CR8842A - Derivados de pirido-pirimidina, su preparacion, su aplicacion en terapeutica - Google Patents

Derivados de pirido-pirimidina, su preparacion, su aplicacion en terapeutica

Info

Publication number
CR8842A
CR8842A CR8842A CR8842A CR8842A CR 8842 A CR8842 A CR 8842A CR 8842 A CR8842 A CR 8842A CR 8842 A CR8842 A CR 8842A CR 8842 A CR8842 A CR 8842A
Authority
CR
Costa Rica
Prior art keywords
preparation
therapeutics
derivatives
application
pirimidina
Prior art date
Application number
CR8842A
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Samir Jegham
Pierre Perreaut
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CR8842A publication Critical patent/CR8842A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion tiene por objeto derivados de pirido[2,3-dlpirimidina. su preparacion y su aplicacion en terapeutica, de formula general (I) que sigue: Formula (I) en estado de base o de sal de adicion a un acido tarmaceuticamente aceptable, en estado de hidratos o de solvatos, asi como en torma de enantiorneros, de diaestereoisorneros y su mezcla. La invencion tiene igualmente por objeto su procedimiento de preparacion, las composiciones farmaceuticas que contienen un compuesto de formula general (1), y su utilizacion en el tratamiento del cancer.
CR8842A 2004-07-15 2007-01-09 Derivados de pirido-pirimidina, su preparacion, su aplicacion en terapeutica CR8842A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0407898A FR2873118B1 (fr) 2004-07-15 2004-07-15 Derives de pyrido-pyrimidine, leur application en therapeutique

Publications (1)

Publication Number Publication Date
CR8842A true CR8842A (es) 2007-08-28

Family

ID=34947008

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8842A CR8842A (es) 2004-07-15 2007-01-09 Derivados de pirido-pirimidina, su preparacion, su aplicacion en terapeutica

Country Status (28)

Country Link
US (2) US7544682B2 (es)
EP (1) EP1773835B1 (es)
JP (1) JP5161568B2 (es)
KR (1) KR101236676B1 (es)
CN (1) CN101124223A (es)
AR (1) AR049845A1 (es)
AU (1) AU2005271071B2 (es)
BR (1) BRPI0513287A (es)
CA (1) CA2572614A1 (es)
CR (1) CR8842A (es)
EA (1) EA011406B1 (es)
EC (1) ECSP067111A (es)
FR (1) FR2873118B1 (es)
GT (1) GT200500191A (es)
HN (1) HN2005000370A (es)
IL (1) IL180256A (es)
MA (1) MA28742B1 (es)
MX (1) MX2007000508A (es)
NO (1) NO20070837L (es)
PA (1) PA8639301A1 (es)
PE (1) PE20060380A1 (es)
SV (1) SV2006002170A (es)
TN (1) TNSN06440A1 (es)
TW (1) TWI391390B (es)
UA (1) UA95223C2 (es)
UY (1) UY29015A1 (es)
WO (1) WO2006016067A2 (es)
ZA (1) ZA200700992B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
JP4975739B2 (ja) * 2005-05-17 2012-07-11 シェーリング コーポレイション 脂質異常症の処置のための、ニコチン酸受容体アゴニストとしての複素環
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
MX2008009413A (es) * 2006-01-20 2008-10-01 Schering Corp Heterociclos como agonistas del receptor de acido nicotinico para el tratamiento de la dislipidemia.
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
CN101784551A (zh) * 2007-06-15 2010-07-21 万有制药株式会社 二环苯胺衍生物
FR2933701A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
RU2191188C2 (ru) 1994-11-14 2002-10-20 Варнер-Ламберт Компани Производные 6-арилпиридо[2,3-d]-пиримидины и -нафтиридины, фармацевтическая композиция, обладающая ингибирующим действием клеточной пролиферации, вызываемой протеиновой тирозинкиназой, и способ ингибирования клеточной пролиферации
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
WO2001021577A2 (en) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
CA2397961C (en) 2000-01-25 2008-08-26 Richard John Booth Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
YU66502A (sh) 2000-03-06 2005-09-19 Warner-Lambert Company 5-alkilpirido(2,3-d)pirimidini, inhibitori tirozinkinaza
ES2311532T3 (es) 2000-08-04 2009-02-16 Warner-Lambert Company Llc 2-(4-pirdil)amino-6-dialcoxifenil-pirido(2.3-d)pirimidin-7-onas.
AU2002324450A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
WO2003026665A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4-(5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
CN1293078C (zh) * 2002-04-03 2007-01-03 霍夫曼-拉罗奇有限公司 咪唑并稠合化合物
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
WO2004063195A1 (en) 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
US7449582B2 (en) * 2003-10-08 2008-11-11 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.

Also Published As

Publication number Publication date
TNSN06440A1 (fr) 2008-02-22
EP1773835A2 (fr) 2007-04-18
KR101236676B1 (ko) 2013-02-22
ECSP067111A (es) 2007-01-26
IL180256A (en) 2014-04-30
TWI391390B (zh) 2013-04-01
GT200500191A (es) 2006-03-07
BRPI0513287A (pt) 2008-05-06
NO20070837L (no) 2007-04-16
EP1773835B1 (fr) 2014-09-24
US7544682B2 (en) 2009-06-09
HN2005000370A (es) 2009-06-01
UY29015A1 (es) 2006-02-24
CA2572614A1 (fr) 2006-02-16
PE20060380A1 (es) 2006-06-06
EA011406B1 (ru) 2009-02-27
PA8639301A1 (es) 2006-11-09
JP2008506673A (ja) 2008-03-06
CN101124223A (zh) 2008-02-13
MX2007000508A (es) 2007-03-29
FR2873118B1 (fr) 2007-11-23
WO2006016067A3 (fr) 2006-06-01
AR049845A1 (es) 2006-09-06
AU2005271071A1 (en) 2006-02-16
MA28742B1 (fr) 2007-07-02
AU2005271071B2 (en) 2011-09-15
JP5161568B2 (ja) 2013-03-13
FR2873118A1 (fr) 2006-01-20
KR20070037489A (ko) 2007-04-04
IL180256A0 (en) 2007-07-04
ZA200700992B (en) 2008-05-28
US20090233923A1 (en) 2009-09-17
SV2006002170A (es) 2006-01-13
UA95223C2 (ru) 2011-07-25
WO2006016067A2 (fr) 2006-02-16
US20070167469A1 (en) 2007-07-19
TW200607808A (en) 2006-03-01
US7893259B2 (en) 2011-02-22
EA200700144A1 (ru) 2007-08-31

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