BRPI0511173A - 1-fenil-1,5-diidro-pirido-(3,2b)indol-2-onas substituìdas nas posições 6,7,8,9, de utilidade como agentes farmacêuticos antiinfecciosos - Google Patents
1-fenil-1,5-diidro-pirido-(3,2b)indol-2-onas substituìdas nas posições 6,7,8,9, de utilidade como agentes farmacêuticos antiinfecciososInfo
- Publication number
- BRPI0511173A BRPI0511173A BRPI0511173-0A BRPI0511173A BRPI0511173A BR PI0511173 A BRPI0511173 A BR PI0511173A BR PI0511173 A BRPI0511173 A BR PI0511173A BR PI0511173 A BRPI0511173 A BR PI0511173A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- methanimidamidyl
- indol
- pharmaceutical agents
- het
- Prior art date
Links
- 230000002924 anti-infective effect Effects 0.000 title abstract 2
- 150000005625 indol-2-ones Chemical class 0.000 title abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- -1 methanimidamidyl Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- ZNPKAOCQMDJBIK-UHFFFAOYSA-N nitrocyanamide Chemical group [O-][N+](=O)NC#N ZNPKAOCQMDJBIK-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1-FENIL-1,5-DIIDRO-PIRIDO-(3,2B)INDOL-2-ONAS SUBSTITUIDAS NAS POSIçõES 6,7,8,9, DE UTILIDADE COMO AGENTES FARMACêUTICOS ANTIINFECCIOSOS. A presente invenção refere-se aos compostos de fórmula (1): os N-oxidos, sais, formas estereoisoméricas, misturas racêmicas, pró-fármacos, ésteres e metabolitos dos mesmos, em que: X é NR¬ 2¬, O,S,SO,SO~ 2~; R¬ 1¬ é hidrogênio, ciano, halo, carbonila substituída, metanimidamidila, N-hidróxi-metanimidamidila, mono- ou di(C~ 1~-~ 4~alquil)metanimidamidila, Het~ 1~ ou Het~ 2~; n é l, 2 ou 3; R¬ 2¬ é hidrogênio, arila substituída por um radical -COOR¬ 4¬; ou R¬ 2¬ é ~ 1~-~ 10~alquila, C~ 2~-~ 10~alquenila ou C~ 3~-~ 7~cicloalquila substituídas; ou R¬ 2¬ é um radical de fórmula: C~ p~H~ 2p~CH(OR¬ 14¬)C~ q~H~ 2q~-R¬ 15¬ (b-3); -CH~ 2~-CH~ 2~-(O-CH~ 2~-CH~ 2~)~ m~-OR¬ 14¬ (b-4); CH~ 2~CH~ 2~-(O-CH~ 2~-CH~ 2~)~ m~-NR¬ 5a¬R¬ 5b¬ (b-5); -a¬ 1¬=a¬ 2¬-a¬ 3¬=a¬ 4¬- é -CH=CH-CH=CH-; -N=CH-CH=CH-; -CH=N-CH=CH-; -CH=CH-N=CH-; -CH=CH-CH=N- (c-5); em que um dos átomos de hidrogênio em (c-1) - (c-5) é substituído por particulares radicais; R¬ 3¬ é nitro, ciano, amina, halo, hidróxi, C~ 1~-~ 4~alquilóxi, hidroxicarbonila, carbonila substituída, metanimidamidila, mono-ou di(C~ 1~-~ 4~alquil)metanimidamidila, N-hidróxi-metanimidamidila ou Het~ 1~.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04102170 | 2004-05-17 | ||
| PCT/EP2005/052263 WO2005111035A1 (en) | 2004-05-17 | 2005-05-17 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511173A true BRPI0511173A (pt) | 2007-12-04 |
Family
ID=34929105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511173-0A BRPI0511173A (pt) | 2004-05-17 | 2005-05-17 | 1-fenil-1,5-diidro-pirido-(3,2b)indol-2-onas substituìdas nas posições 6,7,8,9, de utilidade como agentes farmacêuticos antiinfecciosos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7622581B2 (pt) |
| EP (1) | EP1751156B1 (pt) |
| JP (1) | JP2007538050A (pt) |
| CN (1) | CN1976930B (pt) |
| AR (1) | AR049637A1 (pt) |
| AT (1) | ATE481403T1 (pt) |
| BR (1) | BRPI0511173A (pt) |
| DE (1) | DE602005023600D1 (pt) |
| ES (1) | ES2351702T3 (pt) |
| MX (1) | MXPA06013313A (pt) |
| PL (1) | PL1751156T3 (pt) |
| RU (1) | RU2377243C2 (pt) |
| TW (1) | TW200607502A (pt) |
| WO (1) | WO2005111035A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2646090A1 (en) | 2006-04-03 | 2007-10-11 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 3,4-dihydro-imidazo[4,5-b]pyridin-5-ones |
| WO2008037783A1 (en) * | 2006-09-29 | 2008-04-03 | Tibotec Pharmaceuticals Ltd. | Process for preparing 2-oxo-2,5-dihydro-1h-pyrido[3,2-b]indole-3-carbonitriles |
| MX2011010582A (es) | 2009-04-09 | 2011-10-19 | Boehringer Ingelheim Int | Inhibidores de la replicacion del vih. |
| JP2013526496A (ja) * | 2010-05-14 | 2013-06-24 | アフェクティス ファーマシューティカルズ アーゲー | Ｐ２ｘ７ｒ拮抗剤の新規調製方法 |
| RU2451680C1 (ru) | 2011-02-21 | 2012-05-27 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Клатратный комплекс циклодекстрина или арабиногалактана с 9-фенил-симм-октагидроселеноксантеном, способ его получения (варианты), фармацевтическая композиция и лекарственное средство |
| RU2464042C1 (ru) * | 2011-03-31 | 2012-10-20 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | КЛАТРАТНЫЙ КОМПЛЕКС β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ(ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО |
| JP2014530177A (ja) | 2011-09-16 | 2014-11-17 | フオベア・フアルマシユテイカル | アニリン誘導体、それらの調製およびそれらの治療適用 |
| RU2640081C1 (ru) * | 2016-07-11 | 2017-12-26 | Общество с ограниченной ответственностью "ЛАЙФ САЙНСЕС ОХФК" | Фармацевтическая композиция и лекарственное средство на основе клатратного комплекса N-карбамоилметил-4-фенил-2-пирролидон или 4-фенилпирацетам с циклодекстрином, способы его получения (варианты) |
| EP3768882B1 (fr) * | 2018-03-20 | 2023-02-22 | Compagnie Generale Des Etablissements Michelin | Câblé textile aramide perfectionne à au moins triple torsion |
| CN108530381B (zh) * | 2018-05-07 | 2021-09-21 | 上海科技大学 | 一种由酰胺酯制备二胺衍生物的方法 |
| US20240208984A1 (en) * | 2021-03-31 | 2024-06-27 | Virginia Commonwealth University | Bivalent ligands to understand dimerization of the mu opioid receptor and the chemokine receptor ccr5 in neurological disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| SK283569B6 (sk) | 1993-10-01 | 2003-09-11 | Astra Aktiebolag | Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom |
| RU2140417C1 (ru) * | 1995-10-17 | 1999-10-27 | Институт физиологически активных веществ РАН | Производные гидрированных пиридо(4,3-b)индолов, способы их получения, фармацевтическая композиция и способ лечения |
| DK0904060T3 (da) | 1996-05-20 | 2004-04-13 | Janssen Pharmaceutica Nv | Antifungale præparater med forbedret biotilgængelighed |
| WO1998042318A1 (en) | 1997-03-26 | 1998-10-01 | Janssen Pharmaceutica N.V. | Pellets having a core coated with an antifungal and a polymer |
| WO2002059123A2 (en) * | 2000-12-18 | 2002-08-01 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
| AU2002246658A1 (en) * | 2000-12-18 | 2002-07-24 | Makarov, Vadim | Benzoylalkylindolepyridinium compounds and pharmaceutical compositions comprising such compounds |
| US6933303B2 (en) | 2001-10-19 | 2005-08-23 | Transtech Pharma, Inc. | Heteroaryl-fused nitrogen heterocycles as therapeutic agents |
| AP1927A (en) | 2002-11-15 | 2008-12-10 | Tibotec Pharm Ltd | Substituted indolepyridinium as anti-infective compounds |
-
2005
- 2005-05-17 WO PCT/EP2005/052263 patent/WO2005111035A1/en not_active Ceased
- 2005-05-17 US US11/568,840 patent/US7622581B2/en not_active Expired - Fee Related
- 2005-05-17 DE DE602005023600T patent/DE602005023600D1/de not_active Expired - Lifetime
- 2005-05-17 MX MXPA06013313A patent/MXPA06013313A/es active IP Right Grant
- 2005-05-17 RU RU2006144852/04A patent/RU2377243C2/ru not_active IP Right Cessation
- 2005-05-17 EP EP05747918A patent/EP1751156B1/en not_active Expired - Lifetime
- 2005-05-17 AT AT05747918T patent/ATE481403T1/de not_active IP Right Cessation
- 2005-05-17 PL PL05747918T patent/PL1751156T3/pl unknown
- 2005-05-17 AR ARP050102017A patent/AR049637A1/es not_active Application Discontinuation
- 2005-05-17 BR BRPI0511173-0A patent/BRPI0511173A/pt not_active IP Right Cessation
- 2005-05-17 JP JP2007517253A patent/JP2007538050A/ja active Pending
- 2005-05-17 CN CN2005800151994A patent/CN1976930B/zh not_active Expired - Fee Related
- 2005-05-17 ES ES05747918T patent/ES2351702T3/es not_active Expired - Lifetime
- 2005-05-17 TW TW094116034A patent/TW200607502A/zh unknown
-
2009
- 2009-10-09 US US12/576,761 patent/US20100029635A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE481403T1 (de) | 2010-10-15 |
| MXPA06013313A (es) | 2007-02-02 |
| JP2007538050A (ja) | 2007-12-27 |
| CN1976930A (zh) | 2007-06-06 |
| EP1751156B1 (en) | 2010-09-15 |
| US7622581B2 (en) | 2009-11-24 |
| US20100029635A1 (en) | 2010-02-04 |
| TW200607502A (en) | 2006-03-01 |
| RU2006144852A (ru) | 2008-06-27 |
| ES2351702T3 (es) | 2011-02-09 |
| RU2377243C2 (ru) | 2009-12-27 |
| AR049637A1 (es) | 2006-08-23 |
| WO2005111035A1 (en) | 2005-11-24 |
| EP1751156A1 (en) | 2007-02-14 |
| DE602005023600D1 (de) | 2010-10-28 |
| PL1751156T3 (pl) | 2011-03-31 |
| US20070167434A1 (en) | 2007-07-19 |
| CN1976930B (zh) | 2011-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013. |