BRPI0513267A - variantes melhoradas de aprotinina - Google Patents
variantes melhoradas de aprotininaInfo
- Publication number
- BRPI0513267A BRPI0513267A BRPI0513267-3A BRPI0513267A BRPI0513267A BR PI0513267 A BRPI0513267 A BR PI0513267A BR PI0513267 A BRPI0513267 A BR PI0513267A BR PI0513267 A BRPI0513267 A BR PI0513267A
- Authority
- BR
- Brazil
- Prior art keywords
- improved
- proteins
- field
- relates
- serine protease
- Prior art date
Links
- 108010039627 Aprotinin Proteins 0.000 title 1
- 229960004405 aprotinin Drugs 0.000 title 1
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 101710102218 Serine protease inhibitor Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
VARIANTES MELHORADAS DE APROTININA. A presente invenção refere-se ao campo de proteínas que inibem a atividade de serina protease. A invenção também refere-se ao campo de construtos de ácido nucléico, vetores e células hospedeiras para produzir proteínas inibidoras de serina proteases, composições farmacêuticas contendo tais proteínas e métodos para seu uso.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58765504P | 2004-07-13 | 2004-07-13 | |
| PCT/US2005/024951 WO2006017355A2 (en) | 2004-07-13 | 2005-07-13 | Improved aprotinin variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0513267A true BRPI0513267A (pt) | 2008-05-06 |
Family
ID=35839810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0513267-3A BRPI0513267A (pt) | 2004-07-13 | 2005-07-13 | variantes melhoradas de aprotinina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090005297A1 (pt) |
| EP (1) | EP1771464A4 (pt) |
| JP (1) | JP2008506391A (pt) |
| KR (1) | KR20070041749A (pt) |
| CN (1) | CN101014611A (pt) |
| AU (1) | AU2005271708A1 (pt) |
| BR (1) | BRPI0513267A (pt) |
| CA (1) | CA2573368A1 (pt) |
| EC (1) | ECSP077240A (pt) |
| IL (1) | IL180370A0 (pt) |
| MA (1) | MA28779B1 (pt) |
| MX (1) | MX2007000473A (pt) |
| NO (1) | NO20070640L (pt) |
| RU (1) | RU2007105137A (pt) |
| WO (1) | WO2006017355A2 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008110301A1 (de) * | 2007-03-13 | 2008-09-18 | Bayer Schering Pharma Aktiengesellschaft | Aprotinin-varianten mit verbesserten eigenschaften |
| WO2009030464A2 (de) * | 2007-09-08 | 2009-03-12 | Bayer Schering Pharma Aktiengesellschaft | HERSTELLUNG UND VERWENDUNG VON VARIANTEN HUMANER KUNITZ-TYP PROTEASE-INHIBITOREN (hKTPI) |
| CN101412995B (zh) * | 2007-10-17 | 2011-04-06 | 江苏正大天晴药业股份有限公司 | 聚乙二醇修饰的抑肽酶及其制备方法 |
| JP2012502906A (ja) * | 2008-09-17 | 2012-02-02 | ネクター セラピューティックス | オリゴマー−プロテアーゼ阻害剤コンジュゲート |
| WO2010088547A1 (en) * | 2009-01-29 | 2010-08-05 | Bayer Healthcare Llc | Assays for detecting pegylated blood coagulation factors |
| DE102011013326A1 (de) | 2011-03-08 | 2012-09-13 | Solution Shop Ag | Neue Fibrinolyse-Inhibitoren und deren mdizinische Verwendung |
| PL2822575T3 (pl) * | 2012-03-03 | 2020-08-10 | Immungene, Inc. | Zmodyfikowane sposobami inżynierii cząsteczki fuzyjne przeciwciało-mutant interferonu |
| US9605057B1 (en) * | 2013-06-17 | 2017-03-28 | Board Of Regents Of The University Of Texas System | Endotrophin neutralization and use thereof |
| US20180362616A1 (en) * | 2015-12-10 | 2018-12-20 | The National Institute for Biotechnology in the Negev Ltd. | VARIANTS OF AMYLOID beta-PROTEIN PRECURSOR INHIBITOR DOMAIN |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69233760D1 (de) * | 1991-03-01 | 2009-06-25 | Dyax Corp | Inhibitoren der menschlichen Elastase von Neutrophilen |
| IL104314A0 (en) * | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
-
2005
- 2005-07-13 RU RU2007105137/13A patent/RU2007105137A/ru not_active Application Discontinuation
- 2005-07-13 CN CNA2005800302602A patent/CN101014611A/zh active Pending
- 2005-07-13 KR KR1020077003345A patent/KR20070041749A/ko not_active Withdrawn
- 2005-07-13 BR BRPI0513267-3A patent/BRPI0513267A/pt not_active IP Right Cessation
- 2005-07-13 EP EP05791407A patent/EP1771464A4/en not_active Withdrawn
- 2005-07-13 WO PCT/US2005/024951 patent/WO2006017355A2/en not_active Ceased
- 2005-07-13 JP JP2007521627A patent/JP2008506391A/ja not_active Withdrawn
- 2005-07-13 MX MX2007000473A patent/MX2007000473A/es unknown
- 2005-07-13 AU AU2005271708A patent/AU2005271708A1/en not_active Abandoned
- 2005-07-13 CA CA002573368A patent/CA2573368A1/en not_active Abandoned
- 2005-07-13 US US11/659,434 patent/US20090005297A1/en not_active Abandoned
-
2006
- 2006-12-26 IL IL180370A patent/IL180370A0/en unknown
-
2007
- 2007-02-01 MA MA29646A patent/MA28779B1/fr unknown
- 2007-02-05 NO NO20070640A patent/NO20070640L/no not_active Application Discontinuation
- 2007-02-12 EC EC2007007240A patent/ECSP077240A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070041749A (ko) | 2007-04-19 |
| CN101014611A (zh) | 2007-08-08 |
| JP2008506391A (ja) | 2008-03-06 |
| IL180370A0 (en) | 2007-06-03 |
| EP1771464A2 (en) | 2007-04-11 |
| MX2007000473A (es) | 2007-03-29 |
| AU2005271708A1 (en) | 2006-02-16 |
| MA28779B1 (fr) | 2007-08-01 |
| WO2006017355A2 (en) | 2006-02-16 |
| NO20070640L (no) | 2007-04-11 |
| RU2007105137A (ru) | 2008-08-20 |
| US20090005297A1 (en) | 2009-01-01 |
| WO2006017355A3 (en) | 2006-12-14 |
| ECSP077240A (es) | 2007-03-29 |
| EP1771464A4 (en) | 2008-09-03 |
| CA2573368A1 (en) | 2006-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP077240A (es) | Variantes mejoradas de la aprotinina | |
| MX2010001481A (es) | Proteasas fungales acidas. | |
| BR0309671A (pt) | ácidos de piperidinil- e piperazinil-sulfonilmetil hidroxâmicos e seu uso como inibidores de protease | |
| SE0201980D0 (sv) | Novel compounds | |
| MX2010004371A (es) | Proteasa de streptomyces. | |
| EA200800670A1 (ru) | Ингибиторы сериновых протеаз | |
| MX2009013085A (es) | Metodos para mejorar el desempeño de la proteina. | |
| SE0201976D0 (sv) | Novel compounds | |
| ATE420879T1 (de) | Indolizine als kinaseproteinhemmer | |
| WO2003066824A3 (en) | Albumin-fused kunitz domain peptides | |
| NO20081013L (no) | 7-substituerte aza-indazoler, sammensetninger inneholdende disse, produksjonsmetode og anvendelse derav | |
| GEP20104974B (en) | Carbonylamino pyrrolopyrazoles, protent kinase inhibitors | |
| TW200637843A (en) | Phenylglycinamide derivatives useful as anticoagulants | |
| TR199902751T2 (xx) | Proteaz inhibit�rleri. | |
| ATE350470T1 (de) | Durch thrombin spaltbare chimäre proteine | |
| SE0201977D0 (sv) | Novel compounds | |
| NO20076448L (no) | Novel piperidine carboxylic acid amide derivatives | |
| BRPI0618654A8 (pt) | variante de zimogênio/protease de fator x/fator xa, ácido nucléico, composição farmacêutica que os contém, vetor, bem como uso dos mesmos | |
| BRPI0517035A (pt) | novos compostos | |
| EP1828404A4 (en) | DEVICES AND METHOD FOR DETERMINING PROTEASE ACTIVITY | |
| ATE340257T1 (de) | Histonedeacetylase 9 | |
| SE0203712D0 (sv) | Novel compounds | |
| BRPI0517033A (pt) | novos derivados de hidantoìna como inibidores de metaloproteinase | |
| EA200800357A1 (ru) | Новые фармацевтические соединения | |
| BRPI0507613A (pt) | expressão de plasminogênio e microplasminogênio em lentilha d'água |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |