BRPI0516001A - formas cristalinas de 3-[5-cloro-4-[(2, 4-difluorobenzil) óxi]-6-oxopirimidin-1(6h)-il]-n-(2-hidroxietil)-4-metilben zamida - Google Patents

formas cristalinas de 3-[5-cloro-4-[(2, 4-difluorobenzil) óxi]-6-oxopirimidin-1(6h)-il]-n-(2-hidroxietil)-4-metilben zamida

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Publication number
BRPI0516001A
BRPI0516001A BRPI0516001-4A BRPI0516001A BRPI0516001A BR PI0516001 A BRPI0516001 A BR PI0516001A BR PI0516001 A BRPI0516001 A BR PI0516001A BR PI0516001 A BRPI0516001 A BR PI0516001A
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BR
Brazil
Prior art keywords
crystalline forms
difluorobenzyl
hydroxyethyl
chloro
oxopyrimidin
Prior art date
Application number
BRPI0516001-4A
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English (en)
Inventor
Jong G Selbo
Original Assignee
Pharmacia & Upjohn Co Llc
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Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0516001A publication Critical patent/BRPI0516001A/pt

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

"FORMAS CRISTALINAS DE 3-¢5-CLORO-4-¢(2,4- DIFLUOROBENZIL)óXI!-6-OXOPIRIMIDIN-1 (6H)-IL!-N-(2-HIDROXIETIL)-4- METILBENZAMIDA". A presente invenção refere-se a formas cristalinas do inibidor de quinase p38 3-¢5-cloro-4-¢(2,4-difluorobenzil) óxi!-6-oxopirimidin-1(6H)-il!-N-(2-hidroxietil)-4-metilbenzamida. A invenção refere-se também a combinações e composições farmacêuticas compreendendo as formas cristalinas e métodos para a profilaxia e/ou tratamento de uma condição mediada pela quinase p38 compreendendo administração, a um indivíduo, de uma quantidade terapeuticamente eficaz das formas cristalinas.
BRPI0516001-4A 2004-10-13 2005-10-03 formas cristalinas de 3-[5-cloro-4-[(2, 4-difluorobenzil) óxi]-6-oxopirimidin-1(6h)-il]-n-(2-hidroxietil)-4-metilben zamida BRPI0516001A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61846604P 2004-10-13 2004-10-13
PCT/IB2005/003030 WO2006040649A1 (en) 2004-10-13 2005-10-03 Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6h)-yl]-n-(2-hydroxyethyl)-4-methylbenzamide

Publications (1)

Publication Number Publication Date
BRPI0516001A true BRPI0516001A (pt) 2008-08-19

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BRPI0516001-4A BRPI0516001A (pt) 2004-10-13 2005-10-03 formas cristalinas de 3-[5-cloro-4-[(2, 4-difluorobenzil) óxi]-6-oxopirimidin-1(6h)-il]-n-(2-hidroxietil)-4-metilben zamida

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US (2) US8324230B2 (pt)
EP (2) EP2708531A1 (pt)
JP (1) JP4937129B2 (pt)
KR (1) KR100872675B1 (pt)
CN (1) CN101039921A (pt)
AR (1) AR051384A1 (pt)
AU (1) AU2005293290A1 (pt)
BR (1) BRPI0516001A (pt)
CA (1) CA2584246C (pt)
ES (1) ES2463681T3 (pt)
IL (1) IL181815A0 (pt)
MX (1) MX2007004514A (pt)
NO (1) NO20072445L (pt)
TW (1) TWI303633B (pt)
WO (1) WO2006040649A1 (pt)
ZA (1) ZA200701999B (pt)

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Publication number Priority date Publication date Assignee Title
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
NZ594064A (en) * 2009-01-30 2012-08-31 Glaxosmithkline Llc Crystalline n-{ (1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl} -5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
MY192644A (en) 2009-11-27 2022-08-29 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
BR112013017722A2 (pt) 2011-01-11 2016-07-12 Glaxosmithkline Llc combinação
KR101252711B1 (ko) * 2011-03-31 2013-04-09 김두철 가구용 경첩
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CA2584246A1 (en) 2006-04-20
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