BRPI0508102A - inibidores de caspase e usos dos mesmos - Google Patents

inibidores de caspase e usos dos mesmos

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Publication number
BRPI0508102A
BRPI0508102A BRPI0508102-5A BRPI0508102A BRPI0508102A BR PI0508102 A BRPI0508102 A BR PI0508102A BR PI0508102 A BRPI0508102 A BR PI0508102A BR PI0508102 A BRPI0508102 A BR PI0508102A
Authority
BR
Brazil
Prior art keywords
caspase inhibitors
compounds
formula
present
provides
Prior art date
Application number
BRPI0508102-5A
Other languages
English (en)
Inventor
Jean-Damien Charrier
Steven Durrant
Michael Mortimore
Michael O'donnell
Alistair Rutherford
Sharn Ramaya
John R Studley
Martin Trudeau
Adam Looker
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34923260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0508102(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BRPI0508102A publication Critical patent/BRPI0508102A/pt

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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

INIBIDORES DE CASPASE E USOS DOS MESMOS. A presente invenção fornece um composto de fórmula(I): em que as variáveis são como aqui definidas. A presente invenção também fornece processos para preparar os compostos de fórmula (I), e intermediários dos mesmos, composições farmacêuticas compreendendo aqueles compostos, e métodos de uso dos compostos e composições.
BRPI0508102-5A 2004-02-27 2005-02-28 inibidores de caspase e usos dos mesmos BRPI0508102A (pt)

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US54861004P 2004-02-27 2004-02-27
US62974304P 2004-11-19 2004-11-19
US62966104P 2004-11-19 2004-11-19
PCT/US2005/006540 WO2005085236A2 (en) 2004-02-27 2005-02-28 Caspase inhibitors and uses thereof

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US9365612B2 (en) 2010-01-29 2016-06-14 United States Of America As Represented By The Secretary, Department Of Health And Human Services Caspase inhibitors
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KR20180101418A (ko) 2015-12-31 2018-09-12 코나터스 파마슈티칼스, 인크. 간 질환의 치료에서의 카스파제 억제제의 사용 방법
CN105853408B (zh) * 2016-04-15 2018-12-04 浙江大学 苯酰胺衍生物在制备Caspase-1抑制剂中的应用
MX2019003889A (es) 2016-10-05 2019-08-12 Novartis Ag Composiciones de combinacion que comprenden agonistas de fxr para tratar o prevenir una enfermedad o trastorno fibrotico o cirrotico.
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients
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US7652153B2 (en) 2010-01-26
NO20064351L (no) 2006-11-20
HK1159614A1 (en) 2012-08-03
KR20060129069A (ko) 2006-12-14
CA2557645C (en) 2013-09-24
US20050233979A1 (en) 2005-10-20
TW201217332A (en) 2012-05-01
AU2005219861A1 (en) 2005-09-15
TW200540152A (en) 2005-12-16
RU2382780C2 (ru) 2010-02-27
RU2006134258A (ru) 2008-04-10
HK1099757A1 (en) 2007-08-24
AU2005219861B2 (en) 2011-08-11
NO20064344L (no) 2006-10-19
US20100105914A1 (en) 2010-04-29
TWI362381B (en) 2012-04-21
JP2014140385A (ja) 2014-08-07
JP2011144203A (ja) 2011-07-28
EP2270004A1 (en) 2011-01-05
NZ549665A (en) 2010-09-30
EP1718639A2 (en) 2006-11-08
WO2005085236A3 (en) 2005-10-20
WO2005085236A2 (en) 2005-09-15
JP2007525503A (ja) 2007-09-06
CN102161656B (zh) 2013-02-20
CN102161656A (zh) 2011-08-24
CA2557645A1 (en) 2005-09-15
IL177709A0 (en) 2006-12-31

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