BRPI0516337A - processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmos - Google Patents
processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmosInfo
- Publication number
- BRPI0516337A BRPI0516337A BRPI0516337-4A BRPI0516337A BRPI0516337A BR PI0516337 A BRPI0516337 A BR PI0516337A BR PI0516337 A BRPI0516337 A BR PI0516337A BR PI0516337 A BRPI0516337 A BR PI0516337A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- benzyloxyphenylthio
- hydrates
- chlorophenyl
- ethyl
- Prior art date
Links
- MYIFLDFUXIHOCJ-UHFFFAOYSA-N 2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol;hydrochloride Chemical compound Cl.C1=C(Cl)C(CCC(CO)(CO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 MYIFLDFUXIHOCJ-UHFFFAOYSA-N 0.000 title 1
- 150000004677 hydrates Chemical class 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004297651 | 2004-10-12 | ||
| PCT/JP2005/018602 WO2006041019A1 (ja) | 2004-10-12 | 2005-10-07 | 2-アミノ-2-[2-[4-(3-ベンジルオキシフェニルチオ)-2-クロロフェニル]エチル]-1,3-プロパンジオール塩酸塩又はその水和物の製造方法及びその製造中間体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0516337A true BRPI0516337A (pt) | 2008-04-29 |
Family
ID=36148313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0516337-4A BRPI0516337A (pt) | 2004-10-12 | 2005-10-07 | processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7795472B2 (pt) |
| EP (2) | EP2511262B1 (pt) |
| JP (1) | JP4792400B2 (pt) |
| KR (1) | KR101181090B1 (pt) |
| CN (2) | CN101880250B (pt) |
| AU (1) | AU2005292984B2 (pt) |
| BR (1) | BRPI0516337A (pt) |
| CA (1) | CA2583846C (pt) |
| ES (2) | ES2563034T3 (pt) |
| MX (1) | MX2007004319A (pt) |
| PL (2) | PL2511262T3 (pt) |
| PT (1) | PT2511262T (pt) |
| RU (1) | RU2376285C2 (pt) |
| WO (1) | WO2006041019A1 (pt) |
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| ATE502630T1 (de) | 2004-07-16 | 2011-04-15 | Kyorin Seiyaku Kk | Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen |
| AU2005292984B2 (en) | 2004-10-12 | 2011-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same |
| RU2421214C2 (ru) * | 2005-10-07 | 2011-06-20 | Киорин Фармасьютикал Ко., Лтд. | Терапевтическое средство для лечения гепатита и способ лечения гепатита |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| JP5140593B2 (ja) * | 2006-08-08 | 2013-02-06 | 杏林製薬株式会社 | アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤 |
| US8232319B2 (en) * | 2006-08-08 | 2012-07-31 | Kyorin Pharmaceutical Co., Ltd. | Amino phosphate derivative and S1P receptor modulator having same as an active ingredient |
| WO2008078563A1 (ja) * | 2006-12-22 | 2008-07-03 | Sumitomo Seika Chemicals Co., Ltd. | ３－ベンジルオキシベンゼンチオールの製造方法 |
| TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
| CN106366027A (zh) | 2008-03-24 | 2017-02-01 | 杏林制药株式会社 | 2‑氨基‑2‑[2‑[4‑（3‑苄氧基苯硫基）‑2‑氯苯基]乙基]‑1，3‑丙二醇盐酸盐的结晶化方法 |
| CA2724450A1 (en) * | 2008-05-19 | 2009-11-26 | Takeshi Tsubuki | Method for producing optically active aminoalcohol derivative |
| JP5330066B2 (ja) * | 2009-04-13 | 2013-10-30 | 富士フイルム株式会社 | トリアリールアミン化合物の製造方法 |
| WO2012073249A1 (en) | 2010-12-01 | 2012-06-07 | Arch Pharmalabs Limited | A novel process for the preparation of 3-(benzyloxy)- benzenethiol, a key intermediate for the preparation of pharmaceutical drugs. |
| ES2665312T3 (es) * | 2012-04-18 | 2018-04-25 | Kyorin Pharmaceutical Co., Ltd. | Cristal de 4-(3 -benciloxifeniltio) - 2-cloro-1-(3 -nitropropil)benceno |
| CN102718662A (zh) * | 2012-07-12 | 2012-10-10 | 杭州新博思生物医药有限公司 | 一种制备盐酸西那卡塞的方法 |
| CN103113270A (zh) * | 2012-11-26 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 一种4-（3-苄氧基-苯基硫烷基）-2-氯-1-乙烯基苯的合成方法 |
| CN108017928A (zh) * | 2017-12-15 | 2018-05-11 | 淮海工学院 | 一种用于生物分子标记的聚乙二醇化吲哚菁染料及其制备方法 |
| CN112512516A (zh) | 2018-07-27 | 2021-03-16 | 普瑞奥治疗有限公司 | 用于在已经经历造血干细胞移植的患者中抑制血液恶性肿瘤复发的活性剂 |
| KR20230136603A (ko) | 2021-01-28 | 2023-09-26 | 프리오테라 에스에이에스 | S1p 수용체 조정제를 사용한 치료 방법 |
| WO2022162409A1 (en) | 2021-01-28 | 2022-08-04 | Priothera Sas | Methods of treatment with s1p receptor modulators |
| TW202341971A (zh) | 2022-02-16 | 2023-11-01 | 法商普萊歐塞拉公司 | 使用car細胞及s1p受體調節劑之治療方法 |
| EP4282407A1 (en) | 2022-05-27 | 2023-11-29 | Priothera SAS | Treatment of cancer with s1p receptor agonists |
| WO2025109119A1 (en) | 2023-11-22 | 2025-05-30 | Priothera Sas | Methods of treatment with multispecific antigen-binding proteins in combination with s1p receptor modulators |
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-
2005
- 2005-10-07 AU AU2005292984A patent/AU2005292984B2/en not_active Ceased
- 2005-10-07 PT PT121671754T patent/PT2511262T/pt unknown
- 2005-10-07 WO PCT/JP2005/018602 patent/WO2006041019A1/ja not_active Ceased
- 2005-10-07 RU RU2007117372/04A patent/RU2376285C2/ru not_active IP Right Cessation
- 2005-10-07 CN CN2010101975227A patent/CN101880250B/zh not_active Expired - Fee Related
- 2005-10-07 US US11/665,058 patent/US7795472B2/en not_active Expired - Fee Related
- 2005-10-07 PL PL12167175T patent/PL2511262T3/pl unknown
- 2005-10-07 PL PL05790615T patent/PL1806338T3/pl unknown
- 2005-10-07 ES ES05790615.8T patent/ES2563034T3/es not_active Expired - Lifetime
- 2005-10-07 BR BRPI0516337-4A patent/BRPI0516337A/pt not_active IP Right Cessation
- 2005-10-07 JP JP2006540913A patent/JP4792400B2/ja not_active Expired - Fee Related
- 2005-10-07 ES ES12167175.4T patent/ES2615498T3/es not_active Expired - Lifetime
- 2005-10-07 MX MX2007004319A patent/MX2007004319A/es active IP Right Grant
- 2005-10-07 EP EP12167175.4A patent/EP2511262B1/en not_active Expired - Lifetime
- 2005-10-07 CA CA2583846A patent/CA2583846C/en not_active Expired - Lifetime
- 2005-10-07 KR KR1020077010572A patent/KR101181090B1/ko not_active Expired - Fee Related
- 2005-10-07 CN CN2005800417574A patent/CN101072752B/zh not_active Expired - Fee Related
- 2005-10-07 EP EP05790615.8A patent/EP1806338B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1806338B1 (en) | 2016-01-20 |
| RU2007117372A (ru) | 2008-11-20 |
| US20080207941A1 (en) | 2008-08-28 |
| US7795472B2 (en) | 2010-09-14 |
| CN101880250B (zh) | 2013-04-03 |
| MX2007004319A (es) | 2007-06-15 |
| PL1806338T3 (pl) | 2016-07-29 |
| EP1806338A1 (en) | 2007-07-11 |
| WO2006041019A1 (ja) | 2006-04-20 |
| JPWO2006041019A1 (ja) | 2008-05-15 |
| CN101880250A (zh) | 2010-11-10 |
| AU2005292984A1 (en) | 2006-04-20 |
| PL2511262T3 (pl) | 2017-08-31 |
| PT2511262T (pt) | 2017-03-30 |
| ES2615498T3 (es) | 2017-06-07 |
| ES2563034T3 (es) | 2016-03-10 |
| KR101181090B1 (ko) | 2012-09-07 |
| JP4792400B2 (ja) | 2011-10-12 |
| EP2511262A1 (en) | 2012-10-17 |
| CA2583846C (en) | 2013-10-01 |
| RU2376285C2 (ru) | 2009-12-20 |
| AU2005292984B2 (en) | 2011-01-20 |
| KR20070073895A (ko) | 2007-07-10 |
| CA2583846A1 (en) | 2006-04-20 |
| EP1806338A4 (en) | 2009-12-16 |
| CN101072752B (zh) | 2010-12-08 |
| CN101072752A (zh) | 2007-11-14 |
| EP2511262B1 (en) | 2017-02-01 |
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