BRPI0513359A - tetraidroisoquinolinas substituìdas por arila e heteroarila e uso destes para bloquear a recaptação de norepinefrina, dopamina, e serotonina - Google Patents

tetraidroisoquinolinas substituìdas por arila e heteroarila e uso destes para bloquear a recaptação de norepinefrina, dopamina, e serotonina

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Publication number
BRPI0513359A
BRPI0513359A BRPI0513359-9A BRPI0513359A BRPI0513359A BR PI0513359 A BRPI0513359 A BR PI0513359A BR PI0513359 A BRPI0513359 A BR PI0513359A BR PI0513359 A BRPI0513359 A BR PI0513359A
Authority
BR
Brazil
Prior art keywords
pyridinyl
quinolinyl
quinazinyl
benzo
serotonin
Prior art date
Application number
BRPI0513359-9A
Other languages
English (en)
Inventor
Bruce F Molino
Shuang Liu
Barry A Berkowitz
Peter R Guzzo
James P Beck
Marlene Cohen
Original Assignee
Amr Technology Inc
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc, Bristol Myers Squibb Co filed Critical Amr Technology Inc
Publication of BRPI0513359A publication Critical patent/BRPI0513359A/pt

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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Abstract

TETRAIDROISOQUINOLINAS SUBSTITUìDAS POR ARILA E HETEROARILA E USO DESTES PARA BLOQUEAR A RECAPTAçãO DE NOREPINEFRINA, DOPAMINA, E SEROTONINA. A presente invenção refere-se aos compostos da presente invenção que são representados pela estrutura química encontrada na Fórmula (I): em que: o átomo de carbono designado * está na configuração R ou S; e X é um carbociclo bicíclico fundido ou heterociclo selecionado do grupo que consiste em benzofuranila, benzo¢b!tiofenila, benzoisotiazolila, benzoisoxazolila, indazolila, indolila, isoindolila, indolizinila, benzoimidazolila, benzooxazolila, benzotiazolila, benzotriazolila, imidazo¢1 ,2-a! piridinila, pirazol¢1 .5-a! piridinila, ¢1 ,2,4!triazol¢4,3-a!piridinila, tieno¢2,3-b! piridinila, tieno ¢3,2-b! piridinila, 1 H-pirrol¢2,3-b!piridinila, indenila, indanila, diidrobenzocicloeptenila, tetraidrobenzocicloeptenila, diidrobenzotiofenila, diidrobenzofuranila, indolinila, naftila, tetraidronaifila, quinolinila, isoquinolinila, 4H-quinolizinila, 9aH-quinolizinila, quinazolinila, cinolinila, ftalazinila, quinoxalinila, benzo ¢1 ,2,3!triazinila, benzo¢1 ,2,4!triazinila, 2H- cromenila, 4H-cromenila, e um carbociclo bicíclico fundido ou heterociclo bicíclico fundido opcionalmente substituído por substituintes (número 1 a 4) como definido em R¬ 14¬com R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬ R¬ 7¬, R¬ 8¬, e R¬ 14¬ definidos aqui.
BRPI0513359-9A 2004-07-15 2005-07-15 tetraidroisoquinolinas substituìdas por arila e heteroarila e uso destes para bloquear a recaptação de norepinefrina, dopamina, e serotonina BRPI0513359A (pt)

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