BRPI0509384A - processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo - Google Patents

processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo

Info

Publication number
BRPI0509384A
BRPI0509384A BRPI0509384-8A BRPI0509384A BRPI0509384A BR PI0509384 A BRPI0509384 A BR PI0509384A BR PI0509384 A BRPI0509384 A BR PI0509384A BR PI0509384 A BRPI0509384 A BR PI0509384A
Authority
BR
Brazil
Prior art keywords
salt
compound
preparation
hydrogenation process
asymmetric hydrogenation
Prior art date
Application number
BRPI0509384-8A
Other languages
English (en)
Inventor
David M Tellers
Guy R Humphrey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BRPI0509384A publication Critical patent/BRPI0509384A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)

Abstract

"PROCESSO DE HIDROGENAçãO ASSIMéTRICA PARA A PREPARAçãO DE UM COMPOSTO OU UM SAL DO MESMO, E, COMPOSTO OU UM SAL DO MESMO" A presente invenção fornece um processo de hidrogenação assimétrica para a preparação de antagonistas do receptor DP do cicloalcanoindol quiral de fórmula 1, em elevado excesso enantiomérico.
BRPI0509384-8A 2004-04-02 2005-03-29 processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo BRPI0509384A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55897204P 2004-04-02 2004-04-02
PCT/US2005/010501 WO2005097745A1 (en) 2004-04-02 2005-03-29 Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives

Publications (1)

Publication Number Publication Date
BRPI0509384A true BRPI0509384A (pt) 2007-09-18

Family

ID=34964828

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509384-8A BRPI0509384A (pt) 2004-04-02 2005-03-29 processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo

Country Status (19)

Country Link
US (1) US7576118B2 (pt)
EP (1) EP1737820B1 (pt)
JP (1) JP5239071B2 (pt)
CN (1) CN1942440B (pt)
AR (1) AR048459A1 (pt)
AT (1) ATE384046T1 (pt)
AU (1) AU2005230897B2 (pt)
BR (1) BRPI0509384A (pt)
CA (1) CA2561632A1 (pt)
CY (1) CY1107223T1 (pt)
DE (1) DE602005004393T2 (pt)
DK (1) DK1737820T3 (pt)
ES (1) ES2297695T3 (pt)
HR (1) HRP20080145T3 (pt)
PL (1) PL1737820T3 (pt)
PT (1) PT1737820E (pt)
SI (1) SI1737820T1 (pt)
TW (1) TWI344954B (pt)
WO (1) WO2005097745A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104311472B9 (zh) 2008-07-23 2020-03-17 艾尼纳制药公司 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物
PL2342205T4 (pl) 2008-08-27 2016-12-30 Podstawione tricykliczne pochodne kwasowe jako antagoniści receptora S1P1 użyteczni w leczeniu zaburzeń autoimmunologicznych i zapalnych
EP2528894A1 (en) * 2010-01-27 2012-12-05 Arena Pharmaceuticals, Inc. Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CN105503882B (zh) 2010-03-03 2019-07-05 艾尼纳制药公司 制备s1p1受体调节剂及其晶体形式的方法
CN102659664B (zh) * 2012-03-28 2015-01-21 中国计量学院 合成分离拉洛皮兰及其类似物的方法
CA3002540C (en) 2015-01-06 2023-11-07 Arena Pharmaceuticals, Inc. Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
JP6838744B2 (ja) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
KR20190113955A (ko) 2017-02-16 2019-10-08 아레나 파마슈티칼스, 인크. 장-외 증상을 갖는 염증성 장질환의 치료를 위한 화합물 및 방법
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
JP7397011B2 (ja) 2018-06-06 2023-12-12 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１ｐ１受容体に関連する状態を治療する方法
EP3847158B1 (en) 2018-09-06 2026-06-24 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3778857D1 (de) 1986-11-14 1992-06-11 Takasago Perfumery Co Ltd Katalytische produktion von optisch aktiven carbonsaeuren.
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
JP4769718B2 (ja) * 2003-08-07 2011-09-07 メルク シャープ エンド ドーム リミテッド アルツハイマー病及び関連症状の治療

Also Published As

Publication number Publication date
US7576118B2 (en) 2009-08-18
DE602005004393T2 (de) 2009-01-08
PL1737820T3 (pl) 2008-05-30
TWI344954B (en) 2011-07-11
JP2007532488A (ja) 2007-11-15
US20050222428A1 (en) 2005-10-06
CN1942440A (zh) 2007-04-04
JP5239071B2 (ja) 2013-07-17
EP1737820A1 (en) 2007-01-03
CA2561632A1 (en) 2005-10-20
ES2297695T3 (es) 2008-05-01
TW200606145A (en) 2006-02-16
AU2005230897B2 (en) 2011-03-03
SI1737820T1 (sl) 2008-04-30
HRP20080145T3 (en) 2008-04-30
CN1942440B (zh) 2011-09-14
WO2005097745A1 (en) 2005-10-20
AR048459A1 (es) 2006-04-26
CY1107223T1 (el) 2012-11-21
PT1737820E (pt) 2008-03-17
DK1737820T3 (da) 2008-04-28
ATE384046T1 (de) 2008-02-15
DE602005004393D1 (de) 2008-03-06
AU2005230897A1 (en) 2005-10-20
EP1737820B1 (en) 2008-01-16

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: ALTERADO DE: MERCK AND CO., INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: SCHERING CORPORATION, (US)

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B25G Requested change of headquarter approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.