BRPI0509359A - compostos de porfirina substituìda por piridila e métodos de empregos destes - Google Patents

compostos de porfirina substituìda por piridila e métodos de empregos destes

Info

Publication number
BRPI0509359A
BRPI0509359A BRPI0509359-7A BRPI0509359A BRPI0509359A BR PI0509359 A BRPI0509359 A BR PI0509359A BR PI0509359 A BRPI0509359 A BR PI0509359A BR PI0509359 A BRPI0509359 A BR PI0509359A
Authority
BR
Brazil
Prior art keywords
pyridyl
substituted porphyrin
methods
disease
cancer
Prior art date
Application number
BRPI0509359-7A
Other languages
English (en)
Inventor
William Williams
Garry Southan
Csaba Szabo
Original Assignee
Inotek Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inotek Pharmaceuticals Corp filed Critical Inotek Pharmaceuticals Corp
Publication of BRPI0509359A publication Critical patent/BRPI0509359A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)

Abstract

"COMPOSTOS DE PORFIRINA SUBSTITUìDA POR PIRIDILA E MéTODOS DE EMPREGO DESTES". A presente invenção refere-se aos compostos de Porfirina Substituídos por Piridila, composições compreendendo uma quantidade eficaz de um Composto de Porfirina Substituído por Piridila e métodos para tratamento ou prevenção de dano devido a exposição a uma espécie reativa, disfunção erétil devido a cirurgia, doença de pulmão, hiperoxia, doença neurode generativa, doença de fígado, dano do miocárdio durante cardioplegia, uma condição inflamatória, um dano de reperfusão, uma condição isquêmica, uma doença cardiovascular, diabetes, uma complicação diabética, câncer, um efeito colateral de quimioterapia de câncer, ou um dano induzido por radiação, ou para prolongar a meia-vida de um composto propenso a oxidação, compreendendo administrar a um indivíduo em necessidade deste uma quantidade eficaz de um Composto de Porfirina Substituíido por Piridila.
BRPI0509359-7A 2004-03-29 2005-03-25 compostos de porfirina substituìda por piridila e métodos de empregos destes BRPI0509359A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55755104P 2004-03-29 2004-03-29
US62846504P 2004-11-16 2004-11-16
PCT/US2005/010167 WO2005097123A2 (en) 2004-03-29 2005-03-25 Pyridyl-substituted porphyrin compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0509359A true BRPI0509359A (pt) 2007-09-04

Family

ID=35125604

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509359-7A BRPI0509359A (pt) 2004-03-29 2005-03-25 compostos de porfirina substituìda por piridila e métodos de empregos destes

Country Status (11)

Country Link
US (2) US7432369B2 (pt)
EP (1) EP1740094A4 (pt)
JP (1) JP2007530695A (pt)
KR (1) KR20060135922A (pt)
AU (1) AU2005231336A1 (pt)
BR (1) BRPI0509359A (pt)
CA (1) CA2561266A1 (pt)
EA (1) EA010834B1 (pt)
IL (1) IL178331A0 (pt)
MX (1) MXPA06011244A (pt)
WO (1) WO2005097123A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
KR20060135922A (ko) * 2004-03-29 2006-12-29 이노텍 파마슈티컬스 코포레이션 피리딜 치환된 포르피린 화합물 및 이의 사용 방법
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
JP2009510083A (ja) * 2005-09-28 2009-03-12 イノテック ファーマシューティカルズ コーポレイション Ｎ−ベンジル置換ピリジルポルフィリン化合物およびその使用方法
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
WO2008033444A2 (en) * 2006-09-11 2008-03-20 Eukarion, Inc. Anti-apoptotic benzodiazepine receptor ligand inhibitors
CA2665984C (en) 2006-10-12 2017-02-28 Activbiotics, Inc. Superoxide dismutase mimetics for the treatment of oral mucositis
KR20080047959A (ko) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 비만, 당뇨, 대사성 질환, 퇴행성 질환 및 미토콘드리아이상 질환의 치료 또는 예방을 위한 나프토퀴논계 약제조성물
CA2698552C (en) * 2007-08-28 2014-10-28 Technion Research And Development Foundation Ltd. Transition metal complexes of corroles for preventing cardiovascular diseases or disorders
KR101405823B1 (ko) * 2007-12-24 2014-06-12 주식회사 케이티앤지생명과학 녹내장의 치료 및 예방을 위한 약제 조성물
KR20090071829A (ko) * 2007-12-28 2009-07-02 주식회사 머젠스 신장질환의 치료 및 예방을 위한 약제 조성물
WO2009088860A2 (en) * 2007-12-31 2009-07-16 Inotek Pharmaceuticals Corporation A method of preventing contrast-induced nephropathy
JP5669123B2 (ja) * 2009-03-17 2015-02-12 国立大学法人 東京大学 発光によるビタミンｃ検出法及び定量法
CN102006871B (zh) * 2009-04-09 2013-05-22 松下电器产业株式会社 端粒酶反应的抑制方法
JP4510929B1 (ja) * 2009-04-09 2010-07-28 パナソニック株式会社 テロメラーゼ反応阻害方法およびそれに用いられるテロメラーゼ反応阻害剤
WO2012033916A1 (en) * 2010-09-08 2012-03-15 Southern Illinois University Edwardsville Method for treating chronic pain
CA2849456C (en) 2011-09-26 2021-12-07 Galera Therapeutics, Llc Methods for treatment of diseases
WO2014064697A1 (en) 2012-10-25 2014-05-01 Technion Research And Development Foundation Ltd. Method of treatment of disease
WO2015040622A1 (en) * 2013-09-22 2015-03-26 Laster Brenda The continuous long-term controlled release of telomerase inhibitors
US9034596B1 (en) 2014-04-17 2015-05-19 Kuwait University Method for fluorescent staining of cellular and intracellular membranes
HUE049926T2 (hu) 2015-08-11 2020-11-30 Galera Labs Llc Makrociklusos pentaazagyûrûkomplexek orális biológiai hozzáférhetõséggel
CN109414454A (zh) 2016-05-03 2019-03-01 加莱拉实验室有限责任公司 用于癌症治疗的组合疗法
EP3506907B1 (en) 2016-09-01 2023-06-07 Galera Labs, LLC Combination cancer therapy with a pentaaza macrocyclic ring complex and an ascorbate compound
CA3076008A1 (en) * 2017-09-29 2019-04-04 Duke University Fluoro substituted porphyrin compounds, pharmaceutical compositions comprising the same, and methods of preparing and using the same
EA201992431A1 (ru) 2017-10-13 2020-03-13 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса
IL276407B2 (en) * 2018-01-31 2025-01-01 Galera Labs Llc Combination cancer therapy with a pentase macrocyclic ring complex and a platinum-based anticancer agent
WO2024215973A1 (en) * 2023-04-13 2024-10-17 Biomimetix Jv, Llc Metalloporphyrins for reducing ischaemia-reperfusion injuries

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822899A (en) * 1985-04-12 1989-04-18 The University Of Michigan Metallic porphyrin complexes as catalysts in epoxidation reactions
US5990363A (en) * 1987-01-02 1999-11-23 Sun Company, Inc. Method for oxidizing alkanes using novel porphyrins synthesized from dipyrromethanes and aldehydes
US5227405A (en) * 1987-03-31 1993-07-13 Duke University Superoxide dismutase mimic
US5223538A (en) * 1987-03-31 1993-06-29 Duke University Superoxide dismutase mimic
JPH0338587A (ja) 1989-07-03 1991-02-19 Doujin Kagaku Kenkyusho:Kk 酸化反応を触媒する標識化合物
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US5747026A (en) 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
FR2717385B1 (fr) 1994-03-21 1996-04-19 Oreal Composition cosmétique contenant en association une superoxyde dismutase et une porphyrine.
US6245758B1 (en) * 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
WO1996009053A1 (en) * 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
US6013241A (en) * 1995-01-23 2000-01-11 Schering Aktiengesellschaft Use of porphyrin-complex or expanded porphyrin-complex compounds as an infarction localization diagnosticum
AU6031096A (en) 1995-06-05 1996-12-24 Duke University Nitrosylated and nitrated superoxide oxidants and reductants
JPH11509180A (ja) * 1995-06-07 1999-08-17 デューク・ユニバーシティ 酸化体脱除剤
US6002026A (en) * 1996-07-26 1999-12-14 The Trustees Of Princeton University Catalytic oxygenation of hydrocarbons by metalloporphyrin and metallosalen complexes
DE19647640A1 (de) 1996-11-18 1998-05-20 Basf Ag Monoverbrückte Porphyrin-Dimere und deren Metallkomplexe, Verfahren zu deren Herstellung sowie katalytische Verfahren unter Verwendung der Metallporphyrinkomplexe
CA2283057A1 (en) * 1997-02-05 1998-08-06 Board Of Regents, The University Of Texas System Porphyrin compounds as telomerase inhibitors
JP2001521939A (ja) * 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
US6194566B1 (en) * 1997-12-02 2001-02-27 Schering Aktiengesellschaft Process for the production of metalloporphyrin-metal complex conjugates
DE69928655T2 (de) 1998-04-24 2006-08-24 Duke University Substituierte porphyrine
IL126953A0 (en) * 1998-11-08 1999-09-22 Yeda Res & Dev Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives
EP1155019B1 (en) 1999-01-25 2005-12-07 National Jewish Medical and Research Center Substituted porphyrins and their therapeutic use
US6448239B1 (en) * 1999-06-03 2002-09-10 Trustees Of Princeton University Peroxynitrite decomposition catalysts and methods of use thereof
AU1087401A (en) * 1999-10-13 2001-04-23 Uab Research Foundation Metalloporphyrin treatment of neurologic disease
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
US6403788B1 (en) * 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
US6573258B2 (en) * 2000-09-27 2003-06-03 Frontier Scientific, Inc. Photodynamic porphyrin antimicrobial agents
JP2005508864A (ja) * 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
GB0114155D0 (en) 2001-06-11 2001-08-01 Unilever Plc Complex for catalytically bleaching a substrate
US20030086916A1 (en) * 2001-10-12 2003-05-08 Goligorsky Michael S. Use of peroxynitrite scavengers or peroxynitrite formation inhibitors that do not diminish nitric oxide synthesis or activity to reverse or prevent premature vascular senescence
FR2837202B1 (fr) 2002-03-15 2007-08-31 Centre Nat Rech Scient Nouveaux derives de porphyrines, leur procede de preparation compositions pharmaceutiques et utilisations
CN100420689C (zh) * 2002-04-08 2008-09-24 巩宪昌 带有大取代基的卟啉衍生物、其制备方法及其作为小分子抗氧化剂的应用
US6650137B2 (en) * 2002-04-11 2003-11-18 Daimlerchrysler Corporation Circuit for monitoring an open collector output circuit with a significant offset
EP1513537A4 (en) * 2002-06-07 2006-09-06 Univ Duke Substituted porphyrins
US7807825B2 (en) * 2004-02-09 2010-10-05 Duke University Substituted porphyrins
KR20060135922A (ko) * 2004-03-29 2006-12-29 이노텍 파마슈티컬스 코포레이션 피리딜 치환된 포르피린 화합물 및 이의 사용 방법
JP2009510083A (ja) * 2005-09-28 2009-03-12 イノテック ファーマシューティカルズ コーポレイション Ｎ−ベンジル置換ピリジルポルフィリン化合物およびその使用方法
BRPI0619261A2 (pt) 2005-11-30 2011-09-27 Inotek Pharmaceuticals Corp derivados de purina e métodos de uso desses

Also Published As

Publication number Publication date
WO2005097123A2 (en) 2005-10-20
WO2005097123A3 (en) 2005-12-22
IL178331A0 (en) 2007-02-11
EP1740094A2 (en) 2007-01-10
JP2007530695A (ja) 2007-11-01
US7432369B2 (en) 2008-10-07
US20080009473A1 (en) 2008-01-10
EA010834B1 (ru) 2008-12-30
MXPA06011244A (es) 2007-04-13
EA200601803A1 (ru) 2007-10-26
EP1740094A4 (en) 2008-09-03
AU2005231336A1 (en) 2005-10-20
KR20060135922A (ko) 2006-12-29
US20060003982A1 (en) 2006-01-05
CA2561266A1 (en) 2005-10-20

Similar Documents

Publication Publication Date Title
WO2005097123A3 (en) Pyridyl-substituted porphyrin compounds and methods of use thereof
EA200601558A1 (ru) Производные изохинолинов и способы их использования
WO2007038630A3 (en) N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof
BRPI0607240A2 (pt) derivados de maleimida, composições farmacêuticas e métodos para tratamento de cáncer
JP2009538897A5 (pt)
SMT201300096B (it) Inibitori di prolil idrossilasi
JP2008535902A5 (pt)
JP2008535903A5 (pt)
EA200600689A1 (ru) Замещённые бензазолы и их применение в качестве ингибиторов raf киназы
AR040673A1 (es) Inhibidores micobacterianos, composicion farmaceutica y proceso de preparacion del compuesto
ATE551060T1 (de) Zusammensetzungen und verfahren zur behandlung von neovaskulären erkrankungen
ECSP10010589A (es) Farmaco contra el cancer de higado
AR069244A1 (es) Metodos para administrar n-( 5- ter- butil- isoxixasol-3-il) -n'- (4(7-(2- morfolin-4-il- etoxi) imidazo (2,1-b) (1,3) benzotiazol -2-il) fenil) urea para tratar una enfermedad proliferante y composicion farmaceutica
IL182036A0 (en) Purine derivatives and methods of use thereof
NO20074737L (no) Isokinolinforbindelser og fremgangsmater for anvendelse derav
AR057295A1 (es) Combinaciones y procedimientos para usar un compuestos de indolinona
RU2011150250A (ru) Антагонисты пути hedgehog и их терапевтическое применение
WO2007046868A3 (en) Thiazolidine derivatives and their uses as therapeutic agents
AR048573A1 (es) Compuesto de 8-azoniabiciclo[3.2.1]octano sustituido en la posicion 3, composicion farmceutica que lo comprende y su uso para preparar esta ultima
MX2007003913A (es) Alquil-piridinas como inhibidores de 11 beta para diabetes.
JP2009510165A5 (pt)
BRPI0508052A (pt) derivados de lactamo tetracìclico e seus usos
BRPI0606191A2 (pt) compostos de amino e carboxamido tetracìclicos e métodos do seu uso
JP2018502100A5 (pt)
ATE419249T1 (de) Inhibitoren von mitotischem kinesin

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.