NO20072445L - Krystallinske former av 3-[5-klor-4-[(2,4-difluorbenzyl)oksy]-6-oksypyrimidin-1 (6H)-yl]-N-(2-hydroksyetyl)-4-metylbenzamid - Google Patents

Krystallinske former av 3-[5-klor-4-[(2,4-difluorbenzyl)oksy]-6-oksypyrimidin-1 (6H)-yl]-N-(2-hydroksyetyl)-4-metylbenzamid

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Publication number
NO20072445L
NO20072445L NO20072445A NO20072445A NO20072445L NO 20072445 L NO20072445 L NO 20072445L NO 20072445 A NO20072445 A NO 20072445A NO 20072445 A NO20072445 A NO 20072445A NO 20072445 L NO20072445 L NO 20072445L
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Norway
Prior art keywords
crystalline forms
difluorobenzyl
methylbenzamide
oxy
hydroxyethyl
Prior art date
Application number
NO20072445A
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English (en)
Inventor
Jon Gordon Selbo
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of NO20072445L publication Critical patent/NO20072445L/no

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

Det beskrives krystallinske former av p38 kinaseinhiboren 3-[5-klor-4-[(2,4-difluorbenzyl)oksy] -6-oksopyrimidin-1 (6H)-yl] -N-(2-hydroksyetyl)-4-metylbenzamid. Det tilveiebringes videre kombinasjoner og farmasøytiske preparater omfattende de krystallinske former og metoder for profylakse og/eller terapi av en p38 kinasemediert tilstand ved administrering til et individ av en terapeutisk effektiv mengde av den krystallinske form.
NO20072445A 2004-10-13 2007-05-11 Krystallinske former av 3-[5-klor-4-[(2,4-difluorbenzyl)oksy]-6-oksypyrimidin-1 (6H)-yl]-N-(2-hydroksyetyl)-4-metylbenzamid NO20072445L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61846604P 2004-10-13 2004-10-13
PCT/IB2005/003030 WO2006040649A1 (en) 2004-10-13 2005-10-03 Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6h)-yl]-n-(2-hydroxyethyl)-4-methylbenzamide

Publications (1)

Publication Number Publication Date
NO20072445L true NO20072445L (no) 2007-07-09

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NO20072445A NO20072445L (no) 2004-10-13 2007-05-11 Krystallinske former av 3-[5-klor-4-[(2,4-difluorbenzyl)oksy]-6-oksypyrimidin-1 (6H)-yl]-N-(2-hydroksyetyl)-4-metylbenzamid

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US (2) US8324230B2 (no)
EP (2) EP1802589B1 (no)
JP (1) JP4937129B2 (no)
KR (1) KR100872675B1 (no)
CN (1) CN101039921A (no)
AR (1) AR051384A1 (no)
AU (1) AU2005293290A1 (no)
BR (1) BRPI0516001A (no)
CA (1) CA2584246C (no)
ES (1) ES2463681T3 (no)
IL (1) IL181815A0 (no)
MX (1) MX2007004514A (no)
NO (1) NO20072445L (no)
TW (1) TWI303633B (no)
WO (1) WO2006040649A1 (no)
ZA (1) ZA200701999B (no)

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FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
CA2750565C (en) * 2009-01-30 2015-10-20 Glaxosmithkline Llc Crystalline n-{(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
SG10201407881WA (en) 2009-11-27 2015-01-29 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
SG10201600077RA (en) 2011-01-11 2016-02-26 Glaxosmithkline Llc Combination
KR101252711B1 (ko) * 2011-03-31 2013-04-09 김두철 가구용 경첩
ES2716008T3 (es) 2012-07-18 2019-06-07 Sunshine Lake Pharma Co Ltd Derivados heterocíclicos nitrogenados y su aplicación en fármacos
US9902712B2 (en) 2013-12-19 2018-02-27 Sunshine Lake Pharma Co., Ltd. Nitrogenous heterocyclic derivatives and their application in drugs
MX2021014157A (es) * 2019-05-23 2022-01-04 Novartis Ag Formas cristalinas de un inhibidor btk.

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JPS61205261A (ja) 1985-03-08 1986-09-11 Sagami Chem Res Center ６―置換―５―フルオロウラシル誘導体
JPH09504010A (ja) 1993-10-20 1997-04-22 ジ・アップジョン・カンパニー 抗関節炎剤および抗炎症剤としてのピリミジノン
HUP0001140A3 (en) 1996-12-05 2002-05-28 Amgen Inc Thousand Oaks Substituted pyrimidinone and pyridone compounds and methods of use
WO1999064400A1 (en) 1998-06-12 1999-12-16 Vertex Pharmaceuticals Incorporated INHIBITORS OF p38
AU2247701A (en) * 1999-10-21 2001-04-30 Merck & Co., Inc. Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment
JP2006500351A (ja) 2002-08-13 2006-01-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体
US20070167621A1 (en) * 2003-04-03 2007-07-19 Pharmacia Corporation Substituted pyrimidinones
US7183287B2 (en) * 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones

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