BRPI0509193B8 - método para diagnosticar doença cervical de alto grau em um paciente, e kit - Google Patents

método para diagnosticar doença cervical de alto grau em um paciente, e kit

Info

Publication number
BRPI0509193B8
BRPI0509193B8 BRPI0509193A BRPI0509193A BRPI0509193B8 BR PI0509193 B8 BRPI0509193 B8 BR PI0509193B8 BR PI0509193 A BRPI0509193 A BR PI0509193A BR PI0509193 A BRPI0509193 A BR PI0509193A BR PI0509193 B8 BRPI0509193 B8 BR PI0509193B8
Authority
BR
Brazil
Prior art keywords
biomarker
methods
cervical disease
cervical
patient
Prior art date
Application number
BRPI0509193A
Other languages
English (en)
Inventor
J Taylor Adriann
P Malinowski Douglas
R Parker Margaret
J Fischer Timothy
Original Assignee
Tripath Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tripath Imaging Inc filed Critical Tripath Imaging Inc
Publication of BRPI0509193A publication Critical patent/BRPI0509193A/pt
Publication of BRPI0509193B1 publication Critical patent/BRPI0509193B1/pt
Publication of BRPI0509193B8 publication Critical patent/BRPI0509193B8/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5755—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the uterine cervix, uterine corpus or endometrium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

métodos e composições para a detecção de doença cervical. a presente invenção refere-se a métodos e composições para identificar a doença cervical de alto grau em uma amostra do paciente. os métodos da invenção compreendem detectar a superexpressão de pelo menos um biomarcador em uma amostra de corpo, onde o biomarcador é seletivamente superexpresso na doença cervical de alto grau. nas reivindicações particulares, a amostra de corpo é um esfregaço cervical ou monocamada de células cervicais. os biomarcadores da invenção incluem genes e proteínas que estão envolvidos na regulação do ciclo celular, na transdução de sinal, e na replicação e na transcrição de dna. nas reivindicações particulares, o biomarcador é um gene de fase s. em alguns aspectos da invenção, a superexpressão de um biomarcador de interesse é detectada no nível de proteína usando anticorpos específicos para os biomarcadores ou no nível de ácido nucléico usando técnicas de hibridização de ácido nucléico. são adicionalmente proporcionados kits para efetuar os métodos da invenção.
BRPI0509193A 2004-03-24 2005-03-23 método para diagnosticar doença cervical de alto grau em um paciente, e kit BRPI0509193B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55649504P 2004-03-24 2004-03-24
US60/556.495 2004-03-24
PCT/US2005/009740 WO2005095964A2 (en) 2004-03-24 2005-03-23 Methods and compositions for the detection of cervical disease

Publications (3)

Publication Number Publication Date
BRPI0509193A BRPI0509193A (pt) 2007-08-28
BRPI0509193B1 BRPI0509193B1 (pt) 2019-03-26
BRPI0509193B8 true BRPI0509193B8 (pt) 2021-07-27

Family

ID=34964649

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509193A BRPI0509193B8 (pt) 2004-03-24 2005-03-23 método para diagnosticar doença cervical de alto grau em um paciente, e kit

Country Status (12)

Country Link
US (5) US7157233B2 (pt)
EP (2) EP1756577B1 (pt)
JP (2) JP4545189B2 (pt)
KR (3) KR20080075045A (pt)
CN (1) CN1957256B (pt)
AT (1) ATE549625T1 (pt)
AU (1) AU2005228026B2 (pt)
BR (1) BRPI0509193B8 (pt)
CA (1) CA2560782C (pt)
ES (1) ES2381644T3 (pt)
MX (1) MXPA06011020A (pt)
WO (1) WO2005095964A2 (pt)

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US7455973B2 (en) 2008-11-25
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CA2560782A1 (en) 2005-10-13
CN1957256B (zh) 2013-01-02
EP1756577A2 (en) 2007-02-28
ATE549625T1 (de) 2012-03-15
AU2005228026B2 (en) 2011-03-24
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US7510838B2 (en) 2009-03-31
US20070009885A1 (en) 2007-01-11
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BRPI0509193B1 (pt) 2019-03-26
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