BRPI0718966B8 - composto, composição farmacêutica, inibidor plk1 e agente antitumoral - Google Patents

composto, composição farmacêutica, inibidor plk1 e agente antitumoral

Info

Publication number
BRPI0718966B8
BRPI0718966B8 BRPI0718966A BRPI0718966A BRPI0718966B8 BR PI0718966 B8 BRPI0718966 B8 BR PI0718966B8 BR PI0718966 A BRPI0718966 A BR PI0718966A BR PI0718966 A BRPI0718966 A BR PI0718966A BR PI0718966 B8 BRPI0718966 B8 BR PI0718966B8
Authority
BR
Brazil
Prior art keywords
lower alkyl
group
alkyl group
compound
pharmaceutical composition
Prior art date
Application number
BRPI0718966A
Other languages
English (en)
Inventor
Kawamura Mikako
Mitsuya Morihiro
Hashihayata Takashi
Satoh Yoshiyuki
Original Assignee
Banyu Pharma Co Ltd
Msd Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd, Msd Kk filed Critical Banyu Pharma Co Ltd
Publication of BRPI0718966A2 publication Critical patent/BRPI0718966A2/pt
Publication of BRPI0718966B1 publication Critical patent/BRPI0718966B1/pt
Publication of BRPI0718966B8 publication Critical patent/BRPI0718966B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composto, composição farmacêutica, inibidor plki e agente antitumoral a presente invenção se refere a um composto representado pela fórmula [i]: ou um sal ou éster farmaceuticamente aceitável deste, onde r1 e r2, que podem ser os mesmos ou diferentes, são cada, um átomo de hidrogênio, um átomo de halogênio, um grupo alquila baixo que podem ser substituídos, ou um grupo ciclopropila; r3 e r4, que podem ser os mesmos ou diferentes, são cada, um átomo de hidrogênio, um grupo alquila baixo substituído por nr,rb, um grupo heterocíclico alifático com 4- a 6- membros, um grupo alquila baixo substituído por um grupo heterocíclico alifático com 4- a 6- membros, um grupo heterocíclico aromático com 5- a 6- membros, ou um grupo alquila baixo substituído por um grupo heterocíclico aromático com 5- a 6- membros; e r5 é um átomo de hidrogênio, a grupo ciano, um átomo de halogênio, ou um grupo alquila baixo.
BRPI0718966A 2006-12-28 2007-12-20 composto, composição farmacêutica, inibidor plk1 e agente antitumoral BRPI0718966B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2006-356575 2006-12-28
JP2006356575 2006-12-28
JP2007-265783 2007-10-11
JP2007265783 2007-10-11
PCT/JP2007/075224 WO2008081910A1 (en) 2006-12-28 2007-12-20 Novel aminopyrimidine derivatives as plk1 inhibitors

Publications (3)

Publication Number Publication Date
BRPI0718966A2 BRPI0718966A2 (pt) 2014-01-07
BRPI0718966B1 BRPI0718966B1 (pt) 2020-11-17
BRPI0718966B8 true BRPI0718966B8 (pt) 2021-05-25

Family

ID=39588592

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0718966A BRPI0718966B8 (pt) 2006-12-28 2007-12-20 composto, composição farmacêutica, inibidor plk1 e agente antitumoral

Country Status (24)

Country Link
US (1) US7977336B2 (pt)
EP (2) EP2116543A4 (pt)
JP (1) JPWO2008081914A1 (pt)
KR (1) KR101481388B1 (pt)
CN (1) CN101573361B (pt)
AR (1) AR064619A1 (pt)
AU (1) AU2007340530B2 (pt)
BR (1) BRPI0718966B8 (pt)
CA (1) CA2668738A1 (pt)
CL (1) CL2007003758A1 (pt)
CO (1) CO6190523A2 (pt)
CR (1) CR10784A (pt)
EC (1) ECSP099324A (pt)
GT (1) GT200900124A (pt)
IL (1) IL198675A0 (pt)
MA (1) MA31109B1 (pt)
MX (1) MX2009004920A (pt)
NO (1) NO20092770L (pt)
NZ (1) NZ577273A (pt)
PE (1) PE20081845A1 (pt)
RU (1) RU2458062C2 (pt)
SV (1) SV2009003258A (pt)
TW (1) TW200835485A (pt)
WO (2) WO2008081910A1 (pt)

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JP4489132B2 (ja) * 2008-08-22 2010-06-23 株式会社東芝 磁気記録媒体の製造方法
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
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PH12012500778A1 (en) 2009-10-30 2012-11-26 Janssen Pharmaceutica Nv IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
UY33213A (es) 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
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HK1206250A1 (en) 2012-06-26 2016-01-08 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and ped 10 inhibitors for use in the treatment of neurological or metabolic disorders
WO2014009305A1 (en) 2012-07-09 2014-01-16 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
WO2014028221A1 (en) 2012-07-31 2014-02-20 Crown Bioscience, Inc. Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug
WO2014046617A1 (en) * 2012-09-19 2014-03-27 Agency For Science, Technology And Research Compositions and methods for treating cancer
EP3194367B1 (en) 2014-09-17 2021-08-18 Boehringer Ingelheim International GmbH Tetrahydroisoquinoline derivatives and pharmaceutical compositions useful for the treatment of obesity and diabetes
WO2018191171A1 (en) * 2017-04-10 2018-10-18 City Of Hope P38 gamma inhibitors and method of use thereof
CN114269742B (zh) * 2019-07-10 2024-07-16 常州千红生化制药股份有限公司 作为治疗剂的4-(咪唑并[1,2-a]吡啶-3-基)-N-(吡啶基)嘧啶-2-胺的衍生物
EP4003992A1 (en) * 2019-07-24 2022-06-01 Merck Patent GmbH 4-(imidazo[1,2-a]pyridin-3-yl) -pyrimidine derivatives
CN112592318B (zh) * 2020-12-12 2022-05-03 贵州医科大学 2-(4-甲氨酰基)苯胺基-4-氨基嘧啶衍生物及应用
EP4597104A1 (en) 2022-09-29 2025-08-06 Japanese Foundation For Cancer Research Drug screening method based on drug discovery concept of cancer cell proliferation inhibition induced by disruption of chromosome regulation due to plk1 kinase activation
CN119318874B (zh) * 2024-12-18 2025-04-15 淄博凯美可工贸有限公司 一种节能型复合脱硫剂的制备方法

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Also Published As

Publication number Publication date
WO2008081910A1 (en) 2008-07-10
TW200835485A (en) 2008-09-01
KR101481388B1 (ko) 2015-01-12
CO6190523A2 (es) 2010-08-19
CA2668738A1 (en) 2008-07-10
EP2116543A4 (en) 2010-09-08
EP2114942A4 (en) 2010-09-08
MX2009004920A (es) 2009-05-21
RU2009128966A (ru) 2011-02-10
CL2007003758A1 (es) 2008-07-04
CN101573361B (zh) 2012-05-30
NO20092770L (no) 2009-09-25
EP2114942A1 (en) 2009-11-11
BRPI0718966A2 (pt) 2014-01-07
JPWO2008081914A1 (ja) 2010-04-30
ECSP099324A (es) 2009-06-30
PE20081845A1 (es) 2008-12-27
WO2008081914A1 (ja) 2008-07-10
KR20090092822A (ko) 2009-09-01
AR064619A1 (es) 2009-04-15
SV2009003258A (es) 2010-08-23
GT200900124A (es) 2010-11-03
AU2007340530B2 (en) 2012-09-13
MA31109B1 (fr) 2010-01-04
US20080305081A1 (en) 2008-12-11
CN101573361A (zh) 2009-11-04
CR10784A (es) 2009-09-16
EP2114942B1 (en) 2012-10-31
BRPI0718966B1 (pt) 2020-11-17
NZ577273A (en) 2011-03-31
EP2116543A1 (en) 2009-11-11
RU2458062C2 (ru) 2012-08-10
AU2007340530A1 (en) 2008-07-10
IL198675A0 (en) 2010-02-17
US7977336B2 (en) 2011-07-12

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Legal Events

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B25A Requested transfer of rights approved

Owner name: MSD K.K. (JP)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/12/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF