NO20082069L - 2-Amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner - Google Patents

2-Amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner

Info

Publication number
NO20082069L
NO20082069L NO20082069A NO20082069A NO20082069L NO 20082069 L NO20082069 L NO 20082069L NO 20082069 A NO20082069 A NO 20082069A NO 20082069 A NO20082069 A NO 20082069A NO 20082069 L NO20082069 L NO 20082069L
Authority
NO
Norway
Prior art keywords
pyrido
dihydro
amino
pyrimidin
compounds
Prior art date
Application number
NO20082069A
Other languages
English (en)
Other versions
NO342258B1 (no
Inventor
Daniel J Poon
Teresa E Pick
Christopher Mcbride
Paul A Renhowe
Timothy D Machajewski
Cynthia M Shafer
William Antonios-Mccrea
Brandon M Doughan
Barry H Levine
Yi Xia
Maureen Mckenna
X Michael Wang
Kris Mendenhall
Yasheen Zhou
Baoqing Gong
Dan Gu
John Dolan
John Tulinsky
Kristin Brinner
Zhenhai Gao
Original Assignee
Uslin Xiaodong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uslin Xiaodong filed Critical Uslin Xiaodong
Publication of NO20082069L publication Critical patent/NO20082069L/no
Publication of NO342258B1 publication Critical patent/NO342258B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)

Abstract

Det beskrives 2-arnino-7,8-dihydro-6H-pyrido[4,3-d]pyrirnidin-5-on forbindelser, deres stereoisomerer, tautomerer, farmasøytisk akseptable salter og prodrugs derav; preparater som inkluderer en farmasøytisk akseptabel bærer og en eller flere av 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-on forbindelsene, enten alene eller i kombinasjon med minst et ytterligere terapeutisk middel. Det beskrives videre metoder for anvendelse av 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-on forbindelser, enten alene eller i kombinasjon med minst et ytterligere terapeutisk middel, for profylakse eller behandling av cellulære proliferative, virale, autoimmune, kardiovaskulære og sentralnervesystem sykdommer.
NO20082069A 2005-09-30 2008-04-30 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike NO342258B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72279605P 2005-09-30 2005-09-30
US83688606P 2006-08-09 2006-08-09
PCT/US2006/038181 WO2007041362A1 (en) 2005-09-30 2006-09-28 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Publications (2)

Publication Number Publication Date
NO20082069L true NO20082069L (no) 2008-06-09
NO342258B1 NO342258B1 (no) 2018-04-30

Family

ID=37661234

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082069A NO342258B1 (no) 2005-09-30 2008-04-30 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike

Country Status (31)

Country Link
US (2) US7671059B2 (no)
EP (1) EP1928875B1 (no)
JP (2) JP5036002B2 (no)
KR (1) KR101311757B1 (no)
AR (1) AR058072A1 (no)
AT (1) ATE514694T1 (no)
AU (1) AU2006297124B2 (no)
BR (1) BRPI0616701A2 (no)
CA (1) CA2624253C (no)
CR (1) CR9846A (no)
CY (1) CY1112028T1 (no)
DK (1) DK1928875T3 (no)
EA (1) EA016152B1 (no)
EC (1) ECSP088324A (no)
GE (1) GEP20115231B (no)
HR (1) HRP20110655T1 (no)
IL (1) IL190446A0 (no)
JO (1) JO2783B1 (no)
MA (1) MA29885B1 (no)
ME (1) ME01952B (no)
MY (1) MY143604A (no)
NO (1) NO342258B1 (no)
NZ (1) NZ566914A (no)
PE (1) PE20070621A1 (no)
PL (1) PL1928875T3 (no)
PT (1) PT1928875E (no)
RS (1) RS51795B (no)
SM (1) SMP200800029B (no)
TN (1) TNSN08143A1 (no)
TW (1) TWI373471B (no)
WO (1) WO2007041362A1 (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN101225083A (zh) * 2007-01-16 2008-07-23 北京摩力克科技有限公司 四氢喹唑啉酮类化合物及其用于制备治疗和预防病毒性疾病的药物的用途
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
US8071766B2 (en) 2008-02-01 2011-12-06 Takeda Pharmaceutical Company Limited HSP90 inhibitors
US8759010B2 (en) 2008-09-26 2014-06-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Host cell kinases as targets for antiviral therapies against HCV infection
ES2621141T3 (es) * 2008-11-28 2017-07-03 Novartis Ag Combinación farmacéutica que comprende un inhibidor de Hsp 90 y un inhibidor de mTOR
MX2011005664A (es) * 2008-11-28 2011-06-16 Novartis Ag Inhibidores de hsp90 para tratamiento terapeutico.
ES2573295T3 (es) * 2008-11-28 2016-06-07 Novartis Ag Combinaciones farmacéuticas que comprenden un inhibidor de Hsp90 derivado de isoxazol y el inhibidor de HER2 trastuzumab
AR075180A1 (es) * 2009-01-29 2011-03-16 Novartis Ag Formulaciones orales solidas de una pirido-pirimidinona
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
MX2012004846A (es) * 2009-10-29 2012-10-05 Genosco Inhibidores de cinasa.
WO2012104823A2 (en) 2011-02-04 2012-08-09 Novartis Ag Pyridopyrimidinone compounds in the treatment of neurodegenerative diseases
CA2851383A1 (en) 2011-10-14 2013-04-18 Xizhong Huang 2 - carboxamide cycloamino urea derivatives in combination with hsp90 inhibitors for the treatment of proliferative diseases
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
CN103664938A (zh) * 2012-09-12 2014-03-26 山东亨利医药科技有限责任公司 含有嘧啶并环的syk抑制剂
KR20150081344A (ko) 2012-11-07 2015-07-13 노파르티스 아게 조합 요법
US9677907B2 (en) * 2013-03-14 2017-06-13 Itron Inc Intelligent receptacle
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
DK3053578T3 (da) 2013-09-30 2021-02-01 Taiho Pharmaceutical Co Ltd Kombinationscancerterapi ved hjælp af azabicycloforbindelse
CN106795154B (zh) * 2014-09-02 2019-07-05 皮埃尔法布雷医药公司 用于治疗癌症的异喹啉酮衍生物
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR101653560B1 (ko) * 2016-02-02 2016-09-12 한국화학연구원 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 인플루엔자 바이러스 감염으로 인한 질환의 예방 또는 치료용 약학적 조성물
RU2629599C1 (ru) * 2016-09-28 2017-08-30 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ химиолучевого лечения опухолей прямой кишки и анального канала
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
WO2021261562A1 (ja) * 2020-06-26 2021-12-30 日本農薬株式会社 アリールテトラヒドロピリジン誘導体又はその塩類及び該化合物を含有する殺虫剤並びにその使用方法
JP7756374B2 (ja) * 2021-03-08 2025-10-20 曁南大学 ピリドピリミジン系化合物及びその使用
WO2026027375A1 (de) 2024-07-29 2026-02-05 Bayer Aktiengesellschaft Hydroxy-dihydropyridinon carboxamide als schädlingsbekämpfungsmittel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6165873A (ja) 1984-09-07 1986-04-04 Mitsui Petrochem Ind Ltd ２−ピペラジノピリミジン誘導体
CA1307786C (en) 1984-12-14 1992-09-22 Keiichi Yokoyama Quinazoline derivatives and antihypertensive preparations containing same as effective components
MA21177A1 (fr) * 1987-02-11 1988-10-01 May & Baker Ltd Diones cycliques.
HU229604B1 (en) * 2001-02-12 2014-02-28 Hoffmann La Roche 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them
DE102004018198A1 (de) 2004-04-15 2005-11-03 Merck Patent Gmbh Sulfonamide
CA2584485C (en) 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
WO2006074293A2 (en) * 2005-01-07 2006-07-13 President And Fellows Of Harvard College Bicyclic dihydropyrimidines as eg5 inhibitors
MX2007012836A (es) * 2005-04-14 2008-01-11 Novartis Vaccines & Diagnostic 2-amino-quinazolin-5-onas como inhibidores de la familia hsp90 que son utiles en el tratamiento de enfermedades de proliferacion.

Also Published As

Publication number Publication date
CY1112028T1 (el) 2015-11-04
MY143604A (en) 2011-06-15
HRP20110655T1 (hr) 2011-10-31
KR20080057318A (ko) 2008-06-24
EA200800992A1 (ru) 2008-10-30
HK1118823A1 (en) 2009-02-20
US20070123546A1 (en) 2007-05-31
JP2009510108A (ja) 2009-03-12
JP2012158611A (ja) 2012-08-23
CA2624253C (en) 2015-06-16
PT1928875E (pt) 2011-09-06
AU2006297124B2 (en) 2011-12-08
PE20070621A1 (es) 2007-09-06
US20100004237A1 (en) 2010-01-07
RS51795B (sr) 2011-12-31
ATE514694T1 (de) 2011-07-15
NZ566914A (en) 2011-09-30
GEP20115231B (en) 2011-06-10
DK1928875T3 (da) 2011-10-03
JO2783B1 (en) 2014-03-15
MA29885B1 (fr) 2008-10-03
WO2007041362A1 (en) 2007-04-12
KR101311757B1 (ko) 2013-09-26
SMAP200800029A (it) 2008-05-07
EP1928875B1 (en) 2011-06-29
BRPI0616701A2 (pt) 2011-06-28
CA2624253A1 (en) 2007-04-12
IL190446A0 (en) 2008-11-03
AU2006297124A1 (en) 2007-04-12
TNSN08143A1 (en) 2009-07-14
CR9846A (es) 2008-08-01
SMP200800029B (it) 2008-05-07
AR058072A1 (es) 2008-01-23
PL1928875T3 (pl) 2011-11-30
JP5036002B2 (ja) 2012-09-26
TWI373471B (en) 2012-10-01
ECSP088324A (es) 2008-04-28
EA016152B1 (ru) 2012-02-28
ME01952B (en) 2011-12-31
EP1928875A1 (en) 2008-06-11
NO342258B1 (no) 2018-04-30
US7671059B2 (en) 2010-03-02
TW200728304A (en) 2007-08-01

Similar Documents

Publication Publication Date Title
TNSN08143A1 (en) 2-amino-7,8-dihydro-6h-pyrido[4,3-d]pyrimidin-5-ones
NO20052805L (no) Substituerte pyrrolo-pyrazolderivater som kinase-inhibitorer
NO20072984L (no) Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for medical treatment
DK1377589T3 (da) Oxazolyl-pyrazolderivater som kinaseinhibitorer
WO2007022073A3 (en) Novel 2'-c-methyl and 4'-c-methyl nucleoside derivatives
MX2009012595A (es) Derivados de espiroindolinona.
TW200718689A (en) 2-Amino-quinazolin-5-ones
IL191160A (en) Use of pyrido [3,2- b] pyrazine-6-yl urine urine for the preparation of drugs to treat diseases caused by the enzyme pi3k inhibition.
CY1112478T1 (el) Ενωσεις κιναζολινονης ως αντικαρκινικοι παραγοντες
NO20076055L (no) Imidazo- og triazolopyridiner som inhibitorer av 11-beta-hydroksysteroid-dehydrogenase type I
WO2008067389A3 (en) Modulation of sod protein synthesis for the treatment of neurodegenerative diseases
BR112014015720A2 (pt) derivados de tieno[3,2-d]pirimidina que têm atividade inibidora de proteinas quinases
WO2010099379A8 (en) Jak kinase modulating quinazoline derivatives and methods of use thereof
NO20076054L (no) Imidiazo - og triazolopyridiner som inhibitorer av 11-beta-hydroksysteroid-dehydrogenase type I
WO2008149382A8 (en) Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application
NO20082065L (no) Nye imidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase 3 for anvendelse ved behandling av demens og neurodegenerative forstyrrelser
NO20092251L (no) Pyrrolo [2,3-B] pyridinderivater som kinasemodulatorer
WO2005070930A3 (en) Tetrahydrocarboline compounds as anticancer agents
WO2008079159A3 (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
MX2010002733A (es) Terapia de intervalo para el tratamiento de tinnitus.
WO2005084192A3 (en) Novel 2’-c-methyl nucleoside derivatives
MX356644B (es) Derivados de 2-fenilaminopirimidina como moduladores de proteina cinasa 2 rica en unidades repetitivas de leucina (lrrk2) para el tratamiento de la enfermedad de parkinson.
GEP20105095B (en) Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
WO2008045378A3 (en) Treatment of infant hyperbilirubinemia using low dosages of stannsoporfin
WO2002070515A3 (en) Chromane derivatives, process for their preparation and their use as antitumor agents

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees