BRPI0516373A - derivados de pirido(3,2-d)pirimidinas e uso dos mesmos - Google Patents
derivados de pirido(3,2-d)pirimidinas e uso dos mesmosInfo
- Publication number
- BRPI0516373A BRPI0516373A BRPI0516373-0A BRPI0516373A BRPI0516373A BR PI0516373 A BRPI0516373 A BR PI0516373A BR PI0516373 A BRPI0516373 A BR PI0516373A BR PI0516373 A BRPI0516373 A BR PI0516373A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- derivatives
- useful
- treatment
- pyrido
- Prior art date
Links
- 159000000017 pyrido[3,2-d]pyrimidines Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- BWESROVQGZSBRX-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine Chemical class C1=NC=NC2=CC=CN=C21 BWESROVQGZSBRX-UHFFFAOYSA-N 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
DERIVADOS DE PIRIDO(3,2-D)PIRIMIDINAS E USO DOS MESMOS. A presente invenção refere-se a derivados de pirido (3,2-d) pirimidina substituídos, seus sais farmaceuticamente aceitáveis, N-óxidos, solvatos, pró drogas e enantiómeros, possuindo propriedades farmacêuticas inesperadamente desejáveis, em particular os quais são agentes imunossupressores altamente ativos, e como tais são úteis no tratamento na rejeição de transplante e/ou no tratamento de certas doenças inflamatórias. Estes derivados são também úteis na prevenção ou tratamento de distúrbios cardiovasculares, distúrbios do sistema nervoso central, distúrbios relacionados a TNF-<244>, doenças virais (incluindo hepatite C), disfunção erétil e distúrbios proliferativos de célula.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0428475.8A GB0428475D0 (en) | 2004-12-30 | 2004-12-30 | Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders |
| US69389905P | 2005-06-24 | 2005-06-24 | |
| PCT/EP2005/014187 WO2006069805A2 (en) | 2004-12-30 | 2005-12-29 | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0516373A true BRPI0516373A (pt) | 2008-09-02 |
Family
ID=39705000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0516373-0A BRPI0516373A (pt) | 2004-12-30 | 2005-12-29 | derivados de pirido(3,2-d)pirimidinas e uso dos mesmos |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2008526704A (pt) |
| BR (1) | BRPI0516373A (pt) |
| IL (1) | IL184131A0 (pt) |
| MX (1) | MX2007007901A (pt) |
| RU (1) | RU2007128961A (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010091996A1 (en) * | 2009-02-12 | 2010-08-19 | Merck Serono S.A. | 2-morpholino-pyrido[3,2-d]pyrimidines |
| PT2600719E (pt) * | 2010-08-05 | 2014-12-22 | Univ Temple | 8 ¿ alquilo -2 - substituído 7 ¿ oxo ¿ 7,8 ¿ diidropirido [2,3 ¿ d] pirimidina ¿ 6 ¿ carbonitrilos e seus usos |
| SG11201606876RA (en) * | 2015-03-04 | 2016-10-28 | Gilead Sciences Inc | Toll like receptor modulator compounds |
-
2005
- 2005-12-29 RU RU2007128961/04A patent/RU2007128961A/ru not_active Application Discontinuation
- 2005-12-29 JP JP2007548769A patent/JP2008526704A/ja not_active Withdrawn
- 2005-12-29 MX MX2007007901A patent/MX2007007901A/es not_active Application Discontinuation
- 2005-12-29 BR BRPI0516373-0A patent/BRPI0516373A/pt not_active IP Right Cessation
-
2007
- 2007-06-21 IL IL184131A patent/IL184131A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007128961A (ru) | 2009-02-10 |
| MX2007007901A (es) | 2007-11-07 |
| JP2008526704A (ja) | 2008-07-24 |
| IL184131A0 (en) | 2007-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2006069805A3 (en) | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment | |
| WO2009003669A3 (en) | Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment | |
| PL1673092T3 (pl) | Pochodne pterydyny podstawione heterocyklem i ich zastosowanie w leczeniu | |
| IL185289A0 (en) | Substituted pyrido (2,3-d) pyrimidine derivatives useful as medicines for the treatment of autoimmune disorders | |
| WO2008009076A3 (en) | Substituted pyrido(3,2-d)pyrimidines and pharmaceutical compositions for treating viral infections | |
| NO20082069L (no) | 2-Amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner | |
| PT1236726E (pt) | Derivados de triazaespiro[5.5]undecano e farmacos que os contem como ingrediente activo | |
| EA201001188A1 (ru) | Связанные мостиковой связью бициклические гетероциклические или спиробициклические гетероциклические производные пиразоло[1,5-a]пиримидинов, способы их получения и их применения | |
| ATE424402T1 (de) | Imidazopyridinverbindungen | |
| GB0102687D0 (en) | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them | |
| NO20082511L (no) | Nye pyridopyraziner og deres anvendelse som kinasemodulatorer | |
| DK1812440T3 (da) | Pyrazolo[1,5-a]pyrimidiner, der kan anvendes som inhibistorer af proteinkinaser | |
| BRPI0418112A (pt) | inibidores de p-38 quinase bicìclico heterocìclicos | |
| TN2015000285A1 (en) | Therapeutically active pyrazolo-pyrimidine derivatives | |
| WO2005121145A3 (en) | Octahydro-pyrrolo[3,4-c] derivatives and their use as antiviral compounds | |
| BRPI0507065A (pt) | derivados de quinolina e seu uso como inibidores micobacterianos | |
| BR0013281A (pt) | Derivados de arilmetil-carbonilamino-tiazol, processo para sua preparação e seu uso como agentes antitumorais | |
| ATE502036T1 (de) | Als inhibitoren von beta-sekretase (bace) geeignete 2-amino-3,4-dihydropyridoä3,4- düpyrimidinderivate | |
| ATE376421T1 (de) | Immunosuppressive wirkungen von pteridinderivativen | |
| NO20091579L (no) | Nye 5,7-disubstituerte [1,3]tiazolo[4,5-d]pyrimidin-2(3H)-onderivater og deres anvendelse i terapi | |
| TW200505448A (en) | 5-hydroxyindoles with n-oxide groups and the use thereof as therapeutic agents | |
| ATE223412T1 (de) | Antikonvulsiv und antiallergisch/antiasthmatisch wirkende pyrazolo(3,4-d)pyrimidine | |
| TN2010000388A1 (fr) | DERIVES HETEROCYCLIQUES BICYCLIQUES PONTES OU DERIVES HETEROCYCLIQUE SPIRO-BICYCLIQUES DE PYRAZOLO [1,5-a] PYRIMIDINES, PROCEDES POUR LEUR PREPARATION ET LEURS UTILISATIONS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |