BRPI0508233A - derivados de isoquinolina e métodos para emprego destes - Google Patents

derivados de isoquinolina e métodos para emprego destes

Info

Publication number
BRPI0508233A
BRPI0508233A BRPI0508233-1A BRPI0508233A BRPI0508233A BR PI0508233 A BRPI0508233 A BR PI0508233A BR PI0508233 A BRPI0508233 A BR PI0508233A BR PI0508233 A BRPI0508233 A BR PI0508233A
Authority
BR
Brazil
Prior art keywords
methods
disease
isoquinoline
isoquinoline derivatives
effective amount
Prior art date
Application number
BRPI0508233-1A
Other languages
English (en)
Inventor
Prakash Jagtap
Erkan Baloglu
John Henry Van Duzer
Csaba Szabo
Andrew L Salzman
Aloka Roy
William Williams
Alexander Nivorozhkin
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of BRPI0508233A publication Critical patent/BRPI0508233A/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
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  • Biomedical Technology (AREA)
  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)

Abstract

DERIVADOS DE ISOQUINOLINA E MéTODOS PARA EMPREGO DESTES. A presente invenção refere-se a derivados de isoquinolina, composições compreendendo uma quantidade eficaz de um derivado de isoquinolina e métodos para tratar ou prevenir uma doença inflamatória, uma lesão de reperfusão, uma condição isquêmica, insuficiência renal, diabetes, uma complicação diabética, uma doença vascular, exceto uma doença cardiovascular, lesão de reoxigenação resultante de transplante de órgão, doença de Parkinson, ou câncer, compreedendo administrar a um animal em necessidade deste, uma quantidade eficaz de um derivado de isoquinolina.
BRPI0508233-1A 2004-02-26 2005-02-25 derivados de isoquinolina e métodos para emprego destes BRPI0508233A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54789904P 2004-02-26 2004-02-26
PCT/US2005/006243 WO2005082368A1 (en) 2004-02-26 2005-02-25 Isoquinoline derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0508233A true BRPI0508233A (pt) 2007-07-17

Family

ID=34910959

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508233-1A BRPI0508233A (pt) 2004-02-26 2005-02-25 derivados de isoquinolina e métodos para emprego destes

Country Status (14)

Country Link
US (1) US20050228007A1 (pt)
EP (2) EP2033645A1 (pt)
JP (1) JP2007527872A (pt)
KR (1) KR20060125909A (pt)
CN (1) CN1964716A (pt)
AU (1) AU2005216978A1 (pt)
BR (1) BRPI0508233A (pt)
CA (1) CA2557547A1 (pt)
EA (1) EA200601558A1 (pt)
IL (1) IL177650A0 (pt)
MX (1) MXPA06009701A (pt)
NO (1) NO20064328L (pt)
WO (1) WO2005082368A1 (pt)
ZA (1) ZA200607913B (pt)

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US6956035B2 (en) * 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
EP1603567A4 (en) * 2003-02-28 2006-10-18 Inotek Pharmaceuticals Corp TETRACYCLIC BENZAMIDE DERIVATIVES AND METHOD OF USE THEREOF
EP1722796A4 (en) * 2004-02-26 2008-01-23 Inotek Pharmaceuticals Corp TETRACYCLIC LACTAM DERIVATIVES AND USES THEREOF
CA2571001A1 (en) * 2004-06-16 2006-01-26 Inotek Pharmaceuticals Corporation Methods for treating or preventing erectile dysfunction or urinary incontinence
WO2006093677A1 (en) * 2005-02-25 2006-09-08 Inotek Pharmaceuticals Corporation Tetracyclic sulfonamide compounds and methods of use thereof
JP2008531562A (ja) 2005-02-25 2008-08-14 イノテック ファーマシューティカルズ コーポレイション 四環アミノ化合物および四環カルボキサミド化合物およびこれらの使用法
MX2007010335A (es) * 2005-02-25 2007-11-06 Inotek Pharmaceuticals Corp Compuestos de isoquinolina y metodos de uso de los mismos.
CN101316592A (zh) * 2005-08-24 2008-12-03 伊诺泰克制药公司 茚并异喹啉酮类似物及其用法
WO2007138355A1 (en) 2006-05-31 2007-12-06 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
JP4611444B2 (ja) 2007-01-10 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール
KR20090115879A (ko) * 2007-02-28 2009-11-09 이노텍 파마슈티컬스 코포레이션 인데노이소퀴놀리논 유사체와 이의 이용 방법
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2220073B1 (en) 2007-11-15 2014-09-03 MSD Italia S.r.l. Pyridazinone derivatives as parp inhibitors
GB0804755D0 (en) 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
JP2012511008A (ja) 2008-12-05 2012-05-17 持田製薬株式会社 ＩＸａ因子阻害薬としてのモルホリノン化合物
HK1201066A1 (en) * 2012-06-20 2015-08-21 霍夫曼-拉罗奇有限公司 Pyranopyridone inhibitors of tankyrase
ES2773710T3 (es) 2012-10-11 2020-07-14 Daiichi Sankyo Co Ltd Enlazadores para conjugados de anticuerpo - fármaco
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