BRPI0516546A - métodos para triagem de biblioteca de anticorpos - Google Patents

métodos para triagem de biblioteca de anticorpos

Info

Publication number
BRPI0516546A
BRPI0516546A BRPI0516546-6A BRPI0516546A BRPI0516546A BR PI0516546 A BRPI0516546 A BR PI0516546A BR PI0516546 A BRPI0516546 A BR PI0516546A BR PI0516546 A BRPI0516546 A BR PI0516546A
Authority
BR
Brazil
Prior art keywords
methods
library
elements
entities
target
Prior art date
Application number
BRPI0516546-6A
Other languages
English (en)
Inventor
Marike Jose Janneke Gertrud Strassar
Herald Reiersen
Original Assignee
Affitech As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affitech As filed Critical Affitech As
Publication of BRPI0516546A publication Critical patent/BRPI0516546A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Lasers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

MéTODOS PARA TRIAGEM DE BIBLIOTECA DE ANTICORPOS. A presente invenção refere-se a um método aperfeiçoado para a triagem de uma biblioteca de moléculas para identificar ou selecionar um ou mais de seus elementos que sejam candidatos a parceiros de ligação para uma ou mais entidades alvo, compreendendo: (a) o contato de uma biblioteca de expressão com uma ou mais entidades alvo; (b) a submissão das ditas entidades alvo a pelo menos uma etapa de lavagem; (c) a separação das entidades alvo que tenham ficado ligadas a um ou mais elementos da biblioteca de expressão de elementos não ligados da biblioteca de expressão porseparação através de uma fase orgânica, separando, dessa forma, candidatos a parceiros de ligação para as ditas entidades alvo de outros elementos da biblioteca.
BRPI0516546-6A 2004-10-08 2005-10-07 métodos para triagem de biblioteca de anticorpos BRPI0516546A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0422431.7A GB0422431D0 (en) 2004-10-08 2004-10-08 Method
PCT/GB2005/003866 WO2006038022A1 (en) 2004-10-08 2005-10-07 Methods for antibody library screening

Publications (1)

Publication Number Publication Date
BRPI0516546A true BRPI0516546A (pt) 2008-09-09

Family

ID=33443626

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516546-6A BRPI0516546A (pt) 2004-10-08 2005-10-07 métodos para triagem de biblioteca de anticorpos

Country Status (21)

Country Link
US (1) US20090081190A1 (pt)
EP (1) EP1800133B1 (pt)
JP (1) JP4564062B2 (pt)
CN (1) CN101052879B (pt)
AT (1) ATE495446T1 (pt)
AU (1) AU2005291012B2 (pt)
BR (1) BRPI0516546A (pt)
CA (1) CA2580080C (pt)
DE (1) DE602005025901D1 (pt)
DK (1) DK1800133T3 (pt)
ES (1) ES2359724T3 (pt)
GB (1) GB0422431D0 (pt)
HR (1) HRP20110234T1 (pt)
IL (1) IL181927A (pt)
NO (1) NO20071618L (pt)
NZ (1) NZ554076A (pt)
PL (1) PL1800133T3 (pt)
RU (1) RU2402777C2 (pt)
SI (1) SI1800133T1 (pt)
WO (1) WO2006038022A1 (pt)
ZA (1) ZA200702527B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009032949A2 (en) * 2007-09-04 2009-03-12 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection
US9079942B2 (en) * 2009-02-09 2015-07-14 Epitomics, Inc. CDR-anchored amplification method
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
US8293483B2 (en) * 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
US9340606B2 (en) 2010-10-26 2016-05-17 Arizona Board Of Regents On Behalf Of Arizona State University Immunization with amyloid-beta oligomers
GB201116364D0 (en) * 2011-09-22 2011-11-02 Bioinvent Int Ab Screening methods and uses thereof
ES3011307T3 (en) * 2012-02-23 2025-04-07 Juno Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
EP2786147B1 (en) * 2012-12-04 2017-02-01 Scinopharm Taiwan Ltd. Method for selecting a pool of molecules
RU2560699C2 (ru) * 2013-08-02 2015-08-20 федеральное государственное автономное образовательное учреждение высшего профессионального образования "Национальный исследовательский ядерный университет МИФИ" (НИЯУ МИФИ) Способ создания наноразмерной диагностической метки на основе конъюгатов наночастиц и однодоменных антител
GB201420852D0 (en) * 2014-11-24 2015-01-07 Genevillage Kft Method
RU2618872C1 (ru) * 2015-12-09 2017-05-11 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Способ направленного истощения олигонуклеотидных библиотек для снижения неспецифической адсорбции при твердофазной селекции аптамеров на основе нуклеиновых кислот
US10557216B2 (en) * 2018-04-24 2020-02-11 Inscripta, Inc. Automated instrumentation for production of T-cell receptor peptide libraries
BR112021021261A2 (pt) 2019-04-22 2021-12-21 Ddbio Co Ltd Shang Hai Método para produzir uma biblioteca de fagos que exibe um anticorpo ou fragmento de anticorpo, biblioteca de fagos e método para selecionar um anticorpo ou fragmento de anticorpo
KR102301987B1 (ko) * 2019-11-14 2021-09-13 연세대학교 산학협력단 항체 선별 방법, 박테리아 오염 진단 방법 및 박테리아 오염 진단 키트

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5492807A (en) * 1993-11-19 1996-02-20 Santi; Daniel V. Method of obtaining diagnostic reagents, assays and therapeutics based on clinical manifestations of a disease
US6255455B1 (en) * 1996-10-11 2001-07-03 The Trustees Of The University Of Pennsylvania Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
TW585921B (en) * 1997-07-10 2004-05-01 Res Dev Foundation Species specific monoclonal antibodies and phage displayed Fab and scFV fragments for fragments for targeted destruction of imported fire ants
RU2184780C2 (ru) * 2000-08-09 2002-07-10 Государственный научный центр вирусологии и биотехнологии "Вектор" ПЕПТИД-ИМИТАТОР ЭПИТОПА БЕЛКА gp120 ВИЧ-1
US6235686B1 (en) * 2000-08-16 2001-05-22 R.T. Vanderbilt Company, Inc. Lubricating compositions containing aromatized 1,2-dihydro-2,2,4-trimethylquinoline polymers
EP2028187A1 (en) * 2000-09-08 2009-02-25 Board Of Regents, The University Of Texas System Human and mouse targeting peptides identified by phage display
US7420030B2 (en) * 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US20040170955A1 (en) * 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US20040048243A1 (en) * 2001-09-07 2004-03-11 Wadih Arap Methods and compositions for in vitro targeting

Also Published As

Publication number Publication date
HK1105450A1 (en) 2008-02-15
CA2580080A1 (en) 2006-04-13
DK1800133T3 (da) 2011-03-28
NO20071618L (no) 2007-06-27
DE602005025901D1 (de) 2011-02-24
JP2008516220A (ja) 2008-05-15
HRP20110234T1 (hr) 2011-05-31
RU2402777C2 (ru) 2010-10-27
ATE495446T1 (de) 2011-01-15
GB0422431D0 (en) 2004-11-10
EP1800133A1 (en) 2007-06-27
CN101052879B (zh) 2012-07-25
JP4564062B2 (ja) 2010-10-20
CA2580080C (en) 2012-09-18
ES2359724T3 (es) 2011-05-26
WO2006038022A1 (en) 2006-04-13
NZ554076A (en) 2009-12-24
AU2005291012A1 (en) 2006-04-13
RU2007117144A (ru) 2008-11-20
IL181927A (en) 2011-09-27
SI1800133T1 (sl) 2011-06-30
IL181927A0 (en) 2007-07-04
ZA200702527B (en) 2008-11-26
AU2005291012B2 (en) 2011-04-14
EP1800133B1 (en) 2011-01-12
CN101052879A (zh) 2007-10-10
US20090081190A1 (en) 2009-03-26
PL1800133T3 (pl) 2011-06-30

Similar Documents

Publication Publication Date Title
NO20071618L (no) Fremgangsmate for screening av antistoffbibliotek
Tian et al. Enhanced top-down characterization of histone post-translational modifications
Jedrychowski et al. Evaluation of HCD-and CID-type fragmentation within their respective detection platforms for murine phosphoproteomics
Bonet-Costa et al. Combined bottom-up and top-down mass spectrometry analyses of the pattern of post-translational modifications of Drosophila melanogaster linker histone H1
BR112013025629A2 (pt) padrão quantitativo para espectrometria de massa de proteínas
NZ584684A (en) A method for characterization of a recombinant polyclonal protein
BRPI0820156B8 (pt) processo para purificação de uma biomolécula alvo
ECSP088081A (es) Detección de un antigeno diana independientemente de la presencia o ausencia de un anticuerpo terapéutico correspondiente
Mladic et al. Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS
BR112019024602A2 (pt) ensaio para doença associada à célula de plasma
Nakayasu et al. A method to determine lysine acetylation stoichiometries
Battistini et al. Proteomic analysis by mass spectrometry of postmortem muscle protein degradation for PMI estimation: A pilot study
Echterbille et al. Ion mobility mass spectrometry as a potential tool to assign disulfide bonds arrangements in peptides with multiple disulfide bridges
Aibara et al. Selective, sensitive and comprehensive detection of immune complex antigens by immune complexome analysis with papain-digestion and elution
BR112021016348A2 (pt) Método de produção de uma proteína de fusão ligante-toxina em uma célula de planta ou em uma planta inteira
Sivadasan et al. Data from human salivary proteome–a resource of potential biomarkers for oral cancer
Luczak et al. Optimization of plasma sample pretreatment for quantitative analysis using iTRAQ labeling and LC-MALDI-TOF/TOF
Bailo et al. Mass spectrometry proteomic profiling of postmortem human muscle degradation for PMI estimation
Chick et al. An ultra-tolerant database search reveals that a myriad of modified peptides contributes to unassigned spectra in shotgun proteomics
WO2009064006A1 (ja) γ-セクレターゼの新規基質EphA7を利用したスクリーニング方法
Boatto et al. Determination of four thiophenethylamine designer drugs (2C-T-series) in human plasma by capillary electrophoresis with mass spectrometry detection
Nieddu et al. Determination of 4-alkyl 2, 5 dimethoxy-amphetamine derivatives by capillary electrophoresis with mass spectrometry detection from urine samples
EP1824498A4 (en) METHOD AND COMPOSITIONS FOR TREATING PROLIFERATIVE CELL DISEASES
Pai et al. Direct glycan structure determination of intact N-linked glycopeptides by low-energy collision-induced dissociation tandem mass spectrometry and predicted spectral library searching
WO2008081331A3 (en) Enhancing the level of antibody expression by framework re-engineering

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: REF. A RPI NO 2150 DE 20/03/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements