BRPI0511593A - formulações estáveis durante a transição do veìculo hidrofóbico para o meio hidrofìlico - Google Patents

formulações estáveis durante a transição do veìculo hidrofóbico para o meio hidrofìlico

Info

Publication number
BRPI0511593A
BRPI0511593A BRPI0511593-0A BRPI0511593A BRPI0511593A BR PI0511593 A BRPI0511593 A BR PI0511593A BR PI0511593 A BRPI0511593 A BR PI0511593A BR PI0511593 A BRPI0511593 A BR PI0511593A
Authority
BR
Brazil
Prior art keywords
transition
hydrophilic
dry particle
stable formulations
particle formulation
Prior art date
Application number
BRPI0511593-0A
Other languages
English (en)
Inventor
Gunjan Junnarkar
Michael A Desjardin
Kui Liu
Zengji Li
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35451371&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0511593(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0511593A publication Critical patent/BRPI0511593A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

FORMULAçõES ESTáVEIS DURANTE A TRANSIçãO DO VEìCULO HIDROFóBICO PARA O MEIO HIDROFìLICO. A presente invenção refere-se a uma formulação de suspensão para uso terapêutico que inclui um veículo hidrofóbico, não aquoso exibindo características de fluido viscoso, uma formulação de partícula seca compreendendo uma biomolécula dispersa no veículo e um tensoativo incorporado em pelo menos um dentre o veículo e a formulação de partícula seca. A formulação de partícula seca inclui uma interferona, um tampão, um tensoativo, e um ou mais establilizadores selecionados do grupo consistindo em um carboidrato, um antioxidante e um aminoácido.
BRPI0511593-0A 2004-05-25 2005-05-23 formulações estáveis durante a transição do veìculo hidrofóbico para o meio hidrofìlico BRPI0511593A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57466204P 2004-05-25 2004-05-25
US65022605P 2005-02-03 2005-02-03
PCT/US2005/017914 WO2005115333A2 (en) 2004-05-25 2005-05-23 A biomolecule-containing formulation of increased stability

Publications (1)

Publication Number Publication Date
BRPI0511593A true BRPI0511593A (pt) 2008-01-02

Family

ID=35451371

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511593-0A BRPI0511593A (pt) 2004-05-25 2005-05-23 formulações estáveis durante a transição do veìculo hidrofóbico para o meio hidrofìlico

Country Status (17)

Country Link
US (2) US20050266087A1 (pt)
EP (1) EP1755650B8 (pt)
JP (1) JP2008500345A (pt)
KR (1) KR20070046791A (pt)
AR (1) AR049118A1 (pt)
AT (1) ATE400291T1 (pt)
AU (1) AU2005247439B2 (pt)
BR (1) BRPI0511593A (pt)
CA (1) CA2568714A1 (pt)
DE (1) DE602005008053D1 (pt)
ES (1) ES2309768T3 (pt)
IL (1) IL179279A (pt)
MX (1) MXPA06013755A (pt)
NZ (1) NZ551258A (pt)
PE (1) PE20060456A1 (pt)
TW (1) TW200611712A (pt)
WO (1) WO2005115333A2 (pt)

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WO2005115333A2 (en) 2005-12-08
MXPA06013755A (es) 2007-02-08
DE602005008053D1 (de) 2008-08-21
ES2309768T3 (es) 2008-12-16
US20050266087A1 (en) 2005-12-01
US20080112994A1 (en) 2008-05-15
EP1755650A2 (en) 2007-02-28
IL179279A (en) 2010-06-30
KR20070046791A (ko) 2007-05-03
JP2008500345A (ja) 2008-01-10
WO2005115333A3 (en) 2006-05-18
EP1755650B1 (en) 2008-07-09
PE20060456A1 (es) 2006-06-02
AR049118A1 (es) 2006-06-28
EP1755650B8 (en) 2008-10-15
AU2005247439A1 (en) 2005-12-08
AU2005247439B2 (en) 2010-02-11
CA2568714A1 (en) 2005-12-08
TW200611712A (en) 2006-04-16
IL179279A0 (en) 2007-03-08
ATE400291T1 (de) 2008-07-15
NZ551258A (en) 2009-07-31

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