ATE419249T1 - Inhibitoren von mitotischem kinesin - Google Patents

Inhibitoren von mitotischem kinesin

Info

Publication number: ATE419249T1
Authority: AT; Austria
Prior art keywords: compounds; inhibitors; mitotic kinesin; treating; ksp
Prior art date: 2004-04-06

Application number

AT05732607T

Other languages

English (en)

Inventor

Weibo Wang

Ryan Constantine

Liana Lagniton

Original Assignee

Novartis Vaccines & Diagnostic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-06

Filing date

2005-04-06

Publication date

2009-01-15

2005-04-06 Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE419249T1 publication Critical patent/ATE419249T1/de

Links

102000010638 Kinesin Human genes 0.000 title 1
108010063296 Kinesin Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000000394 mitotic effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT05732607T 2004-04-06 2005-04-06 Inhibitoren von mitotischem kinesin ATE419249T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56023504P	2004-04-06	2004-04-06

Publications (1)

Publication Number	Publication Date
ATE419249T1 true ATE419249T1 (de)	2009-01-15

Family

ID=34964986

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05732607T ATE419249T1 (de)	2004-04-06	2005-04-06	Inhibitoren von mitotischem kinesin

Country Status (15)

Country	Link
US (3)	US20080249112A1 (de)
EP (1)	EP1732926B1 (de)
JP (1)	JP4895220B2 (de)
KR (1)	KR20060135035A (de)
CN (1)	CN1984912A (de)
AT (1)	ATE419249T1 (de)
AU (1)	AU2005233576A1 (de)
BR (1)	BRPI0509653A (de)
CA (1)	CA2561904A1 (de)
DE (1)	DE602005012069D1 (de)
ES (1)	ES2318478T3 (de)
PL (1)	PL1732926T3 (de)
PT (1)	PT1732926E (de)
RU (1)	RU2006138864A (de)
WO (1)	WO2005100357A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ542227A (en) *	2003-03-07	2008-12-24	Astrazeneca Ab	Novel fused heterocycles and uses thereof
AR050920A1 (es) *	2003-03-07	2006-12-06	Astrazeneca Ab	Enantiomeros de heterociclos fusionados seleccionados y usos de los mismos
RU2006138864A (ru) *	2004-04-06	2008-05-20	Чирон Корпорейшн (Us)	Ингибиторы митотического кинезина
BRPI0510929A (pt) *	2004-06-18	2007-07-17	Chiron Corp	derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer
WO2006008523A1 (en) *	2004-07-22	2006-01-26	Astrazeneca Ab	Fused pyrimidones usefuel in the treatment and the prevention of cancer
EP1781674A1 (de)	2004-08-18	2007-05-09	AstraZeneca AB	Enantiomere von ausgewählten kondensierten pyrimidonen und anwendungen bei der behandlung und prävention von krebs
US20060041128A1 (en) *	2004-08-18	2006-02-23	Astrazeneca Ab	Selected fused heterocyclics and uses thereof
EP2091926B1 (de) *	2006-11-13	2015-10-21	Novartis AG	Substituierte pyrazol- und triazolverbindungen als ksp-inhibitoren
WO2008086122A2 (en) *	2007-01-05	2008-07-17	Novartis Ag	Imidazole derivatives as kinesin spindle protein inhibitors (eg-5)
WO2010042391A2 (en) *	2008-10-06	2010-04-15	Merck Sharp & Dohme Corp.	Hiv integrase inhibitors
WO2016020791A1 (en)	2014-08-05	2016-02-11	Novartis Ag	Ckit antibody drug conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2157285B (en)	1984-04-11	1987-10-28	Erba Farmitalia	1h, 7h-pyrazolo1, 5-a pyrimidine-7-one derivatives and process for their preparation
US20050107404A1 (en)	2001-12-06	2005-05-19	Fraley Mark E.	Mitotic kinesin inhibitors
RU2004135554A (ru) *	2002-05-09	2006-01-20	Цитокинетикс, Инк. (Us)	Пиримидиноны, композиции на их основе и способы их использования
EP1513820A4 (de)	2002-05-23	2006-09-13	Cytokinetics Inc	Verbindungen, zusammensetzungen und verfahren
EP1537089A4 (de)	2002-07-23	2008-04-16	Cytokinetics Inc	Verbindungen, zusammenstellungen und verfahren
WO2004064741A2 (en)	2003-01-17	2004-08-05	Cytokinetics Inc.	Compounds, compositions, and methods
US7345046B2 (en) *	2003-05-30	2008-03-18	Chiron Corporation	Heteroaryl-fused pyrimidinyl compounds as anticancer agents
CN1809563A (zh) *	2003-06-20	2006-07-26	希龙公司	吡啶并[1,2－a]嘧啶－4－酮化合物用作抗癌药
RU2006138864A (ru) *	2004-04-06	2008-05-20	Чирон Корпорейшн (Us)	Ингибиторы митотического кинезина

2005
- 2005-04-06 RU RU2006138864/04A patent/RU2006138864A/ru not_active Application Discontinuation
- 2005-04-06 CA CA002561904A patent/CA2561904A1/en not_active Abandoned
- 2005-04-06 KR KR1020067021822A patent/KR20060135035A/ko not_active Withdrawn
- 2005-04-06 CN CNA2005800174322A patent/CN1984912A/zh active Pending
- 2005-04-06 PL PL05732607T patent/PL1732926T3/pl unknown
- 2005-04-06 AT AT05732607T patent/ATE419249T1/de active
- 2005-04-06 DE DE602005012069T patent/DE602005012069D1/de not_active Expired - Lifetime
- 2005-04-06 US US11/547,834 patent/US20080249112A1/en not_active Abandoned
- 2005-04-06 BR BRPI0509653-7A patent/BRPI0509653A/pt not_active IP Right Cessation
- 2005-04-06 US US11/100,923 patent/US7504405B2/en not_active Expired - Fee Related
- 2005-04-06 AU AU2005233576A patent/AU2005233576A1/en not_active Abandoned
- 2005-04-06 PT PT05732607T patent/PT1732926E/pt unknown
- 2005-04-06 ES ES05732607T patent/ES2318478T3/es not_active Expired - Lifetime
- 2005-04-06 WO PCT/US2005/011642 patent/WO2005100357A1/en not_active Ceased
- 2005-04-06 EP EP05732607A patent/EP1732926B1/de not_active Expired - Lifetime
- 2005-04-06 JP JP2007507466A patent/JP4895220B2/ja not_active Expired - Fee Related
2009
- 2009-03-04 US US12/398,118 patent/US20090171082A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2007532554A (ja)	2007-11-15
US20090171082A1 (en)	2009-07-02
US7504405B2 (en)	2009-03-17
EP1732926B1 (de)	2008-12-31
CA2561904A1 (en)	2005-10-27
US20050228002A1 (en)	2005-10-13
CN1984912A (zh)	2007-06-20
WO2005100357A1 (en)	2005-10-27
EP1732926A1 (de)	2006-12-20
US20080249112A1 (en)	2008-10-09
DE602005012069D1 (de)	2009-02-12
PL1732926T3 (pl)	2009-06-30
AU2005233576A1 (en)	2005-10-27
KR20060135035A (ko)	2006-12-28
BRPI0509653A (pt)	2007-10-09
JP4895220B2 (ja)	2012-03-14
RU2006138864A (ru)	2008-05-20
PT1732926E (pt)	2009-04-03
ES2318478T3 (es)	2009-05-01

Legal Events

Date

Code

Title

Description

2009-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1732926

Country of ref document: EP

Publication	Publication Date	Title
ATE421512T1 (de)	2009-02-15	Inhibitoren von mitotischem kinesin
ATE446094T1 (de)	2009-11-15	Mitotische kinesin-hemmer
ATE424388T1 (de)	2009-03-15	Mitotische kinesinhemmer
ATE447577T1 (de)	2009-11-15	Mitotische kinesin-hemmer
DE60312516D1 (de)	2007-04-26	Inhibitoren von mitotischem kinesin
DE60222302D1 (de)	2007-10-18	Inhibitoren von mitotischem kinesin
ATE448207T1 (de)	2009-11-15	Mitotische kinesin-hemmer
TW200510380A (en)	2005-03-16	Mitotic kinesin inhibitors
WO2005017190A3 (en)	2005-12-15	Mitotic kinesin inhibitors
EA200870415A1 (ru)	2009-02-27	Хиназолины для ингибирования pdk 1
WO2005018547A3 (en)	2005-09-15	Mitotic kinesin inhibitors
WO2005060654A3 (en)	2005-12-08	Mitotic kinesin inhibitors
WO2005065183A3 (en)	2005-09-29	Mitotic kinesin inhibitors
WO2006068933A3 (en)	2006-12-07	Mitotic kinesin inhibitors
ATE419249T1 (de)	2009-01-15	Inhibitoren von mitotischem kinesin
NO20070589L (no)	2007-03-22	Mitotiske kinesin-inhibitorer.
ATE426605T1 (de)	2009-04-15	Inhibitoren von mitotischem kinesin
WO2006007496A3 (en)	2006-10-05	Mitotic kinesin inhibitors
WO2006007501A3 (en)	2006-07-27	Mitotic kinesin inhibitors
WO2006023440A3 (en)	2007-03-15	Mitotic kinesin inhibitors
WO2004087050A3 (en)	2005-03-24	Mitotic kinesin inhibitors
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