BRPI0615292A8 - composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada - Google Patents

composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada Download PDF

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Publication number
BRPI0615292A8
BRPI0615292A8 BRPI0615292A BRPI0615292A BRPI0615292A8 BR PI0615292 A8 BRPI0615292 A8 BR PI0615292A8 BR PI0615292 A BRPI0615292 A BR PI0615292A BR PI0615292 A BRPI0615292 A BR PI0615292A BR PI0615292 A8 BRPI0615292 A8 BR PI0615292A8
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BR
Brazil
Prior art keywords
compositions
methods
poorly soluble
increased stability
soluble water
Prior art date
Application number
BRPI0615292A
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English (en)
Inventor
Yang Andrew
P Desai Neil
M D Soon-Shiong Patrick
De Tapas
Yim Zachary
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Abraxis Bioscience Llc
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Publication date
Application filed by Abraxis Bioscience Llc filed Critical Abraxis Bioscience Llc
Publication of BRPI0615292A2 publication Critical patent/BRPI0615292A2/pt
Publication of BRPI0615292A8 publication Critical patent/BRPI0615292A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

método de estabilização de um agente farmacêutico, composição, métodos para sua preparação, frasco selado e kit compreendendo as ditas composições, bem como uso das mesmas. a presente invenção refere-se a composições farmacêuticas estáveis de agentes farmacêuticos de má solubilidade em água e agentes estabilizantes que funcionam para aumentar uma estabilidade das composições. o uso de agentes de estabilização fornece prolongada estabilidade de nanoparticula suspensões e outras formulações de agentes farmacêuticos pobremente solúveis em água tal como docetaxel sob certas condições, por exemplo, em diluição para administração.
BRPI0615292A 2005-08-31 2006-08-30 composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada BRPI0615292A8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US71286505P 2005-08-31 2005-08-31
US60/712,865 2005-08-31
US73696205P 2005-11-14 2005-11-14
US73693105P 2005-11-14 2005-11-14
US60/736,962 2005-11-14
US60/736,931 2005-11-14
PCT/US2006/034103 WO2007027941A2 (en) 2005-08-31 2006-08-30 Compositions and methods for preparation of poorly water soluble drugs with increased stability

Publications (2)

Publication Number Publication Date
BRPI0615292A2 BRPI0615292A2 (pt) 2011-05-17
BRPI0615292A8 true BRPI0615292A8 (pt) 2018-03-06

Family

ID=41404560

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0615292A BRPI0615292A8 (pt) 2005-08-31 2006-08-30 composições e métodos para preparação de fármacos de má solubilidade em água com estabilidade aumentada

Country Status (13)

Country Link
US (2) US8034765B2 (pt)
EP (2) EP3527202A1 (pt)
JP (1) JP5368093B2 (pt)
KR (2) KR101457834B1 (pt)
CN (1) CN101291658B (pt)
AU (1) AU2006284657B2 (pt)
BR (1) BRPI0615292A8 (pt)
CA (1) CA2620389C (pt)
ES (1) ES2719093T3 (pt)
IL (3) IL189600A (pt)
NO (3) NO343793B1 (pt)
NZ (2) NZ566705A (pt)
WO (1) WO2007027941A2 (pt)

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EP1928435B1 (en) 2019-01-09
CN101291658A (zh) 2008-10-22
NO344945B1 (no) 2020-07-27
US8034765B2 (en) 2011-10-11
NZ566705A (en) 2011-06-30
AU2006284657B2 (en) 2012-07-19
NO20200320A1 (no) 2008-05-28
US7981445B2 (en) 2011-07-19
JP5368093B2 (ja) 2013-12-18
WO2007027941A2 (en) 2007-03-08
WO2007027941A3 (en) 2007-04-26
IL189600A (en) 2016-09-29
EP3527202A1 (en) 2019-08-21
IL189600A0 (en) 2008-08-07
IL247486B (en) 2020-02-27
CA2620389A1 (en) 2007-03-08
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AU2006284657A1 (en) 2007-03-08
ES2719093T3 (es) 2019-07-08
EP1928435A2 (en) 2008-06-11
JP2009507027A (ja) 2009-02-19
NO20081576L (no) 2008-05-28
CA2620389C (en) 2014-06-17
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BRPI0615292A2 (pt) 2011-05-17
IL272236A (en) 2020-02-27
KR20130091790A (ko) 2013-08-19
US20090196933A1 (en) 2009-08-06
KR101643416B1 (ko) 2016-07-27
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NO343793B1 (no) 2019-06-11
KR101457834B1 (ko) 2014-11-05

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