BRPI0418082A - antagonista de receptor de adenosina a2a, agente para tratar e/ou prevenir doenças, composto, composição farmacêutica, e, método para tratar e/ou prevenir doenças associadas com receptor de adenosina a2a - Google Patents

antagonista de receptor de adenosina a2a, agente para tratar e/ou prevenir doenças, composto, composição farmacêutica, e, método para tratar e/ou prevenir doenças associadas com receptor de adenosina a2a

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Publication number
BRPI0418082A
BRPI0418082A BRPI0418082-8A BRPI0418082A BRPI0418082A BR PI0418082 A BRPI0418082 A BR PI0418082A BR PI0418082 A BRPI0418082 A BR PI0418082A BR PI0418082 A BRPI0418082 A BR PI0418082A
Authority
BR
Brazil
Prior art keywords
substituted
adenosine
unsubstituted
treating
preventing diseases
Prior art date
Application number
BRPI0418082-8A
Other languages
English (en)
Inventor
Takao Nakajima
Masamori Sugawara
Shin-Ichi Uchida
Tetsuji Ohno
Yuji Nomoto
Noriaki Uesaka
Yoshisuke Nakasato
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of BRPI0418082A publication Critical patent/BRPI0418082A/pt
Publication of BRPI0418082B1 publication Critical patent/BRPI0418082B1/pt
Publication of BRPI0418082B8 publication Critical patent/BRPI0418082B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4965—Non-condensed pyrazines
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    • C07D513/04—Ortho-condensed systems

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Abstract

"ANTAGONISTA DE RECEPTOR DE ADENOSINA A~ 2A~, AGENTE PARA TRATAR E/OU PREVENIR DOENçAS, COMPOSTO, COMPOSIçãO FARMACêUTICA, E, MéTODO PARA TRATAR E/OU PREVENIR DOENçAS ASSOCIADAS COM RECEPTOR DE ADENOSINA A~ 2A~". Um antagonista de receptor de adenosina A~ 2A~ que contém como o ingrediente ativo, um derivado de tiazol representado por uma fórmula geral (1), ou um sal farmacologicamente aceitável do derivado, (em que n é um número inteiro de 0 a 3; R¬ 1¬ é cicloalquila substituído ou não substituído, arila substituído ou não substituído, um grupo heterocíclico alicíclico substituído ou não substituído, ou um grupo heterocíclico aromático substituído ou não substituído; R¬ 2¬ é halogênio, alquila inferior substituído ou não substituído, arila substituído ou não substituído, um grupo heterocíclico alicíclico substituído ou não substituído, um grupo heterocíclico aromático substituído ou não substituído, -COR¬ 8¬, ou análogos; R¬ 3¬ e R¬ 4¬ pode ser igual ou diferente, e cada um representa um átomo de hidrogênio, alquila inferior substituído ou não substituído, aralquila substituído ou não substituído, COR¬ 12¬, etc)
BRPI0418082A 2003-12-26 2004-12-24 derivados de tiazol úteis como antagonistas de receptor de adenosina a2a BRPI0418082B8 (pt)

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