úteis para injeção dentro dos segmentos posteriores de olhos humanos ou animais. As composições referidas incluem pequenas partículas de um agente terapêutico fracamente solúvel que facilita a formação de regiões concentradas do agente terapêutico no epitélio pigmentado da retina de um olho. As partículas são formadas combinando um agente terapêutico com um componente polimérico oftalmicamente aceitável. As partículas têm medidas menores do que cerca de 3000 nanómetros, e em alguns casos, menores do que cerca de 200 nanómetros. Um exemplo de uma composição inclui partículas de acetonida de triancinolona e ácido hialurónico tendo uma medida menor do que cerca de 3000 nanómetros.
BRPI0506983-1A 2004-01-20 2005-01-14 composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico BRPI0506983A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53762004P 2004-01-20 2004-01-20
PCT/US2005/001371 WO2005072701A1 (en) 2004-01-20 2005-01-14 Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid

Publications (1)

Publication Number Publication Date
BRPI0506983A true BRPI0506983A (pt) 2007-07-03

Family

ID=34825933

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0506983-1A BRPI0506983A (pt) 2004-01-20 2005-01-14 composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico

Country Status (12)

Country Link
US (3) US20050181017A1 (pt)
EP (1) EP1706095B1 (pt)
JP (3) JP2007518804A (pt)
CN (1) CN100548271C (pt)
AT (1) ATE418325T1 (pt)
AU (2) AU2005209201B2 (pt)
BR (1) BRPI0506983A (pt)
CA (1) CA2553381C (pt)
DE (1) DE602005011928D1 (pt)
ES (1) ES2318453T3 (pt)
TW (1) TWI366471B (pt)
WO (1) WO2005072701A1 (pt)

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AU2005209201B2 (en) 2010-06-03

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