BRPI0514191A - compostos que potencializam o receptor glutamato e seus usos em medicina - Google Patents

compostos que potencializam o receptor glutamato e seus usos em medicina

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Publication number
BRPI0514191A
BRPI0514191A BRPI0514191-5A BRPI0514191A BRPI0514191A BR PI0514191 A BRPI0514191 A BR PI0514191A BR PI0514191 A BRPI0514191 A BR PI0514191A BR PI0514191 A BRPI0514191 A BR PI0514191A
Authority
BR
Brazil
Prior art keywords
alkyl
dialkylamine
haloalkyl
alkoxy
compounds
Prior art date
Application number
BRPI0514191-5A
Other languages
English (en)
Inventor
Daniel Marcus Bradley
Kevin Michael Thewlis
Simon Edward Ward
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0417708A external-priority patent/GB0417708D0/en
Priority claimed from GB0508473A external-priority patent/GB0508473D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BRPI0514191A publication Critical patent/BRPI0514191A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

COMPOSTOS QUE POTENCIALIZAM O RECEPTOR GLUTAMATO E SEUS USOS EM MEDICINA Compostos de fórmula (I) ou um seu sal, solvato ou prodroga são revelados: onde R¬ 1¬ é alquila(C~ 1~-C~ 6~), haloalquila (C~ 1~-C~ 6~), alquenila (C~ 2~-C~ 6~), amino, monoalquilamina(C~ 1~-C~ 4~) ou dialquilamina(C~ 1~-C~ 4~); R¬ 2¬ e R¬ 3¬, que podem ser iguais ou diferentes, são hidrogênio, halogênio, alquila (C~ 1~-C~ 6~), haloalquila (C~ 1~-C~ 6~), alcoxila (C~ 1~-C~ 4~), haloalcoxila(C~ 1~-C~ 4~), ciano, amino, ou dialquilamina(C~ 1~-C~ 4~); cada R¬ 4¬, que podem ser iguais ou diferentes, é alquila(C~ 1~-C~ 6~), halogênio, alquila (C~ 1~-C~ 6~), haloalquila (C~ 1~-C~ 6~), ou dialquilamina(C~ 1~-C~ 4~); p é 0, 1. ou 2; n é 1 ou 2; R¬ 05¬ e R¬ 6¬, que podem ser iguais ou diferentes, são hidrogênio, halogênio, alquila (C~ 1~-C~ 6~), haloalquila (C~ 1~-C~ 6~), alcoxila (C~ 1~-C~ 4~), haloalcoxila(C~ 1~-C~ 4~), ciano, amino, monoalquilamina(C~ 1~-C~ 4~) ou dialquilamina(C~ 1~-C~ 4~); e Het é tienila, piridila, pirimidinila, piridazinila, pirimidinila, pirazinila, imidazolila, pirazolila, pirrolila, quinolila, tiazolila ou furila, cada um dos quais pode estar substituído com um ou mais grupos independentemente selecionados a partir da lista que consiste de alquila(C~ 1~-C~ 6~), alcoxila(C~ 1~-C~ 6~), acetila, halogênio, haloalquila(C~ 1~-C~ 6~), ciano, nitro, amino, monoalquilamina(C~ 1~-C~ 4~) e dialquilamina(C~ 1~-C~ 4~). Métodos de preparação dos compostos, e seus usos em medicina, por exemplo, para o tratamento da esquizofrenia, são também revelados.
BRPI0514191-5A 2004-08-09 2005-08-05 compostos que potencializam o receptor glutamato e seus usos em medicina BRPI0514191A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0417708A GB0417708D0 (en) 2004-08-09 2004-08-09 Compounds
GB0508473A GB0508473D0 (en) 2005-04-26 2005-04-26 Compounds
PCT/EP2005/008562 WO2006015828A1 (en) 2004-08-09 2005-08-05 Compounds which potentiate glutamate receptor and uses thereof in medicine

Publications (1)

Publication Number Publication Date
BRPI0514191A true BRPI0514191A (pt) 2008-06-03

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KR100659088B1 (ko) * 2005-07-15 2006-12-21 삼성에스디아이 주식회사 디플루오로피리딘계 화합물 및 이를 이용한 유기 발광 소자
TW200812975A (en) 2006-03-20 2008-03-16 Glaxo Group Ltd Compounds which potentiate AMPA receptor and uses thereof in medicine
EP2086643B1 (en) 2006-11-03 2011-03-23 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine
GB0704939D0 (en) * 2007-03-14 2007-04-25 Glaxo Group Ltd Compounds
WO2008113795A1 (en) * 2007-03-20 2008-09-25 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine
GB0711089D0 (en) * 2007-06-08 2007-07-18 Glaxo Group Ltd Compounds
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JP2011506551A (ja) 2007-12-19 2011-03-03 グラクソ グループ リミテッド Ａｍｐａ受容体増強化合物および医薬におけるその使用
TW201012803A (en) 2008-06-06 2010-04-01 Organon Nv Heterocyclic derivatives
GB0818071D0 (en) * 2008-10-02 2008-11-05 Glaxo Group Ltd Compounds
GB0821166D0 (en) * 2008-11-19 2008-12-24 Glaxo Group Ltd Compounds
GB0822425D0 (en) * 2008-12-09 2009-01-14 Glaxo Group Ltd Compounds
CN102365265A (zh) * 2009-04-09 2012-02-29 欧加农股份有限公司 2，3-二氢化茚衍生物
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WO2013075624A1 (zh) 2011-11-22 2013-05-30 北京哈三联科技股份有限公司 甘氨酸重摄取抑制剂及其应用
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WO2016092547A1 (en) 2014-12-09 2016-06-16 Ezekiel Golan Alcoholic beverage substitutes
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JPH07233072A (ja) * 1993-12-28 1995-09-05 Tanabe Seiyaku Co Ltd 医薬組成物
EP1115393A4 (en) * 1998-07-31 2002-03-26 Lilly Co Eli Sulfonamide derivatives
PE20000944A1 (es) * 1998-07-31 2000-09-20 Lilly Co Eli Derivados de sulfonamida
TW593241B (en) * 1999-04-20 2004-06-21 Hoffmann La Roche Carbamic acid derivatives
MXPA01011003A (es) * 1999-04-30 2002-06-04 Lilly Co Eli Derivados de monofluoroalquilo.
ES2225558T3 (es) * 2000-06-13 2005-03-16 Eli Lilly And Company Derivados de sulfonamida.
ATE298742T1 (de) * 2001-05-30 2005-07-15 Lilly Co Eli Zykloalkenylsulfonamidderivate
BRPI0514191A (pt) * 2004-08-09 2008-06-03 Glaxo Group Ltd compostos que potencializam o receptor glutamato e seus usos em medicina

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TW200619197A (en) 2006-06-16
EP1781614B1 (en) 2009-06-24
EP1944289B1 (en) 2010-05-19
ATE434608T1 (de) 2009-07-15
AU2005270377A1 (en) 2006-02-16
CN101035760A (zh) 2007-09-12
JP2008509180A (ja) 2008-03-27
RU2007108536A (ru) 2008-09-20
JP4901735B2 (ja) 2012-03-21
EP1781614A1 (en) 2007-05-09
ATE468326T1 (de) 2010-06-15
RU2403242C2 (ru) 2010-11-10
EP1944289A1 (en) 2008-07-16
ES2346017T3 (es) 2010-10-07
IL181172A0 (en) 2007-07-04
NZ552979A (en) 2010-02-26
KR20070050070A (ko) 2007-05-14
ES2329063T3 (es) 2009-11-20
US20070161638A1 (en) 2007-07-12
US7572819B2 (en) 2009-08-11
MX2007001678A (es) 2007-04-12
WO2006015828A1 (en) 2006-02-16
NO20071234L (no) 2007-05-08
AR050208A1 (es) 2006-10-04
PE20060623A1 (es) 2006-07-01
DE602005021407D1 (de) 2010-07-01
CA2576254A1 (en) 2006-02-16
DE602005015119D1 (de) 2009-08-06
MA28823B1 (fr) 2007-08-01
CN101035760B (zh) 2011-03-02
US7618969B2 (en) 2009-11-17
US20080194648A1 (en) 2008-08-14

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