ECSP088329A - Nuevos diazaespiroalcanos y su uso para el tratamiento de enfermedades mediadas por ccr8 - Google Patents

Nuevos diazaespiroalcanos y su uso para el tratamiento de enfermedades mediadas por ccr8

Info

Publication number
ECSP088329A
ECSP088329A EC2008008329A ECSP088329A ECSP088329A EC SP088329 A ECSP088329 A EC SP088329A EC 2008008329 A EC2008008329 A EC 2008008329A EC SP088329 A ECSP088329 A EC SP088329A EC SP088329 A ECSP088329 A EC SP088329A
Authority
EC
Ecuador
Prior art keywords
diazaespiroalcanos
ccr8
treatment
new
diseases mediated
Prior art date
Application number
EC2008008329A
Other languages
English (en)
Inventor
Stephen Connolly
Lena Boerjesson
Henrik Johansson
Anna Kristoffersson
Tero Linnanen
Igor Shamovsky
Marco Skrinjar
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ECSP088329A publication Critical patent/ECSP088329A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención provee compuestos de la fórmula general (I), en donde A, B, p, w, x, y y z tienen las definiciones indicadas en la descripción, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia.
EC2008008329A 2005-09-06 2008-03-28 Nuevos diazaespiroalcanos y su uso para el tratamiento de enfermedades mediadas por ccr8 ECSP088329A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0501967 2005-09-06

Publications (1)

Publication Number Publication Date
ECSP088329A true ECSP088329A (es) 2008-04-28

Family

ID=37836107

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008329A ECSP088329A (es) 2005-09-06 2008-03-28 Nuevos diazaespiroalcanos y su uso para el tratamiento de enfermedades mediadas por ccr8

Country Status (17)

Country Link
US (1) US20090156575A1 (es)
EP (1) EP1926730A4 (es)
JP (1) JP2009507070A (es)
KR (1) KR20080043396A (es)
CN (1) CN101305005A (es)
AR (1) AR055630A1 (es)
AU (1) AU2006287976A1 (es)
BR (1) BRPI0615634A2 (es)
CA (1) CA2621187A1 (es)
EC (1) ECSP088329A (es)
IL (1) IL189528A0 (es)
NO (1) NO20081729L (es)
RU (1) RU2008110915A (es)
TW (1) TW200800999A (es)
UY (1) UY29781A1 (es)
WO (1) WO2007030061A1 (es)
ZA (1) ZA200801511B (es)

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BR112017026682A2 (pt) 2015-09-24 2018-08-14 Hoffmann La Roche novos compostos bicíclicos como inibidores de dupla ação de atx/ca
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AU2017359023B2 (en) * 2016-11-08 2021-12-09 Bristol-Myers Squibb Company 3-substituted propionic acids as alpha v integrin inhibitors
CN108456208B (zh) * 2017-02-22 2021-04-16 广州市恒诺康医药科技有限公司 氮杂螺环类化合物及其制备方法和应用
CN106928092B (zh) * 2017-02-28 2019-02-15 上海微巨实业有限公司 一种间氰甲基苯甲酸甲酯的制备方法
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JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ.ホフマン-ラ ロシュ アーゲー Atxインヒビターとしての新規二環式化合物
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
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EP3758695A4 (en) 2018-02-28 2021-10-06 The Trustees Of The University Of Pennsylvania POLY (AD-RIBOSE) -POLYMERASE 1 DEPENDENT CYTOTOXIC AGENTS WITH LOW AFFINITY
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Also Published As

Publication number Publication date
CA2621187A1 (en) 2007-03-15
JP2009507070A (ja) 2009-02-19
TW200800999A (en) 2008-01-01
BRPI0615634A2 (pt) 2011-05-24
ZA200801511B (en) 2008-11-26
EP1926730A4 (en) 2011-02-16
AU2006287976A1 (en) 2007-03-15
NO20081729L (no) 2008-05-16
CN101305005A (zh) 2008-11-12
RU2008110915A (ru) 2009-10-20
UY29781A1 (es) 2007-04-30
AR055630A1 (es) 2007-08-29
IL189528A0 (en) 2008-08-07
KR20080043396A (ko) 2008-05-16
US20090156575A1 (en) 2009-06-18
WO2007030061A1 (en) 2007-03-15
EP1926730A1 (en) 2008-06-04

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