BRPI0516106A - método para a limpeza de derivados de 3-hidroxiamidinofenilalanina pela precipitação e recristalização de sal e um ácido sulfÈnico aromático - Google Patents
método para a limpeza de derivados de 3-hidroxiamidinofenilalanina pela precipitação e recristalização de sal e um ácido sulfÈnico aromáticoInfo
- Publication number
- BRPI0516106A BRPI0516106A BRPI0516106-1A BRPI0516106A BRPI0516106A BR PI0516106 A BRPI0516106 A BR PI0516106A BR PI0516106 A BRPI0516106 A BR PI0516106A BR PI0516106 A BRPI0516106 A BR PI0516106A
- Authority
- BR
- Brazil
- Prior art keywords
- recrystallization
- precipitation
- cleaning
- salt
- sulfonic acid
- Prior art date
Links
- QDTWPUMDDXFCHL-QMMMGPOBSA-N (2S)-2-amino-3-[3-(N'-hydroxycarbamimidoyl)phenyl]propanoic acid Chemical class OC(=O)[C@@H](N)CC1=CC=CC(C(=N)NO)=C1 QDTWPUMDDXFCHL-QMMMGPOBSA-N 0.000 title abstract 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000001953 recrystallisation Methods 0.000 title 1
- 238000005185 salting out Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- NIOKQPJRXDRREF-QMMMGPOBSA-N (2s)-2-amino-3-(3-carbamimidoylphenyl)propanoic acid Chemical class OC(=O)[C@@H](N)CC1=CC=CC(C(N)=N)=C1 NIOKQPJRXDRREF-QMMMGPOBSA-N 0.000 abstract 1
- 239000002797 plasminogen activator inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Detergent Compositions (AREA)
Abstract
MéTODO PARA A LIMPEZA DE DERIVADOS DE 3-HIDROXIAMIDINOFENILALANINA PELA PRECIPITAçãO E RECRISTALIZAçãO DE SAL E UM áCIDO SULFÈNICO AROMáTICO. A presente invenção refere-se a preparação de derivados de 3-hidroxiamidinofenilalanina em uma forma altamente pura que pode ser usada, por exemplo, como inibidores da uroquinase. A presente invenção ainda refere-se ao uso de derivados de 3-hidroxiamidinofenilalanina de alta pureza para a preparação de derivados de 3-amidinofenilalanina.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04024553 | 2004-10-14 | ||
| EP04024553.2 | 2004-10-14 | ||
| PCT/EP2005/010970 WO2006042678A1 (de) | 2004-10-14 | 2005-10-14 | Verfahren zur reinigung von 3-hydroxy-amidino-phenylalanin-derivaten durch ausfällung und umkristallisation eines salzes mit einer aromatischen sulfonsäure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0516106A true BRPI0516106A (pt) | 2008-08-26 |
| BRPI0516106B1 BRPI0516106B1 (pt) | 2021-08-24 |
Family
ID=35462142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0516106-1A BRPI0516106B1 (pt) | 2004-10-14 | 2005-10-14 | Métodos para purificação e preparação de derivados de 3-hidroxiamidinofenilalanina, e para produção de derivados de 3-amidinofenilalanina |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7951943B2 (pt) |
| EP (1) | EP1799665B1 (pt) |
| JP (1) | JP5096157B2 (pt) |
| KR (1) | KR101106652B1 (pt) |
| CN (1) | CN101039928B (pt) |
| AT (1) | ATE440092T1 (pt) |
| AU (1) | AU2005297610B2 (pt) |
| BR (1) | BRPI0516106B1 (pt) |
| CA (1) | CA2583771C (pt) |
| DE (1) | DE502005007959D1 (pt) |
| ES (1) | ES2328052T3 (pt) |
| MX (1) | MX2007004191A (pt) |
| RU (1) | RU2391336C2 (pt) |
| SG (1) | SG156645A1 (pt) |
| WO (1) | WO2006042678A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117695284B (zh) | 2020-03-10 | 2025-06-17 | 红山生物医药有限公司 | 冠状病毒感染的治疗 |
| US11471448B2 (en) | 2020-12-15 | 2022-10-18 | Redhill Biopharma Ltd. | Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4375430A (en) * | 1981-09-08 | 1983-03-01 | Pfizer Inc. | Processes for preparation, isolation and purification of dipeptide sweeteners |
| JPH10237030A (ja) * | 1997-02-26 | 1998-09-08 | Ajinomoto Co Inc | 分岐鎖アミノ酸の精製法 |
| DE19743435A1 (de) * | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
| DE50211672D1 (de) * | 2001-03-21 | 2008-03-27 | Wilex Ag | Urokinase-inhibitoren |
| SI21137A (sl) * | 2002-01-24 | 2003-08-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Derivati azafenilalanina |
| CH695999A5 (de) * | 2002-02-28 | 2006-11-15 | Wilex Ag | Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten. |
-
2005
- 2005-10-14 BR BRPI0516106-1A patent/BRPI0516106B1/pt not_active IP Right Cessation
- 2005-10-14 ES ES05790930T patent/ES2328052T3/es not_active Expired - Lifetime
- 2005-10-14 US US11/576,978 patent/US7951943B2/en not_active Expired - Fee Related
- 2005-10-14 CA CA2583771A patent/CA2583771C/en not_active Expired - Fee Related
- 2005-10-14 CN CN2005800350199A patent/CN101039928B/zh not_active Expired - Fee Related
- 2005-10-14 WO PCT/EP2005/010970 patent/WO2006042678A1/de not_active Ceased
- 2005-10-14 KR KR1020077010741A patent/KR101106652B1/ko not_active Expired - Fee Related
- 2005-10-14 MX MX2007004191A patent/MX2007004191A/es active IP Right Grant
- 2005-10-14 AU AU2005297610A patent/AU2005297610B2/en not_active Ceased
- 2005-10-14 AT AT05790930T patent/ATE440092T1/de active
- 2005-10-14 SG SG200906861-0A patent/SG156645A1/en unknown
- 2005-10-14 RU RU2007117751/04A patent/RU2391336C2/ru active
- 2005-10-14 DE DE502005007959T patent/DE502005007959D1/de not_active Expired - Lifetime
- 2005-10-14 JP JP2007536080A patent/JP5096157B2/ja not_active Expired - Fee Related
- 2005-10-14 EP EP05790930A patent/EP1799665B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE502005007959D1 (de) | 2009-10-01 |
| CN101039928B (zh) | 2010-12-08 |
| JP5096157B2 (ja) | 2012-12-12 |
| ES2328052T3 (es) | 2009-11-06 |
| US20080039626A1 (en) | 2008-02-14 |
| US20090099360A9 (en) | 2009-04-16 |
| CA2583771C (en) | 2013-08-27 |
| JP2008516908A (ja) | 2008-05-22 |
| CA2583771A1 (en) | 2006-04-27 |
| HK1101170A1 (zh) | 2007-10-12 |
| KR20070063591A (ko) | 2007-06-19 |
| US7951943B2 (en) | 2011-05-31 |
| KR101106652B1 (ko) | 2012-01-18 |
| AU2005297610B2 (en) | 2011-05-19 |
| SG156645A1 (en) | 2009-11-26 |
| EP1799665B1 (de) | 2009-08-19 |
| BRPI0516106B1 (pt) | 2021-08-24 |
| EP1799665A1 (de) | 2007-06-27 |
| AU2005297610A1 (en) | 2006-04-27 |
| MX2007004191A (es) | 2007-06-11 |
| RU2391336C2 (ru) | 2010-06-10 |
| ATE440092T1 (de) | 2009-09-15 |
| CN101039928A (zh) | 2007-09-19 |
| WO2006042678A1 (de) | 2006-04-27 |
| RU2007117751A (ru) | 2008-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: WILEX AG (DE) Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020080117818/RJ DE 08/09/2008. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 295/20 , C07C 311/19 , C07C 303/40 Ipc: C07D 295/20 (2006.01), C07C 311/19 (2006.01), C07C |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/10/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 18A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2744 DE 08-08-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |