BRPI0512865A - método para aumentar a suscetibilidade de inibidores da deformilase de peptìdio usando inibidores de bomba de efluxo - Google Patents

método para aumentar a suscetibilidade de inibidores da deformilase de peptìdio usando inibidores de bomba de efluxo

Info

Publication number
BRPI0512865A
BRPI0512865A BRPI0512865-0A BRPI0512865A BRPI0512865A BR PI0512865 A BRPI0512865 A BR PI0512865A BR PI0512865 A BRPI0512865 A BR PI0512865A BR PI0512865 A BRPI0512865 A BR PI0512865A
Authority
BR
Brazil
Prior art keywords
inhibitors
efflux pump
peptide deformylase
increasing susceptibility
increasing
Prior art date
Application number
BRPI0512865-0A
Other languages
English (en)
Inventor
Charles Richard Dean
Neil Stewart Ryder
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0512865A publication Critical patent/BRPI0512865A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

MéTODO PARA AUMENTAR A SUSCETIBILIDADE DE INIBIDORES DA DEFORMILASE DE PEPTìDIO USANDO INIBIDORES DE BOMBA DE EFLUXO. A presente invenção fornece métodos e composições para aumentar a suscetibilidade de inibidores da PDF contra organismos Gram negativos usando inibidores da bomba de efluxo.
BRPI0512865-0A 2004-06-30 2005-06-29 método para aumentar a suscetibilidade de inibidores da deformilase de peptìdio usando inibidores de bomba de efluxo BRPI0512865A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58402304P 2004-06-30 2004-06-30
PCT/EP2005/007008 WO2006002896A1 (en) 2004-06-30 2005-06-29 Method for increasing the susceptibility of peptide deformylase inhibitors by using efflux pump inhibitors

Publications (1)

Publication Number Publication Date
BRPI0512865A true BRPI0512865A (pt) 2008-04-08

Family

ID=35149202

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512865-0A BRPI0512865A (pt) 2004-06-30 2005-06-29 método para aumentar a suscetibilidade de inibidores da deformilase de peptìdio usando inibidores de bomba de efluxo

Country Status (12)

Country Link
US (1) US20090156645A1 (pt)
EP (1) EP1763348A1 (pt)
JP (1) JP2008505145A (pt)
KR (1) KR20070030244A (pt)
CN (1) CN1976703A (pt)
AU (1) AU2005259488B2 (pt)
BR (1) BRPI0512865A (pt)
CA (1) CA2569681A1 (pt)
MX (1) MXPA06015106A (pt)
RU (1) RU2007103299A (pt)
TW (1) TW200607492A (pt)
WO (1) WO2006002896A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW465235B (en) 1998-09-17 2001-11-21 United Video Properties Inc Electronic program guide with digital storage
WO2007041156A2 (en) 2005-09-29 2007-04-12 Nektar Therapeutics Antibiotic formulations, unit doses, kits, and methods
CA2940237C (en) 2014-02-21 2023-03-07 Frost Biologic, Inc. Antimitotic amides for the treatment of cancer and proliferative disorders
JP6678599B2 (ja) * 2014-06-13 2020-04-08 ユニバーシティー オブ ロチェスター 小分子排出ポンプ阻害剤
CN111658646B (zh) * 2020-06-28 2021-03-02 河南工业大学 2,6-双(2-苯并咪唑基)吡啶在制备耐碳青霉烯类铜绿假单胞菌感染药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114310A (en) * 1998-01-23 2000-09-05 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
ATE222115T1 (de) * 1998-05-18 2002-08-15 Upjohn Co Verbesserung der antibakteriellen wirkung von oxazolidinon durch arginin derivate
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
US7829543B2 (en) * 2003-01-07 2010-11-09 Paratek Pharmaceuticals, Inc. Substituted polyamines as inhibitors of bacterial efflux pumps

Also Published As

Publication number Publication date
WO2006002896A1 (en) 2006-01-12
TW200607492A (en) 2006-03-01
EP1763348A1 (en) 2007-03-21
AU2005259488B2 (en) 2009-10-01
MXPA06015106A (es) 2007-02-08
KR20070030244A (ko) 2007-03-15
CN1976703A (zh) 2007-06-06
CA2569681A1 (en) 2006-12-06
RU2007103299A (ru) 2008-08-10
JP2008505145A (ja) 2008-02-21
US20090156645A1 (en) 2009-06-18
AU2005259488A1 (en) 2006-01-12

Similar Documents

Publication Publication Date Title
EP3785120A4 (en) FAST AND OPTIMIZED RECOVERY USING DELTA INFORMATION
HUS1900004I1 (hu) Transztiretin-expresszió gátlására szolgáló készítmények és eljárások
FR2883179B1 (fr) Comprime enrobe
EA201001860A1 (ru) Ингибиторы дпп-4 для лечения неалкогольной жировой дистрофии печени
BRPI0908951A2 (pt) compostos de minociclina e método de uso dos mesmos
PT1931350E (pt) Administração de inibidores de dipeptidil peptidase
CR10068A (es) Anticuerpos anti mn y métodos para su utilización
EP2035014A4 (en) FUCOIDAN COMPOSITIONS AND METHOD
CR10730A (es) Anticuerpos agonistas anti notch3 y su uso en el tratamiento de las enfermedades relacionadas con el gen notch3
MX2014000518A (es) Inhibidores de la tirosina quinasa de bruton.
BR112014014558A2 (pt) composição farmacêutica, uso de um antagonista de crth2 e de um inibidor de bomba de prótons, e, kit para o tratamento de esofagite eosinofílica
MA31874B1 (fr) Inhibiteurs de bêta-lactamases
EA200870029A1 (ru) Способ применения антагонистов il-6 с ингибиторами протеасом
ECSP077238A (es) Composiciones para entrega de drogas altamente solubles en agua
BR112012008385A2 (pt) inibidores de p13 cinase e uso dos mesmos.
HN2005000768A (es) Proceso
CL2009000178A1 (es) Composicion que comprende un anticuerpo contra el dominio ii de her2, sus variantes acidas, secuencias que comprenden las cadenas livianas y pesadas de este; formulacion farmaceutica que comprende dicho anticuerpo y uso de este para cancer her2 positivo.
EA200971051A1 (ru) Ингибиторы p70 s6 киназы
DK2302055T3 (da) Fremgangsmåder og sammensætninger involverende miRNA og miRNA-inhibitormolekyler
BRPI0513897A (pt) diferenciação de células-tronco
ECSP13012673A (es) Métodos y composiciones para inmunoterapia para enfermedad neural
DE102007013391A8 (de) Zeitinformationsquelle
AR059096A1 (es) Anticuerpos anti- efrina -b2 y metodos que usan estos
DK3461871T3 (da) Sammensætninger omfattende trans hfc-1234ze og hfc-1234yf
DK1704859T3 (da) Kontrol af androgen receptor-afhængig genenkspression ved inhibering af amin-oxidase-aktiviteten af lysin-specifik demetylase (LSD1)

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.