BRPI0512482A - método de identificação de uma substáncia inibidora candidata e molécula antagonista - Google Patents

método de identificação de uma substáncia inibidora candidata e molécula antagonista

Info

Publication number
BRPI0512482A
BRPI0512482A BRPI0512482-4A BRPI0512482A BRPI0512482A BR PI0512482 A BRPI0512482 A BR PI0512482A BR PI0512482 A BRPI0512482 A BR PI0512482A BR PI0512482 A BRPI0512482 A BR PI0512482A
Authority
BR
Brazil
Prior art keywords
identifying
antagonist molecule
inhibitory substance
candidate inhibitory
hgf
Prior art date
Application number
BRPI0512482-4A
Other languages
English (en)
Inventor
Daniel K Kirchhofer
Paul M Moran
Mark D Peek
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BRPI0512482A publication Critical patent/BRPI0512482A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)

Abstract

MéTODO DE IDENTIFICAçãO DE UMA SUBSTáNCIA INIBIDORA CANDIDATA E MOLéCULA ANTAGONISTA A invenção fornece métodos e composições para a modulação da atividade da hepsina e a via de sinalização HGF/c-met em particular através da regulação da ativação de pró-HGF por hepsina
BRPI0512482-4A 2004-07-26 2005-07-25 método de identificação de uma substáncia inibidora candidata e molécula antagonista BRPI0512482A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59133904P 2004-07-26 2004-07-26
PCT/US2005/026446 WO2006014928A1 (en) 2004-07-26 2005-07-25 Methods and compositions for modulating hepatocyte growth factor activation

Publications (1)

Publication Number Publication Date
BRPI0512482A true BRPI0512482A (pt) 2008-03-11

Family

ID=35094502

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512482-4A BRPI0512482A (pt) 2004-07-26 2005-07-25 método de identificação de uma substáncia inibidora candidata e molécula antagonista

Country Status (15)

Country Link
US (3) US7432044B2 (pt)
EP (1) EP1774022B1 (pt)
JP (2) JP5226308B2 (pt)
KR (1) KR101222254B1 (pt)
CN (1) CN101023182B (pt)
AU (1) AU2005269463B2 (pt)
BR (1) BRPI0512482A (pt)
CA (1) CA2570323C (pt)
ES (1) ES2532610T3 (pt)
IL (1) IL179917A0 (pt)
MX (1) MX2007001064A (pt)
NZ (1) NZ551908A (pt)
RU (1) RU2405041C2 (pt)
WO (1) WO2006014928A1 (pt)
ZA (1) ZA200700745B (pt)

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DE60025342D1 (de) * 1999-04-09 2006-03-30 Us Gov Health & Human Serv Komplex aus n-glykolisierten proteinen (siblings) und faktor h
AU2005316169B2 (en) 2004-12-13 2011-11-17 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in the process of bone remodeling
US20100061996A1 (en) * 2006-06-22 2010-03-11 Genentech, Inc. Methods and compositions for modulating hepsin activation of urokinase-type plasminogen activator
CN101490088B (zh) 2006-06-22 2015-04-08 健泰科生物技术公司 用于靶向hepsin的方法和组合物
WO2008102452A1 (ja) * 2007-02-22 2008-08-28 Kringle Pharma Inc. Ｈｇｆ製剤
US20110206704A1 (en) * 2009-10-19 2011-08-25 Genentech, Inc. Methods and compositions for modulating hepatocyte growth factor activator
RU2539772C2 (ru) * 2009-10-22 2015-01-27 Дженентек, Инк. Способы и композиции для модуляции гепсином стимулирующего макрофаги белка
EP2491059B1 (en) 2009-10-22 2015-02-25 F.Hoffmann-La Roche Ag Anti-hepsin antibodies and methods using same
WO2011161189A1 (en) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anti-hepsin antibodies and methods of use
KR20120100027A (ko) 2011-03-02 2012-09-12 한국생명공학연구원 엔도사이토시스 모티프 및 단백질 도입 도메인을 포함하는 암 예방 또는 치료용 약학적 조성물
AU2012327227A1 (en) * 2011-11-07 2013-05-23 Isis Pharmaceuticals, Inc. Administration of Factor XI antisense oligonucleotides
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
KR102291913B1 (ko) 2014-04-28 2021-08-23 에자이 알앤드디 매니지먼트 가부시키가이샤 Ｈｇｆ의 동결건조 제제
US11130780B2 (en) 2015-03-09 2021-09-28 Washington University Inhibitors of growth factor activation enzymes
CN109072242A (zh) * 2016-02-23 2018-12-21 科罗拉多州立大学董事会法人团体 用于治疗神经损伤的基于肽的方法
AU2017232582B2 (en) 2016-03-17 2022-07-14 Eisai R&D Management Co., Ltd. Method for producing activated hepatocyte growth factor (HGF)
EP3919128A4 (en) * 2019-01-28 2023-01-11 Toray Industries, Inc. POLYETHYLENE GLYCOL MODIFIED BODY FOR HEPATORYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF

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Also Published As

Publication number Publication date
HK1100294A1 (en) 2007-09-14
US20090075317A1 (en) 2009-03-19
AU2005269463A1 (en) 2006-02-09
ES2532610T3 (es) 2015-03-30
EP1774022A1 (en) 2007-04-18
CN101023182A (zh) 2007-08-22
WO2006014928A1 (en) 2006-02-09
KR101222254B1 (ko) 2013-01-16
EP1774022B1 (en) 2014-12-31
IL179917A0 (en) 2007-05-15
CA2570323C (en) 2014-08-26
RU2007106862A (ru) 2008-09-10
RU2405041C2 (ru) 2010-11-27
US20100209956A1 (en) 2010-08-19
NZ551908A (en) 2009-10-30
JP2008507295A (ja) 2008-03-13
US20060084120A1 (en) 2006-04-20
JP2012196217A (ja) 2012-10-18
CN101023182B (zh) 2013-04-17
CA2570323A1 (en) 2006-02-09
KR20070037499A (ko) 2007-04-04
JP5226308B2 (ja) 2013-07-03
MX2007001064A (es) 2007-04-12
US7432044B2 (en) 2008-10-07
AU2005269463B2 (en) 2011-08-18
ZA200700745B (en) 2008-07-30

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2472 DE 22-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.