BRPI0513996A - processo para a identificação de compostos para modular a atividade de um transportador trocador de sódio/cálcio - Google Patents

processo para a identificação de compostos para modular a atividade de um transportador trocador de sódio/cálcio

Info

Publication number
BRPI0513996A
BRPI0513996A BRPI0513996-1A BRPI0513996A BRPI0513996A BR PI0513996 A BRPI0513996 A BR PI0513996A BR PI0513996 A BRPI0513996 A BR PI0513996A BR PI0513996 A BRPI0513996 A BR PI0513996A
Authority
BR
Brazil
Prior art keywords
activity
modulate
sodium
identifying compounds
calcium exchanger
Prior art date
Application number
BRPI0513996-1A
Other languages
English (en)
Inventor
Henning Vollert
Sven Geibel
Bela Kelety
Wolfgang Doerner
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of BRPI0513996A publication Critical patent/BRPI0513996A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCESSO PARA A IDENTIFICAçãO DE COMPOSTOS PARA MODULAR A ATIVIDADE DE UM TRANSPORTADOR TROCADOR DE SóDIO/CáLCIO. A invenção se refere a um ensaio sem células para a determinação da atividade de uma proteína trocadora de Na¬ +¬/Ca²¬ +¬ (NCX) através de um circuito integrado de sensor eletrofisiológico sem células, um kit de partes compreendendo o circuito integrado do sensor com uma proteína NCX assim como a produção e o uso do kit de partes.
BRPI0513996-1A 2004-08-19 2005-08-10 processo para a identificação de compostos para modular a atividade de um transportador trocador de sódio/cálcio BRPI0513996A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04019635 2004-08-19
PCT/EP2005/008660 WO2006018197A1 (en) 2004-08-19 2005-08-10 Process for identification of compounds for modulating the activity of a sodium/calcium exchange transporter

Publications (1)

Publication Number Publication Date
BRPI0513996A true BRPI0513996A (pt) 2008-05-20

Family

ID=34926217

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513996-1A BRPI0513996A (pt) 2004-08-19 2005-08-10 processo para a identificação de compostos para modular a atividade de um transportador trocador de sódio/cálcio

Country Status (12)

Country Link
US (1) US8026069B2 (pt)
EP (1) EP1782064B1 (pt)
JP (1) JP5331339B2 (pt)
KR (1) KR101241846B1 (pt)
CN (1) CN101036054B (pt)
AT (1) ATE542134T1 (pt)
AU (1) AU2005274399B2 (pt)
BR (1) BRPI0513996A (pt)
CA (1) CA2577463C (pt)
IL (1) IL181157A (pt)
MX (1) MX2007001656A (pt)
WO (1) WO2006018197A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2103939A1 (en) * 2008-03-20 2009-09-23 sanofi-aventis Fluorescence based assay to detect sodium/calcium exchanger (NCX) "reverse mode" modulating compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1351023A (zh) * 2000-10-26 2002-05-29 上海博德基因开发有限公司 一种新的多肽——视网膜杆状钠－钙+钾离子交换器11.33和编码这种多肽的多核苷酸
DE10112505C1 (de) 2001-03-15 2003-01-30 Iongate Biosciences Gmbh Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung
DE10244129B4 (de) * 2002-09-23 2006-04-20 Iongate Biosciences Gmbh H+-K+-ATPase-Assay

Also Published As

Publication number Publication date
HK1107144A1 (en) 2008-03-28
US20080211485A1 (en) 2008-09-04
CA2577463C (en) 2013-08-06
JP5331339B2 (ja) 2013-10-30
CN101036054A (zh) 2007-09-12
IL181157A0 (en) 2007-07-04
JP2008510150A (ja) 2008-04-03
WO2006018197A1 (en) 2006-02-23
IL181157A (en) 2013-03-24
AU2005274399B2 (en) 2010-09-23
US8026069B2 (en) 2011-09-27
EP1782064A1 (en) 2007-05-09
KR20070043013A (ko) 2007-04-24
ATE542134T1 (de) 2012-02-15
EP1782064B1 (en) 2012-01-18
CN101036054B (zh) 2013-03-06
CA2577463A1 (en) 2006-02-23
AU2005274399A1 (en) 2006-02-23
KR101241846B1 (ko) 2013-03-12
MX2007001656A (es) 2007-04-23

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]