BRPI0507048A - uso de baixa dosagem de eritropoetina para estimular células precursoras endoteliais, regenerar órgãos e retardar a progressão de danos em órgão alvo - Google Patents

uso de baixa dosagem de eritropoetina para estimular células precursoras endoteliais, regenerar órgãos e retardar a progressão de danos em órgão alvo

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Publication number
BRPI0507048A
BRPI0507048A BRPI0507048-1A BRPI0507048A BRPI0507048A BR PI0507048 A BRPI0507048 A BR PI0507048A BR PI0507048 A BRPI0507048 A BR PI0507048A BR PI0507048 A BRPI0507048 A BR PI0507048A
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BR
Brazil
Prior art keywords
precursor cells
endothelial precursor
low
target organ
organ damage
Prior art date
Application number
BRPI0507048-1A
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English (en)
Inventor
Ferdinand Hermann Bahlmann
Hermann Haller
Original Assignee
Epoplus Gmbh & Co Kg
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Publication date
Application filed by Epoplus Gmbh & Co Kg filed Critical Epoplus Gmbh & Co Kg
Publication of BRPI0507048A publication Critical patent/BRPI0507048A/pt

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Abstract

USO DE BAIXA DOSAGEM DE ERITROPOETINA PARA ESTUMULAR CéLULAS PRECURSORAS ENDOTELIAIS, REGENERAR óRGãOS E RETIRAR A PROGRESSãO DE DANOS EM óRGãOS ALVO. A presente invenção refere-se ai uso de eritropoetina em baixa dosagem para estimular a mobilização fisiológica, proliferação e deferenciação de células precursoras endoteliais, para estimular a vasculogênese , para a terapia de doenças ligadas a uma disfunção de células precurdoras endoteliais, e para a preparação de composições farmacêuticas para o tratamento dessas doenças e de composições farmacêuticas que contêm eritropoetina e outras substâncias ativas apropriadas para estimular células precursoras endoteliais.
BRPI0507048-1A 2004-01-23 2005-01-22 uso de baixa dosagem de eritropoetina para estimular células precursoras endoteliais, regenerar órgãos e retardar a progressão de danos em órgão alvo BRPI0507048A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004004509A DE102004004509B4 (de) 2004-01-23 2004-01-23 Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden
PCT/EP2005/000618 WO2005070450A2 (de) 2004-01-23 2005-01-22 Verwendung von niedrig dosiertem erythropoietin zur behandlung von akuter oder chronischer niereninsuffizienz und zur behandlung von wunden

Publications (1)

Publication Number Publication Date
BRPI0507048A true BRPI0507048A (pt) 2007-06-12

Family

ID=34801204

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507048-1A BRPI0507048A (pt) 2004-01-23 2005-01-22 uso de baixa dosagem de eritropoetina para estimular células precursoras endoteliais, regenerar órgãos e retardar a progressão de danos em órgão alvo

Country Status (17)

Country Link
US (1) US20070161552A1 (pt)
EP (2) EP2156843A3 (pt)
JP (2) JP2007518769A (pt)
KR (1) KR20070007082A (pt)
CN (2) CN101601857A (pt)
AU (2) AU2005205917B2 (pt)
BR (1) BRPI0507048A (pt)
CA (1) CA2554234A1 (pt)
DE (2) DE102004004509B4 (pt)
EA (3) EA015350B1 (pt)
IL (2) IL177017A0 (pt)
NO (1) NO20063716L (pt)
NZ (1) NZ548697A (pt)
SG (1) SG149875A1 (pt)
UA (1) UA86400C2 (pt)
WO (1) WO2005070450A2 (pt)
ZA (1) ZA200606515B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
CN101460188B (zh) * 2006-06-07 2013-09-04 国立大学法人德岛大学 使用促红细胞生成素的局部缺血疾病的治疗
EP2018835B1 (de) 2007-07-09 2014-03-05 Augustinus Bader Wirkstoff abgebendes Pflaster
US20110123481A1 (en) * 2007-08-16 2011-05-26 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for therapeutic and cosmetic applications
JP5829400B2 (ja) * 2008-01-24 2015-12-09 レメドー バイオメッド リミテッド 骨再生のためのエリスロポイエチンおよびフィブロネクチン組成物
RU2491076C2 (ru) * 2008-03-31 2013-08-27 Аугустинус БАДЕР Способ и композиция для регенерации тканей с помощью стволовых или костномозговых клеток
WO2011108711A1 (ja) * 2010-03-04 2011-09-09 扶桑薬品工業株式会社 妊娠高血圧症候群モデル動物とその治療方法
RU2426174C1 (ru) * 2010-03-29 2011-08-10 Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" Способ фармакологической коррекции ишемии конечности, в том числе при l-name индуцированном дефиците оксида азота
WO2012003960A1 (en) 2010-07-06 2012-01-12 Augustinus Bader Topical application of erythropoietin for the treatment of eye disorders and injuries
WO2012031778A1 (de) 2010-09-12 2012-03-15 Augustinus Bader Verwendung von erythropoietin bei der heilung von wunden oder gewebedefekten ohne narbenbildung
WO2013057357A1 (es) * 2011-10-21 2013-04-25 Servicio Andaluz De Salud Método para la identificación de fármacos útiles para el tratamiento de enfermedades cardiovasculares
KR20150133222A (ko) * 2013-03-13 2015-11-27 스테메트릭스, 인코포레이티드. 피부 조성물 및 피부 조성물의 용도
KR20180093932A (ko) * 2015-12-16 2018-08-22 다이이찌 산쿄 가부시키가이샤 창상 치료제
JP7043784B2 (ja) * 2016-10-28 2022-03-30 大正製薬株式会社 発毛剤
CN108114282B (zh) * 2016-11-28 2021-03-02 北京大学第三医院 他汀类化合物治疗缺血性疾病的用途
CN106754650B (zh) * 2017-02-24 2018-10-02 哈尔滨中科赛恩斯生物技术有限公司 一种骨髓来源的内皮祖细胞培养方法
RU2720103C1 (ru) * 2019-10-16 2020-04-24 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Способ коррекции нарушений микроциркуляции в плаценте карбамилированным дарбэпоэтином при ADMA-подобной модели преэклампсии
KR102387136B1 (ko) 2020-04-06 2022-04-14 재단법인대구경북과학기술원 탈모의 예방 또는 치료용 펩티드 및 이의 이용
CN119080909A (zh) * 2024-08-29 2024-12-06 深圳赛保尔生物药业有限公司 负载peg-epo及间充质干细胞的组合物、药物及其制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5455790A (en) 1977-10-05 1979-05-04 Tomoyuki Tajima Production of erythropoetin
JPS6045849B2 (ja) 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin
US5198417A (en) * 1985-11-27 1993-03-30 Genetics Institute, Inc. Methods of treating pancytopenia and AIDS by co-administering EPO and colony stimulating factors
AU4072189A (en) * 1988-02-24 1989-09-22 American National Red Cross, The Device for site directed neovascularization and method for same
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
KR960701650A (ko) 1993-04-29 1996-03-28 찰스 엠. 브룩 에리트로포이에틴 유사체 조성물 및 방법(Eythropoietin analog compositions and methods)
IL110669A (en) 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
WO1998008537A1 (en) * 1996-08-27 1998-03-05 Hemosol Inc. Enhanced stimulation of erythropoiesis
US20020052309A1 (en) * 1996-09-11 2002-05-02 Athanasius A. Anagnostou Method of treating endothelial injury
US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
RU2144815C1 (ru) * 1996-12-24 2000-01-27 Общество с ограниченной ответственностью Научно-производственный центр "Сибирская природная косметика" Способ получения регенерирующего косметического крема для ухода за кожей
US6284260B1 (en) * 1998-02-04 2001-09-04 Veronica L. Zaharia Czeizler Treatment with erythropoietin of bleeding from benign and malignant lesions with normal and abnormal coagulation parameters
AR019025A1 (es) * 1998-04-09 2001-12-26 Roche Diagnostics Gmbh Uso de eritropoyetina en bajas dosis para producir un preparado farmaceutico para el tratamiento de hemocromatosis, preparado farmaceutico combinadoutilizado segun dicho uso y envase farmaceutico unitario que contiene al referido preparado farmaceutico combinado
EP0965349A1 (de) * 1998-06-18 1999-12-22 Roche Diagnostics GmbH Verwendung von Erythropoietin zur Behandlung von Hämochromatosen
US6284234B1 (en) * 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
TR200103785T2 (tr) * 1999-04-13 2002-06-21 The Kenneth S. Warren Institute, Inc. Uyarılabilir doku işlevinin periferik olarak uygulanan eritropoietin vasıtasıyla düzenlenmesi
US7078376B1 (en) * 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
JP2005503127A (ja) * 2001-04-04 2005-02-03 ジェンオディセ エリスロポエチン遺伝子の新規ポリヌクレオチド及びポリペプチド
US20030068297A1 (en) * 2001-08-18 2003-04-10 Deepak Jain Composition and methods for skin rejuvenation and repair
US6784154B2 (en) * 2001-11-01 2004-08-31 University Of Utah Research Foundation Method of use of erythropoietin to treat ischemic acute renal failure
US7335490B2 (en) * 2002-01-09 2008-02-26 Crucell Holland B.V. Use of erythropoietin for the preventive or curative treatment of cardiac failure
JP2005534650A (ja) * 2002-06-11 2005-11-17 ザ バーナム インスティテュート エリスロポイエチンおよびインスリン様増殖因子の神経保護的相乗作用
US20040009908A1 (en) * 2002-07-10 2004-01-15 Stamler Jonathan S. Methods for treating or preventing ischemic injury
DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
EP1673102A1 (en) * 2003-10-17 2006-06-28 Crucell Holland B.V. Treatment and prevention of decubitus
JP4947883B2 (ja) 2004-07-30 2012-06-06 キヤノン株式会社 通信装置、制御方法ならびにプログラム

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US20070161552A1 (en) 2007-07-12
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DE102004004509A1 (de) 2005-08-18
WO2005070450A8 (de) 2005-10-13
IL177017A0 (en) 2006-12-10
EA200702523A1 (ru) 2008-04-28
EP2156843A2 (de) 2010-02-24
ZA200606515B (en) 2008-01-08
KR20070007082A (ko) 2007-01-12
IL208497A0 (en) 2010-12-30
EA015350B1 (ru) 2011-06-30
JP2007518769A (ja) 2007-07-12
DE102004004509B4 (de) 2010-07-01
AU2005205917B2 (en) 2010-11-18
EP1711201A2 (de) 2006-10-18
EA200601359A1 (ru) 2006-12-29
CN101601857A (zh) 2009-12-16
UA86400C2 (ru) 2009-04-27
EA200900874A1 (ru) 2009-10-30
NO20063716L (no) 2006-10-18
JP2010235613A (ja) 2010-10-21
CN1942200A (zh) 2007-04-04
AU2010200621A1 (en) 2010-03-11
DE102004063927A1 (de) 2005-12-15
SG149875A1 (en) 2009-02-27
NZ548697A (en) 2011-01-28
EP2156843A3 (de) 2011-12-28
WO2005070450A2 (de) 2005-08-04

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