BRPI0517840A - inibidores de lipase - Google Patents

inibidores de lipase

Info

Publication number
BRPI0517840A
BRPI0517840A BRPI0517840-1A BRPI0517840A BRPI0517840A BR PI0517840 A BRPI0517840 A BR PI0517840A BR PI0517840 A BRPI0517840 A BR PI0517840A BR PI0517840 A BRPI0517840 A BR PI0517840A
Authority
BR
Brazil
Prior art keywords
inhibitors
lipase inhibitors
lipase
prototype
electrolytic
Prior art date
Application number
BRPI0517840-1A
Other languages
English (en)
Inventor
Daniel Philip O'connell
Hung-Sen Lai
William W Bachovchin
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of BRPI0517840A publication Critical patent/BRPI0517840A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

INIBIDORES DE LIPASE. A presente invenção se refere a inibidores de lipases, tais como inibidores de lipase endotelial, bem como a composições farmacêuticas dos mesmos e a métodos para uso de tais inibidores, O protótipo desses inibidores tem uma parte lipofílica e um sítio eletrolítico.
BRPI0517840-1A 2004-11-12 2005-11-14 inibidores de lipase BRPI0517840A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62747604P 2004-11-12 2004-11-12
PCT/US2005/041022 WO2006053250A2 (en) 2004-11-12 2005-11-14 Lipase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0517840A true BRPI0517840A (pt) 2008-10-21

Family

ID=36337276

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517840-1A BRPI0517840A (pt) 2004-11-12 2005-11-14 inibidores de lipase

Country Status (11)

Country Link
US (2) US20090209492A1 (pt)
EP (1) EP1824861A2 (pt)
JP (1) JP2008519853A (pt)
KR (1) KR20070086076A (pt)
CN (1) CN101356179A (pt)
AU (1) AU2005304318A1 (pt)
BR (1) BRPI0517840A (pt)
CA (1) CA2586479A1 (pt)
IL (1) IL183129A0 (pt)
NO (1) NO20073011L (pt)
WO (1) WO2006053250A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP2529793B1 (en) * 2007-06-08 2016-08-10 Georgia State University Research Foundation, Inc. Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria
CA2721060A1 (en) 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US8957219B2 (en) 2008-10-17 2015-02-17 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on endothelial lipase
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118155A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
ATE555721T1 (de) * 2009-04-23 2012-05-15 Hoffmann La Roche Verfahren und gerät zur ermittlung von empfehlungen für wirkstoffdosierungen anhand von messserien zumindest eines physiologischen parameters eines patienten
KR20120123325A (ko) 2009-12-15 2012-11-08 시오노기세야쿠 가부시키가이샤 혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
RU2015143910A (ru) 2010-02-03 2018-12-28 Инфинити Фармасьютикалз, Инк. Ингибиторы амид-гидролазы жирных кислот
EP2575823A1 (en) * 2010-05-31 2013-04-10 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. 3-substituted vinylboronates and uses thereof
CN105806967B (zh) * 2014-12-31 2018-02-06 广州朗圣药业有限公司 依折麦布关键中间体4‑[[(4‑氟苯基)亚胺]甲基]‑苯酚的分析方法
CN105572252A (zh) * 2015-12-18 2016-05-11 武汉武药科技有限公司 一种分析/分离依折麦布(r,r,s)型的光学异构体的方法
EP3765006A4 (en) * 2018-03-13 2022-02-23 Merck Sharp & Dohme Corp. ARGINASE INHIBITORS AND METHODS OF USE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA58494C2 (uk) * 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
JP3456511B2 (ja) * 1997-01-27 2003-10-14 昭和電工株式会社 陰イオンの分析法及び陰イオン分析セット
JPH10210999A (ja) * 1997-01-29 1998-08-11 Eiken Chem Co Ltd エステル加水分解酵素活性の阻害方法
TW458977B (en) * 1997-04-16 2001-10-11 Abbott Lab 6,7-disubstituted-4-aminopyrido[2,3-D] pyrimidine compounds
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity

Also Published As

Publication number Publication date
WO2006053250A2 (en) 2006-05-18
WO2006053250A3 (en) 2008-07-10
AU2005304318A1 (en) 2006-05-18
KR20070086076A (ko) 2007-08-27
CN101356179A (zh) 2009-01-28
JP2008519853A (ja) 2008-06-12
US20090209492A1 (en) 2009-08-20
IL183129A0 (en) 2008-04-13
CA2586479A1 (en) 2006-05-18
NO20073011L (no) 2007-08-08
US20120101062A1 (en) 2012-04-26
EP1824861A2 (en) 2007-08-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.