BRPI0507052A - inibidores de quìnase - Google Patents

inibidores de quìnase

Info

Publication number
BRPI0507052A
BRPI0507052A BRPI0507052-0A BRPI0507052A BRPI0507052A BR PI0507052 A BRPI0507052 A BR PI0507052A BR PI0507052 A BRPI0507052 A BR PI0507052A BR PI0507052 A BRPI0507052 A BR PI0507052A
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
intermediates
derivatives
compositions
compounds
Prior art date
Application number
BRPI0507052-0A
Other languages
English (en)
Inventor
Michael J Hawkins
Michael N Greco
Eugene Powell
Lawrence De Garavilla
Bruce E Maryanoff
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0507052A publication Critical patent/BRPI0507052A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

INIBIDORES DE QUìNASE. A presente invenção refere-se a um composto da fórmula (I): a métodos para o preparo desses compostos, composições, intermediários e derivados dos mesmos e a método para o tratamento de distúrbios inflamatórios e mediados por protease de serina.
BRPI0507052-0A 2004-01-23 2005-01-18 inibidores de quìnase BRPI0507052A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53866304P 2004-01-23 2004-01-23
PCT/US2005/001659 WO2005073214A2 (en) 2004-01-23 2005-01-18 Novel inhibitors of chymase

Publications (1)

Publication Number Publication Date
BRPI0507052A true BRPI0507052A (pt) 2007-06-12

Family

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JP5404388B2 (ja) * 2006-05-10 2014-01-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 冷メントール受容体−１拮抗薬
US8629281B2 (en) 2011-01-14 2014-01-14 Janssen Pharmaceutica, Nv Cold menthol receptor-1 antagonists
JP5117382B2 (ja) 2006-05-31 2013-01-16 第一三共株式会社 ７員環化合物の製造方法
JP4986249B2 (ja) * 2006-10-06 2012-07-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チマーゼ阻害剤
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CN106467515B (zh) * 2015-08-18 2019-09-24 宁波洞密生物科技有限公司 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用
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CN108383875B (zh) * 2018-03-22 2020-04-28 昆明学院 一种银催化的3-膦酰甲基吲哚啉及制备方法
CN115873037A (zh) * 2022-11-30 2023-03-31 南通大学 一种膦化氮杂吲哚啉的合成方法

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MXPA06008375A (es) 2007-03-21
ZA200607024B (en) 2010-02-24
IL177037A (en) 2013-05-30
AR047448A1 (es) 2006-01-18
DE602005025600D1 (de) 2011-02-10
ECSP066721A (es) 2006-10-31
WO2005073214A3 (en) 2005-10-20
CA2554205C (en) 2013-08-27
ATE493421T1 (de) 2011-01-15
JP2007518807A (ja) 2007-07-12
EA011745B1 (ru) 2009-06-30
SG149880A1 (en) 2009-02-27
CR8563A (es) 2009-01-14
US20050176769A1 (en) 2005-08-11
WO2005073214A2 (en) 2005-08-11
CN101863923B (zh) 2013-04-24
KR20060129401A (ko) 2006-12-15
KR101182143B1 (ko) 2012-09-13
CN1934120A (zh) 2007-03-21
NO20063647L (no) 2006-10-19
HK1148753A1 (en) 2011-09-16
NZ548684A (en) 2009-04-30
ES2357013T3 (es) 2011-04-15
EP1716160A2 (en) 2006-11-02
IL177037A0 (en) 2006-12-10
CN1934120B (zh) 2010-05-26
US7459444B2 (en) 2008-12-02
US20090036409A1 (en) 2009-02-05
EA200601358A1 (ru) 2007-02-27
EP1716160B1 (en) 2010-12-29
CA2554205A1 (en) 2005-08-11
CN101863923A (zh) 2010-10-20
AU2005207856A1 (en) 2005-08-11
JP5022711B2 (ja) 2012-09-12
AU2005207856B2 (en) 2011-07-14

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