BRPI0512661B8 - derivado de arilamidina ou um sal do mesmo, composto ou um sal do mesmo, e, composto antifúngico - Google Patents

derivado de arilamidina ou um sal do mesmo, composto ou um sal do mesmo, e, composto antifúngico

Info

Publication number
BRPI0512661B8
BRPI0512661B8 BRPI0512661A BRPI0512661A BRPI0512661B8 BR PI0512661 B8 BRPI0512661 B8 BR PI0512661B8 BR PI0512661 A BRPI0512661 A BR PI0512661A BR PI0512661 A BRPI0512661 A BR PI0512661A BR PI0512661 B8 BRPI0512661 B8 BR PI0512661B8
Authority
BR
Brazil
Prior art keywords
salt
compound
derivative
arylamidine
antifungal
Prior art date
Application number
BRPI0512661A
Other languages
English (en)
Inventor
Kunitani Kazuto
Hayashi Kazuya
Uehara Sayuri
Morita Teiichi
Original Assignee
Fujifilm Toyama Chemical Co Ltd
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Toyama Chemical Co Ltd, Toyama Chemical Co Ltd filed Critical Fujifilm Toyama Chemical Co Ltd
Publication of BRPI0512661A publication Critical patent/BRPI0512661A/pt
Publication of BRPI0512661B1 publication Critical patent/BRPI0512661B1/pt
Publication of BRPI0512661B8 publication Critical patent/BRPI0512661B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

derivado de arilamidina ou um sal do mesmo, composto ou um sal do mesmo, e, composto antifúngico um derivado de arilamidina representado pela fórmula geral (em que r1 representa amidino opcionalmente protegido ou substituído; e r2 e r3 são os mesmos ou diferentes e cada um representa hidrogênio ou halogênio) ou um sal do derivado. o derivado e o sal têm atividade potente contra fungos incluindo alguns tendo tolerância aos medicamentos tipo azol e ainda têm segurança alta e propriedades excelentes em um teste de toxicidade de dose repetido. eles são consequentemente úteis como um composto antifúngico excelente.
BRPI0512661A 2004-06-30 2005-06-28 derivado de arilamidina ou um sal do mesmo, composto ou um sal do mesmo, e, composto antifúngico BRPI0512661B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004-193386 2004-06-30
JP2004193386 2004-06-30
PCT/JP2005/011809 WO2006003881A1 (ja) 2004-06-30 2005-06-28 新規なアリールアミジン誘導体およびその塩ならびにそれらを含有する抗真菌剤

Publications (3)

Publication Number Publication Date
BRPI0512661A BRPI0512661A (pt) 2008-04-01
BRPI0512661B1 BRPI0512661B1 (pt) 2020-10-27
BRPI0512661B8 true BRPI0512661B8 (pt) 2021-05-25

Family

ID=35782688

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512661A BRPI0512661B8 (pt) 2004-06-30 2005-06-28 derivado de arilamidina ou um sal do mesmo, composto ou um sal do mesmo, e, composto antifúngico

Country Status (20)

Country Link
US (1) US7700623B2 (pt)
EP (1) EP1767526B1 (pt)
JP (1) JP4885722B2 (pt)
KR (1) KR101169694B1 (pt)
CN (1) CN100567267C (pt)
AU (1) AU2005258613B2 (pt)
BR (1) BRPI0512661B8 (pt)
CA (1) CA2572161C (pt)
CY (1) CY1113266T1 (pt)
DK (1) DK1767526T3 (pt)
ES (1) ES2393924T3 (pt)
IL (1) IL180192A (pt)
NO (1) NO339158B1 (pt)
NZ (1) NZ552184A (pt)
PL (1) PL1767526T3 (pt)
PT (1) PT1767526E (pt)
RU (1) RU2359959C2 (pt)
SI (1) SI1767526T1 (pt)
WO (1) WO2006003881A1 (pt)
ZA (1) ZA200700806B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0607910A2 (pt) * 2005-04-07 2010-03-23 Toyama Chemical Co Ltd composiÇço farmacÊutica para tratar infecÇÕes féngicas, e, mÉtodo de uso de um derivado de arilamidina ou um sal do mesmo
NZ564759A (en) * 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
CN101351204B (zh) * 2005-12-29 2011-01-12 富山化学工业株式会社 芳脒衍生物及其盐、以及含有它们的抗真菌药
MX2009003533A (es) * 2006-10-06 2009-07-17 Toyama Chemical Co Ltd Composición farmacéutica que comprende derivado de fenilamidina y método para usar la composición farmacéutica en combinación con el aceite antifúngico.
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
TWI395735B (zh) * 2007-07-04 2013-05-11 Toyama Chemical Co Ltd ４－｛３－〔４－（３－｛４－〔胺基（丁氧基羰基亞胺基）甲基〕苯氧基｝丙基）－１－哌啶基〕丙氧基｝－ｎ’－（丁氧基羰基）苄脒之新穎結晶
DE102008007381A1 (de) 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten
US9662308B2 (en) 2008-02-01 2017-05-30 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Orally bioavailable pentamidine prodrugs for the treatment of diseases
AU2014200451B2 (en) * 2008-02-01 2016-03-03 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg Use of amidoxime carboxylic acid esters and n-hydroxyguanidine carboxylic acid esters for producing prodrugs
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
WO2011104540A1 (en) * 2010-02-24 2011-09-01 Generics [Uk] Limited One step process for the preparation of capecitabine
TWI544924B (zh) 2010-09-30 2016-08-11 富山化學工業股份有限公司 經皮吸收製劑
US20130288956A1 (en) 2010-11-05 2013-10-31 Eisai R&D Management Co., Ltd. Combined pharmaceutical composition as antifungal agent
CA3155443A1 (en) * 2019-11-04 2021-05-14 Thomas F. PATTERSON Composition and method for treating candida auris infection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1150162C (zh) * 1997-11-20 2004-05-19 帝人株式会社 联苯基脒衍生物
NZ534962A (en) * 2002-03-06 2005-07-29 Toyama Chemical Co Ltd Novel arylamidine derivative or salt thereof

Also Published As

Publication number Publication date
BRPI0512661B1 (pt) 2020-10-27
KR101169694B1 (ko) 2012-07-31
ZA200700806B (en) 2008-12-31
DK1767526T3 (da) 2012-11-12
KR20070030305A (ko) 2007-03-15
EP1767526A4 (en) 2009-05-06
JPWO2006003881A1 (ja) 2008-04-17
CN100567267C (zh) 2009-12-09
NO339158B1 (no) 2016-11-14
IL180192A (en) 2011-01-31
EP1767526A1 (en) 2007-03-28
WO2006003881A1 (ja) 2006-01-12
JP4885722B2 (ja) 2012-02-29
AU2005258613B2 (en) 2011-03-17
EP1767526B1 (en) 2012-10-24
US7700623B2 (en) 2010-04-20
SI1767526T1 (sl) 2013-02-28
CA2572161A1 (en) 2006-01-12
PL1767526T3 (pl) 2013-03-29
ES2393924T3 (es) 2013-01-02
IL180192A0 (en) 2007-06-03
RU2359959C2 (ru) 2009-06-27
AU2005258613A1 (en) 2006-01-12
PT1767526E (pt) 2012-12-10
RU2007103176A (ru) 2008-08-10
CY1113266T1 (el) 2016-04-13
US20080319016A1 (en) 2008-12-25
NO20070455L (no) 2007-01-24
CN1976901A (zh) 2007-06-06
NZ552184A (en) 2009-11-27
BRPI0512661A (pt) 2008-04-01
CA2572161C (en) 2012-10-02

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: FUJIFILM TOYAMA CHEMICAL CO., LTD. (JP)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 27/10/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/06/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF