BRPI0512916A - derivado de tienopirazol tendo atividade inibidora de pde 7 - Google Patents

derivado de tienopirazol tendo atividade inibidora de pde 7

Info

Publication number
BRPI0512916A
BRPI0512916A BRPI0512916-8A BRPI0512916A BRPI0512916A BR PI0512916 A BRPI0512916 A BR PI0512916A BR PI0512916 A BRPI0512916 A BR PI0512916A BR PI0512916 A BRPI0512916 A BR PI0512916A
Authority
BR
Brazil
Prior art keywords
pde
thienopyrazole
group
compound
inhibitory activity
Prior art date
Application number
BRPI0512916-8A
Other languages
English (en)
Inventor
Hidekazu Inoue
Hidenobu Murafuji
Yasuhiro Hayashi
Original Assignee
Daiichi Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Asubio Pharma Co Ltd filed Critical Daiichi Asubio Pharma Co Ltd
Publication of BRPI0512916A publication Critical patent/BRPI0512916A/pt
Publication of BRPI0512916B1 publication Critical patent/BRPI0512916B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P11/06—Antiasthmatics
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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Abstract

DERIVADO DE TIENOPIRAZOL TENDO ATIVIDADE INIBIDORA DE PDE 7. Para fornecer derivados de tienopirazol inibindo PDE 7 seletivamente, e portanto, intensificar o nível de cAMP celular. Por conseguinte, o composto é útil para tratar vários tipos de doença como doenças alérgicas, doenças inflamatórias ou doenças imunológicas. O composto é composto de tienopirazol representado pela fórmula (I) a seguir ¢em que, especialmente, R¬ 1 ¬ é uma clicloexila, um grupo cicloeptila ou um grupo tetraidropiranila; R¬ 2 ¬ é metila; R¬ 3 ¬ é um átomo de hidrogênio;. e R¬ 4 ¬ é um grupo: -CONR¬5¬R¬6¬ (em que qualquer um de R¬ 5 ¬ e R¬ 6 ¬ é um átomo de hidrogênio)!.
BRPI0512916-8A 2004-07-01 2005-07-01 Derivado de tienopirazol tendo atividade inibidora de pde 7 BRPI0512916B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004-195836 2004-07-01
JP2004195836 2004-07-01
PCT/JP2005/012208 WO2006004040A1 (ja) 2004-07-01 2005-07-01 Ｐｄｅ７阻害作用を有するチエノピラゾール誘導体

Publications (2)

Publication Number Publication Date
BRPI0512916A true BRPI0512916A (pt) 2008-04-15
BRPI0512916B1 BRPI0512916B1 (pt) 2020-09-15

Family

ID=35782844

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512916-8A BRPI0512916B1 (pt) 2004-07-01 2005-07-01 Derivado de tienopirazol tendo atividade inibidora de pde 7

Country Status (15)

Country Link
US (3) US7932250B2 (pt)
EP (2) EP2433943B1 (pt)
JP (3) JP4810426B2 (pt)
KR (1) KR101377844B1 (pt)
CN (2) CN1976938B (pt)
AU (1) AU2005258410B2 (pt)
BR (1) BRPI0512916B1 (pt)
CA (1) CA2569530C (pt)
DK (2) DK2433943T3 (pt)
ES (2) ES2437755T3 (pt)
MX (1) MX2007000214A (pt)
PL (2) PL2433943T3 (pt)
PT (1) PT1775298E (pt)
RU (1) RU2376309C2 (pt)
WO (1) WO2006004040A1 (pt)

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JP2006219374A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
JP2006219373A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
JP2005112840A (ja) * 2003-09-16 2005-04-28 Nissan Chem Ind Ltd 新規ピラゾールスルホニルウレア化合物および除草剤

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CN1976938A (zh) 2007-06-06
DK1775298T3 (da) 2013-05-21
PL1775298T3 (pl) 2013-08-30
US20090131413A1 (en) 2009-05-21
CN102827082A (zh) 2012-12-19
JP2011225604A (ja) 2011-11-10
CN1976938B (zh) 2012-08-15
EP1775298B1 (en) 2013-03-20
WO2006004040A1 (ja) 2006-01-12
JP5339639B2 (ja) 2013-11-13
JP4810426B2 (ja) 2011-11-09
JP5339638B2 (ja) 2013-11-13
MX2007000214A (es) 2007-05-10
ES2407811T3 (es) 2013-06-14
CA2569530A1 (en) 2006-01-12
ES2437755T3 (es) 2014-01-14
BRPI0512916B1 (pt) 2020-09-15
PT1775298E (pt) 2013-06-12
US7932250B2 (en) 2011-04-26
RU2007103815A (ru) 2008-08-10
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EP2433943A1 (en) 2012-03-28
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US8901315B2 (en) 2014-12-02
DK2433943T3 (da) 2013-12-16
RU2376309C2 (ru) 2009-12-20
AU2005258410B2 (en) 2011-12-22
AU2005258410A1 (en) 2006-01-12
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EP1775298A1 (en) 2007-04-18
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