BRPI0508048A - derivados de pirrol como inibidores do fator xa - Google Patents

derivados de pirrol como inibidores do fator xa

Info

Publication number
BRPI0508048A
BRPI0508048A BRPI0508048-7A BRPI0508048A BRPI0508048A BR PI0508048 A BRPI0508048 A BR PI0508048A BR PI0508048 A BRPI0508048 A BR PI0508048A BR PI0508048 A BRPI0508048 A BR PI0508048A
Authority
BR
Brazil
Prior art keywords
factor
compounds
formulas
factor viia
inhibitors
Prior art date
Application number
BRPI0508048-7A
Other languages
English (en)
Inventor
Armin Bauer
Michael Wagner
Marc Nazare
Volkmar Wehner
Matthias Urmann
Hans Matter
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0508048A publication Critical patent/BRPI0508048A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE PIRROL COMO INIBIDORES DO FATOR Xa. A presente invenção refere-se à compostos das fórmulas (I) e (Ia), em que R¬0¬; R¬1¬; R¬2¬; R¬3¬; R¬4¬; R¬22¬, Q; V, G e M têm os significados indicados nas reivindicações. Os compostos das fórmulas I e Ia são compostos farmacologicamente ativos valiosos. Eles exibem um forte efeito anti-trombótico e são adequados para a terapia e profilaxia de distúrbios cardiovasculares tais como doenças trombo-embólicas ou restenoses. Eles são inibidores reversíveis das enzimas de coagulação sangüinea fator Xa (FXa) e/ou fator VIIa (FVIIa), e podem em geral ser aplicados em condições nas quais uma atividade indesejada de fator Xa e/ou fator VIIa está presente ou para a cura ou prevenção das quais uma inibição de fator Xa e/ou fator VIIa é pretendida. A invenção além disso refere-se à processos para a preparação de compostos das fórmulas (I) e (Ia), o emprego deles, em particular como ingredientes ativos em produtos farmacêuticos, e preparações farmacêuticas compreendendo-os.
BRPI0508048-7A 2004-02-27 2005-02-12 derivados de pirrol como inibidores do fator xa BRPI0508048A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04004503A EP1568698A1 (en) 2004-02-27 2004-02-27 Pyrrole-derivatives as factor Xa inhibitors
PCT/EP2005/001423 WO2005085239A2 (en) 2004-02-27 2005-02-12 PYRROLE-DERIVATIVES AS FACTOR Xa INHIBITORS

Publications (1)

Publication Number Publication Date
BRPI0508048A true BRPI0508048A (pt) 2007-07-17

Family

ID=34745922

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508048-7A BRPI0508048A (pt) 2004-02-27 2005-02-12 derivados de pirrol como inibidores do fator xa

Country Status (12)

Country Link
US (1) US7465806B2 (pt)
EP (2) EP1568698A1 (pt)
JP (1) JP4861306B2 (pt)
CN (1) CN1926137A (pt)
AU (1) AU2005219507A1 (pt)
BR (1) BRPI0508048A (pt)
CA (1) CA2557270A1 (pt)
IL (1) IL177253A0 (pt)
PE (1) PE20051170A1 (pt)
TW (1) TW200538110A (pt)
UY (1) UY28778A1 (pt)
WO (1) WO2005085239A2 (pt)

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EP1571154A1 (en) * 2004-03-03 2005-09-07 Aventis Pharma Deutschland GmbH Beta-aminoacid-derivatives as factor Xa inhibitors
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EP3613743B1 (en) 2008-01-04 2022-03-16 Intellikine, LLC Processes for the preparation of 1h-pyrazolo[3,4-d]pyrimidin-4-amine derivatives
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2435072A2 (en) 2009-05-27 2012-04-04 Yeda Research and Development Co. Ltd. Proteasome inhibitors and uses thereof
TWI674262B (zh) 2011-01-10 2019-10-11 美商英菲尼提製藥股份有限公司 製備異喹啉酮之方法及異喹啉酮之固體形式
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
EP2914296B2 (en) 2012-11-01 2021-09-29 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
IL239682B (en) 2013-01-08 2018-10-31 Kalvista Pharmaceuticals Ltd History of benzylamine and 2-(aminomethyl)pyridine
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WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
IL263235B (en) 2016-05-31 2022-07-01 Kalvista Pharmaceuticals Ltd History of pyrazoles as plasma kallikrein inhibitors
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
RU2754507C2 (ru) 2016-06-24 2021-09-02 Инфинити Фармасьютикалз, Инк. Комбинированная терапия
HUE057912T2 (hu) 2017-11-29 2022-06-28 Kalvista Pharmaceuticals Ltd Plazma kallikrein inhibitort tartalmazó dózisformák
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
WO2021028645A1 (en) 2019-08-09 2021-02-18 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
CN113192004B (zh) * 2021-04-01 2022-01-18 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） 一种基于冠脉多模影像裂纹形成和扩展的简化计算方法与斑块破裂风险量化的评估系统
WO2025024685A2 (en) * 2023-07-27 2025-01-30 Thomas Jefferson University Inhibitors of cib1 interactions and methods of use

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Also Published As

Publication number Publication date
EP1568698A1 (en) 2005-08-31
WO2005085239A3 (en) 2005-10-13
US7465806B2 (en) 2008-12-16
AU2005219507A1 (en) 2005-09-15
US20070049573A1 (en) 2007-03-01
CA2557270A1 (en) 2005-09-15
UY28778A1 (es) 2005-09-30
JP2007523927A (ja) 2007-08-23
JP4861306B2 (ja) 2012-01-25
KR20070000487A (ko) 2007-01-02
WO2005085239A2 (en) 2005-09-15
PE20051170A1 (es) 2006-02-07
CN1926137A (zh) 2007-03-07
TW200538110A (en) 2005-12-01
EP1725550A2 (en) 2006-11-29
IL177253A0 (en) 2006-12-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.