MA28779B1 - Variants d'aprotinine ameliores - Google Patents

Variants d'aprotinine ameliores

Info

Publication number
MA28779B1
MA28779B1 MA29646A MA29646A MA28779B1 MA 28779 B1 MA28779 B1 MA 28779B1 MA 29646 A MA29646 A MA 29646A MA 29646 A MA29646 A MA 29646A MA 28779 B1 MA28779 B1 MA 28779B1
Authority
MA
Morocco
Prior art keywords
aprotinine
variants
improved
proteins
field
Prior art date
Application number
MA29646A
Other languages
English (en)
Inventor
Kevin Lumb
Stanley Horton
Original Assignee
Bayer Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp
Publication of MA28779B1 publication Critical patent/MA28779B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention se rapporte au domaine des protéines qui inhibent l'activité de la serine protéase. L'invention se rapporte également au domaine des constructions d'acide nucléique, aux vecteurs et aux cellules hôtes pour la production des protéines inhibitrices de la serine protéase, à des compositions pharmaceutiques contenant de telles protéines, et aux méthodes de leur utilisation.
MA29646A 2004-07-13 2007-02-01 Variants d'aprotinine ameliores MA28779B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58765504P 2004-07-13 2004-07-13

Publications (1)

Publication Number Publication Date
MA28779B1 true MA28779B1 (fr) 2007-08-01

Family

ID=35839810

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29646A MA28779B1 (fr) 2004-07-13 2007-02-01 Variants d'aprotinine ameliores

Country Status (15)

Country Link
US (1) US20090005297A1 (fr)
EP (1) EP1771464A4 (fr)
JP (1) JP2008506391A (fr)
KR (1) KR20070041749A (fr)
CN (1) CN101014611A (fr)
AU (1) AU2005271708A1 (fr)
BR (1) BRPI0513267A (fr)
CA (1) CA2573368A1 (fr)
EC (1) ECSP077240A (fr)
IL (1) IL180370A0 (fr)
MA (1) MA28779B1 (fr)
MX (1) MX2007000473A (fr)
NO (1) NO20070640L (fr)
RU (1) RU2007105137A (fr)
WO (1) WO2006017355A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008110301A1 (fr) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Variants d'aprotinine à propriétés améliorées
WO2009030464A2 (fr) * 2007-09-08 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Préparation et utilisation de variantes d'inhibiteurs de protéase du type kunitz humains (hktpi)
CN101412995B (zh) * 2007-10-17 2011-04-06 江苏正大天晴药业股份有限公司 聚乙二醇修饰的抑肽酶及其制备方法
WO2010033226A1 (fr) * 2008-09-17 2010-03-25 Nektar Therapeutics Conjugués inhibiteurs de protéase-oligomère
WO2010088547A1 (fr) * 2009-01-29 2010-08-05 Bayer Healthcare Llc Dosages de détection de facteurs de coagulation sanguine pégylés
DE102011013326A1 (de) 2011-03-08 2012-09-13 Solution Shop Ag Neue Fibrinolyse-Inhibitoren und deren mdizinische Verwendung
ES2800426T3 (es) * 2012-03-03 2020-12-30 Immungene Inc Moléculas de fusión anticuerpos-mutante de interferón modificadas
US9605057B1 (en) * 2013-06-17 2017-03-28 Board Of Regents Of The University Of Texas System Endotrophin neutralization and use thereof
CN108699134A (zh) * 2015-12-10 2018-10-23 国家生物技术研究所公司 淀粉样β-蛋白前体抑制剂结构域的变体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2105304C (fr) * 1991-03-01 2005-10-04 Arthur C. Ley Inhibiteurs de l'elastase de neutrophile humaine et de la cathepsin g humaine
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP1771464A2 (fr) 2007-04-11
JP2008506391A (ja) 2008-03-06
EP1771464A4 (fr) 2008-09-03
CA2573368A1 (fr) 2006-02-16
US20090005297A1 (en) 2009-01-01
BRPI0513267A (pt) 2008-05-06
KR20070041749A (ko) 2007-04-19
NO20070640L (no) 2007-04-11
AU2005271708A1 (en) 2006-02-16
MX2007000473A (es) 2007-03-29
IL180370A0 (en) 2007-06-03
ECSP077240A (es) 2007-03-29
WO2006017355A2 (fr) 2006-02-16
CN101014611A (zh) 2007-08-08
RU2007105137A (ru) 2008-08-20
WO2006017355A3 (fr) 2006-12-14

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