BRPI0510150A - processo para preparação de derivados de 1,4-difenilacetidinonas - Google Patents
processo para preparação de derivados de 1,4-difenilacetidinonasInfo
- Publication number
- BRPI0510150A BRPI0510150A BRPI0510150-6A BRPI0510150A BRPI0510150A BR PI0510150 A BRPI0510150 A BR PI0510150A BR PI0510150 A BRPI0510150 A BR PI0510150A BR PI0510150 A BRPI0510150 A BR PI0510150A
- Authority
- BR
- Brazil
- Prior art keywords
- sym
- derivatives
- preparing
- alkyl
- coo
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000001768 cations Chemical class 0.000 abstract 3
- 150000001450 anions Chemical class 0.000 abstract 2
- 125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- -1 phosphonium ions Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCESSO PARA PREPARAçãO DE DERIVADOS DE 1,4-DIFENILACETIDINONAS. A presente invenção refere-se a um processo para preparação de derivados de 1,4 difenilazetidiononas, a partir de aminoamidas <225>substituídas de maneira apropriada na presença de agentes de sililação onde são empregados catalisadores de ciclização que apresentam como cátion(XII), íons fosfónio, e como ânion, aqueles de acordo com as seguintes fórmulas gerais (a) ou (b) ou (c) ou (d), sendo que os símbolos, substituintes e índices têm o seguinte significado: Z = C = O, C = S, S = O, SO~ 2~ ou C=NR¬ 20¬; K = O, S, NR¬ 21¬ ou CR¬ 22¬R¬ 23¬, L = NR¬ 24¬ ou CR¬ 25¬R¬ 26¬; n = 0 ou 1; M = O, C=O, NR¬ 27¬ ou CR¬ 28¬R¬ 29¬; Q = O, S, NR¬ 30¬, CR¬ 31¬R¬ 32¬, C=O, C=S, S=O, SO¬ 2¬ ou C=NR¬ 34¬ R=CR¬ 35¬ ou N; T = CR¬ 36¬ ou N; U = CR¬ 37¬ ou N; V = CR¬ 38¬ ou N; e os radicais indicados R¬ 16¬ até R¬ 19¬ por exemplo podem significar arila ou (C~ 1~-C~ 15~)alquila, aril(C~ 1~-C~ 10~)alquila e os radicais R¬ 20¬ até R¬ 32¬ e R¬ 34¬ até R¬ 38¬ e adicionalmente podem significar também H ou heteroarila; R¬ 39¬ e R¬ 40¬ por exemplo (C~ 1~-CF~ 6~)alquila. O ânion também pode ser R¬ 41¬O, R¬ 42¬COO<sym>, R¬ 42¬COO<sym> ou CI<sym> , Br<sym> ou I<sym> (combinado com Ag~ 2~O).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200410025071 DE102004025071B4 (de) | 2004-05-21 | 2004-05-21 | Verfahren zur Herstellung von Diphenylazetidinon-Derivaten |
| DE102005010770A DE102005010770A1 (de) | 2005-03-09 | 2005-03-09 | Verfahren zur Herstellung von 1,4-Diphenylazetidinon-Derivaten |
| PCT/EP2005/005498 WO2005113496A1 (de) | 2004-05-21 | 2005-05-20 | Verfahren zur herstellung von 1,4-diphenylazetidinon-derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0510150A true BRPI0510150A (pt) | 2007-10-02 |
Family
ID=37561403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0510150-6A BRPI0510150A (pt) | 2004-05-21 | 2005-05-20 | processo para preparação de derivados de 1,4-difenilacetidinonas |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7488818B2 (pt) |
| EP (1) | EP1756049B1 (pt) |
| JP (1) | JP2007538042A (pt) |
| KR (1) | KR20070027554A (pt) |
| AR (1) | AR049184A1 (pt) |
| AT (1) | ATE376997T1 (pt) |
| AU (1) | AU2005245124A1 (pt) |
| BR (1) | BRPI0510150A (pt) |
| CA (1) | CA2567149A1 (pt) |
| CY (1) | CY1107425T1 (pt) |
| DE (1) | DE502005001841D1 (pt) |
| DK (1) | DK1756049T3 (pt) |
| ES (1) | ES2294712T3 (pt) |
| HR (1) | HRP20070570T3 (pt) |
| IL (1) | IL178991A0 (pt) |
| MA (1) | MA28635B1 (pt) |
| MX (1) | MXPA06013456A (pt) |
| NZ (1) | NZ551413A (pt) |
| PL (1) | PL1756049T3 (pt) |
| PT (1) | PT1756049E (pt) |
| RS (1) | RS50539B (pt) |
| RU (1) | RU2380361C2 (pt) |
| TW (1) | TW200611896A (pt) |
| UY (1) | UY28912A1 (pt) |
| WO (1) | WO2005113496A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| WO2005062824A2 (en) * | 2003-12-23 | 2005-07-14 | Merck & Co., Inc. | Anti-hypercholesterolemic compounds |
| CA2550215A1 (en) | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
| UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| MY148538A (en) | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| US20090047716A1 (en) * | 2007-06-07 | 2009-02-19 | Nurit Perlman | Reduction processes for the preparation of ezetimibe |
| EP2414529A2 (en) | 2009-04-01 | 2012-02-08 | Matrix Laboratories Ltd | Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe |
| WO2011056895A1 (en) * | 2009-11-03 | 2011-05-12 | University Of Notre Dame Du Lac | Ionic liquids comprising heteraromatic anions |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9670237B2 (en) | 2011-09-22 | 2017-06-06 | Ut-Battelle, Llc | Phosphonium-based ionic liquids and their use in the capture of polluting gases |
| WO2015048765A1 (en) | 2013-09-30 | 2015-04-02 | University Of Notre Dame Du Lac | Compounds, complexes, compositions, methods and systems for heating and cooling |
| US10086331B2 (en) | 2013-11-05 | 2018-10-02 | University Of Notre Dame Du Lac | Carbon dioxide capture using phase change ionic liquids |
| JP6803138B2 (ja) * | 2014-10-22 | 2020-12-23 | 三星エスディアイ株式会社Samsung SDI Co., Ltd. | ホスホニウム系化合物、それを含むエポキシ樹脂組成物、およびそれを用いて製造された半導体装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW223059B (pt) * | 1991-07-23 | 1994-05-01 | Schering Corp | |
| AU681419B2 (en) * | 1993-07-09 | 1997-08-28 | Schering Corporation | Process for the synthesis of azetidinones |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| HUP0401081A3 (en) * | 2000-12-21 | 2010-06-28 | Sanofi Aventis Deutschland | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and their use |
| TWI291957B (en) * | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
-
2005
- 2005-05-20 CA CA002567149A patent/CA2567149A1/en not_active Abandoned
- 2005-05-20 ES ES05747892T patent/ES2294712T3/es not_active Expired - Lifetime
- 2005-05-20 DK DK05747892T patent/DK1756049T3/da active
- 2005-05-20 KR KR1020067024431A patent/KR20070027554A/ko not_active Withdrawn
- 2005-05-20 TW TW094116483A patent/TW200611896A/zh unknown
- 2005-05-20 HR HR20070570T patent/HRP20070570T3/xx unknown
- 2005-05-20 RU RU2006145444/04A patent/RU2380361C2/ru not_active IP Right Cessation
- 2005-05-20 PT PT05747892T patent/PT1756049E/pt unknown
- 2005-05-20 UY UY28912A patent/UY28912A1/es unknown
- 2005-05-20 AU AU2005245124A patent/AU2005245124A1/en not_active Abandoned
- 2005-05-20 RS RSP-2007/0483A patent/RS50539B/sr unknown
- 2005-05-20 PL PL05747892T patent/PL1756049T3/pl unknown
- 2005-05-20 AR ARP050102099A patent/AR049184A1/es not_active Application Discontinuation
- 2005-05-20 BR BRPI0510150-6A patent/BRPI0510150A/pt not_active IP Right Cessation
- 2005-05-20 EP EP05747892A patent/EP1756049B1/de not_active Expired - Lifetime
- 2005-05-20 NZ NZ551413A patent/NZ551413A/en unknown
- 2005-05-20 MX MXPA06013456A patent/MXPA06013456A/es active IP Right Grant
- 2005-05-20 DE DE502005001841T patent/DE502005001841D1/de not_active Expired - Lifetime
- 2005-05-20 AT AT05747892T patent/ATE376997T1/de not_active IP Right Cessation
- 2005-05-20 WO PCT/EP2005/005498 patent/WO2005113496A1/de not_active Ceased
- 2005-05-20 JP JP2007517094A patent/JP2007538042A/ja not_active Abandoned
-
2006
- 2006-11-01 IL IL178991A patent/IL178991A0/en unknown
- 2006-11-17 MA MA29462A patent/MA28635B1/fr unknown
- 2006-11-20 US US11/561,626 patent/US7488818B2/en not_active Expired - Fee Related
-
2008
- 2008-01-10 CY CY20081100037T patent/CY1107425T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL178991A0 (en) | 2007-03-08 |
| MA28635B1 (fr) | 2007-06-01 |
| ATE376997T1 (de) | 2007-11-15 |
| NZ551413A (en) | 2009-07-31 |
| HK1103296A1 (zh) | 2007-12-14 |
| EP1756049B1 (de) | 2007-10-31 |
| KR20070027554A (ko) | 2007-03-09 |
| MXPA06013456A (es) | 2007-03-01 |
| PT1756049E (pt) | 2007-12-17 |
| DE502005001841D1 (de) | 2007-12-13 |
| JP2007538042A (ja) | 2007-12-27 |
| CY1107425T1 (el) | 2013-03-13 |
| UY28912A1 (es) | 2005-12-30 |
| ES2294712T3 (es) | 2008-04-01 |
| PL1756049T3 (pl) | 2008-02-29 |
| AR049184A1 (es) | 2006-07-05 |
| RU2380361C2 (ru) | 2010-01-27 |
| DK1756049T3 (da) | 2008-02-25 |
| US7488818B2 (en) | 2009-02-10 |
| US20070149776A1 (en) | 2007-06-28 |
| RU2006145444A (ru) | 2008-06-27 |
| WO2005113496A1 (de) | 2005-12-01 |
| EP1756049A1 (de) | 2007-02-28 |
| CA2567149A1 (en) | 2005-12-01 |
| AU2005245124A1 (en) | 2005-12-01 |
| RS50539B (sr) | 2010-05-07 |
| HRP20070570T3 (en) | 2008-01-31 |
| TW200611896A (en) | 2006-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |