BRPI0514397A - derivados de 3-ariltioindol-2-carboxamida e análogos destes como inibidores de caseìna cinase iépsilon - Google Patents
derivados de 3-ariltioindol-2-carboxamida e análogos destes como inibidores de caseìna cinase iépsilonInfo
- Publication number
- BRPI0514397A BRPI0514397A BRPI0514397-7A BRPI0514397A BRPI0514397A BR PI0514397 A BRPI0514397 A BR PI0514397A BR PI0514397 A BRPI0514397 A BR PI0514397A BR PI0514397 A BRPI0514397 A BR PI0514397A
- Authority
- BR
- Brazil
- Prior art keywords
- sleep
- disorder
- casein kinase
- inhibitors
- carboxamide derivatives
- Prior art date
Links
- 102000005403 Casein Kinases Human genes 0.000 title abstract 3
- 108010031425 Casein Kinases Proteins 0.000 title abstract 3
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 208000019116 sleep disease Diseases 0.000 abstract 4
- 208000020925 Bipolar disease Diseases 0.000 abstract 2
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000020685 sleep-wake disease Diseases 0.000 abstract 2
- 208000011580 syndromic disease Diseases 0.000 abstract 2
- 201000007034 advanced sleep phase syndrome Diseases 0.000 abstract 1
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000008632 circadian clock Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
DERIVADOS DE 3-ARILTIOINDOL-2-CARBOXAMIDA E ANáLOGOS DESTES COMO INIBIDORES DE CASEìNA CINASE IéPSILON. A presente invenção se refere a métodos para tratar um paciente sofrendo de doenças ou distúrbios do sistema nervoso central associados com o distúrbio do relógio circadiano humano que são melhorados por inibição de atividade de caseína cinase Ie tal como, por exemplo, transtornos do sono incluindo transtorno depressivo maior, transtorno bipolar I e transtorno bipolar II, e distúrbios do sono incluindo distúrbio do sono do ritmo circadiano tal como, por exemplo, distúrbio do sono de trabalho por turnos, síndrome de dessincronose, síndrome da fase do sono avançado e síndrome da fase do sono retardado, compreendendo administrar ao referido paciente uma quantidade terapeuticamente eficaz de um composto da fórmula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60334804P | 2004-08-19 | 2004-08-19 | |
| PCT/US2005/029306 WO2006023590A1 (en) | 2004-08-19 | 2005-08-19 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0514397A true BRPI0514397A (pt) | 2008-06-10 |
Family
ID=35311784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0514397-7A BRPI0514397A (pt) | 2004-08-19 | 2005-08-19 | derivados de 3-ariltioindol-2-carboxamida e análogos destes como inibidores de caseìna cinase iépsilon |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8008340B2 (pt) |
| EP (1) | EP1791537B1 (pt) |
| JP (1) | JP4931814B2 (pt) |
| KR (1) | KR20070045264A (pt) |
| CN (1) | CN101039666A (pt) |
| AT (1) | ATE445396T1 (pt) |
| AU (1) | AU2005277460A1 (pt) |
| BR (1) | BRPI0514397A (pt) |
| CA (1) | CA2577511A1 (pt) |
| DE (1) | DE602005017162D1 (pt) |
| DK (1) | DK1791537T3 (pt) |
| ES (1) | ES2334927T3 (pt) |
| IL (1) | IL181155A0 (pt) |
| MX (1) | MX2007001077A (pt) |
| PL (1) | PL1791537T3 (pt) |
| PT (1) | PT1791537E (pt) |
| RU (1) | RU2391098C2 (pt) |
| SI (1) | SI1791537T1 (pt) |
| WO (1) | WO2006023590A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102007100A (zh) * | 2008-02-22 | 2011-04-06 | Irm责任有限公司 | 作为gpr119活性调控剂的化合物和组合物 |
| EP2397481B1 (en) * | 2009-02-12 | 2014-03-12 | Pharmadesign, Inc. | Inhibitor of casein kinase 1delta and casein kinase 1epsilon |
| DK2493876T3 (en) * | 2009-10-28 | 2014-03-10 | Pfizer | Imidazole derivatives AS casein kinase inhibitors |
| CA2797281A1 (en) * | 2010-05-06 | 2011-11-10 | Merck Sharp & Dohme Corp. | Aza-indole derivatives useful as modulators of faah |
| EP2604606B1 (en) * | 2010-08-09 | 2014-10-08 | Pharmadesign, Inc. | Inhibitor of casein kinase 1delta and casein kinase 1epsilon |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| US20140031547A1 (en) * | 2010-12-14 | 2014-01-30 | Electrophoretics Limited | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES |
| CN104640856B (zh) * | 2012-05-11 | 2017-09-15 | 复位治疗公司 | 作为隐花色素调节剂的含有咔唑的磺酰胺类 |
| TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
| WO2018133835A1 (en) * | 2017-01-20 | 2018-07-26 | National Institute Of Biological Sciences, Beijing | Nucleoside analogue regulating mammalian circadian rhythm |
| WO2021164770A1 (en) * | 2020-02-21 | 2021-08-26 | Peking University | Agents and methods for adjusting sleep |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3705934A1 (de) * | 1987-02-25 | 1988-09-08 | Nattermann A & Cie | Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPH08507067A (ja) * | 1993-02-24 | 1996-07-30 | メルク エンド カンパニー インコーポレーテッド | Ｈｉｖ逆転写酵素阻害剤 |
| US5807693A (en) * | 1994-11-23 | 1998-09-15 | Icos Corporation | Calcineurin inhibitory compounds and anchoring protein |
| KR100722176B1 (ko) * | 1999-06-08 | 2007-05-29 | 아벤티스 파마슈티칼스 인크. | 일주기 리듬 단백질을 변화시키기 위한 스크리닝 방법 |
| CA2478715A1 (en) * | 2002-03-13 | 2003-09-25 | Pharmacia & Upjohn Company | Novel pyrazolo [1,5-a]pyridine derivatives and their use as neurotransmitter modulators |
| WO2004005501A1 (en) * | 2002-07-08 | 2004-01-15 | Bayer Healthcare Ag | Regulation of human casein kinase i epsilon |
| US20060128783A1 (en) * | 2002-08-09 | 2006-06-15 | Dinsmore Christopher J | Tyrosine kinase inhibitors |
| DE602004020685D1 (de) * | 2003-12-11 | 2009-05-28 | Aventis Pharma Inc | Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3-cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i-epsilon |
-
2005
- 2005-08-19 AU AU2005277460A patent/AU2005277460A1/en not_active Abandoned
- 2005-08-19 ES ES05785433T patent/ES2334927T3/es not_active Expired - Lifetime
- 2005-08-19 BR BRPI0514397-7A patent/BRPI0514397A/pt not_active IP Right Cessation
- 2005-08-19 KR KR1020077003924A patent/KR20070045264A/ko not_active Withdrawn
- 2005-08-19 JP JP2007527987A patent/JP4931814B2/ja not_active Expired - Fee Related
- 2005-08-19 WO PCT/US2005/029306 patent/WO2006023590A1/en not_active Ceased
- 2005-08-19 CA CA002577511A patent/CA2577511A1/en not_active Abandoned
- 2005-08-19 DE DE602005017162T patent/DE602005017162D1/de not_active Expired - Lifetime
- 2005-08-19 DK DK05785433.3T patent/DK1791537T3/da active
- 2005-08-19 CN CNA2005800346526A patent/CN101039666A/zh active Pending
- 2005-08-19 AT AT05785433T patent/ATE445396T1/de not_active IP Right Cessation
- 2005-08-19 PL PL05785433T patent/PL1791537T3/pl unknown
- 2005-08-19 SI SI200530889T patent/SI1791537T1/sl unknown
- 2005-08-19 MX MX2007001077A patent/MX2007001077A/es not_active Application Discontinuation
- 2005-08-19 EP EP05785433A patent/EP1791537B1/en not_active Expired - Lifetime
- 2005-08-19 RU RU2007109813/14A patent/RU2391098C2/ru not_active IP Right Cessation
- 2005-08-19 PT PT05785433T patent/PT1791537E/pt unknown
-
2007
- 2007-02-04 IL IL181155A patent/IL181155A0/en unknown
- 2007-02-15 US US11/675,230 patent/US8008340B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101039666A (zh) | 2007-09-19 |
| US20070142454A1 (en) | 2007-06-21 |
| RU2391098C2 (ru) | 2010-06-10 |
| EP1791537A1 (en) | 2007-06-06 |
| ES2334927T3 (es) | 2010-03-17 |
| JP2008510704A (ja) | 2008-04-10 |
| KR20070045264A (ko) | 2007-05-02 |
| IL181155A0 (en) | 2007-07-04 |
| DE602005017162D1 (de) | 2009-11-26 |
| US8008340B2 (en) | 2011-08-30 |
| SI1791537T1 (sl) | 2010-02-26 |
| AU2005277460A1 (en) | 2006-03-02 |
| MX2007001077A (es) | 2007-04-17 |
| WO2006023590A1 (en) | 2006-03-02 |
| DK1791537T3 (da) | 2010-03-01 |
| JP4931814B2 (ja) | 2012-05-16 |
| PT1791537E (pt) | 2010-01-19 |
| CA2577511A1 (en) | 2006-03-02 |
| ATE445396T1 (de) | 2009-10-15 |
| PL1791537T3 (pl) | 2010-04-30 |
| EP1791537B1 (en) | 2009-10-14 |
| RU2007109813A (ru) | 2008-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: AVENTIS PHARMACEUTICALS, INC. (US) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |