BRPI0517908A - cepa mutante de e. coli, e, método para produzir uma substáncia útil - Google Patents

cepa mutante de e. coli, e, método para produzir uma substáncia útil

Info

Publication number
BRPI0517908A
BRPI0517908A BRPI0517908-4A BRPI0517908A BRPI0517908A BR PI0517908 A BRPI0517908 A BR PI0517908A BR PI0517908 A BRPI0517908 A BR PI0517908A BR PI0517908 A BRPI0517908 A BR PI0517908A
Authority
BR
Brazil
Prior art keywords
useful substance
coli
producing
mutant
strain
Prior art date
Application number
BRPI0517908-4A
Other languages
English (en)
Inventor
Hiroshi Mizoguchi
Kiyotaka Hara
Hideo Mori
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of BRPI0517908A publication Critical patent/BRPI0517908A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

CEPA MUTANTE DE E. COLI, E, METODO PARA PRODUZIR UMA SUBSTáNCIA úTIL. De acordo com a presente invenção, cepa mutante de E. coli tendo DNA cromossómico que é pelo menos 470 kbp mais curto do que o de uma cepa de E. coli de tipo selvagem demonstra uma tal propriedade que o número de células após um determinado período de cultura é maior do que o de uma cepa de tipo selvagem. Assim, por cultivo da cepa mutante em um meio, de modo a gerar e acumular uma substância útil na cultura, uma substância útil, como proteínas, peptideos, aminoácidos, ácidos nucleicos, vitaminas, sacarídeos, ácidos orgânicos e lipideos, pode ser produzida de modo eficiente.
BRPI0517908-4A 2004-11-26 2005-11-25 cepa mutante de e. coli, e, método para produzir uma substáncia útil BRPI0517908A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004341706 2004-11-26
JP2005203965 2005-07-13
PCT/JP2005/021691 WO2006057341A1 (ja) 2004-11-26 2005-11-25 工業的に有用な微生物

Publications (1)

Publication Number Publication Date
BRPI0517908A true BRPI0517908A (pt) 2008-10-14

Family

ID=36498074

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517908-4A BRPI0517908A (pt) 2004-11-26 2005-11-25 cepa mutante de e. coli, e, método para produzir uma substáncia útil

Country Status (7)

Country Link
US (1) US20080009041A1 (pt)
EP (1) EP1829965A4 (pt)
JP (1) JPWO2006057341A1 (pt)
KR (1) KR20070086634A (pt)
AU (1) AU2005308101A1 (pt)
BR (1) BRPI0517908A (pt)
WO (1) WO2006057341A1 (pt)

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RU2392322C2 (ru) * 2007-08-14 2010-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) СПОСОБ ПОЛУЧЕНИЯ L-ТРЕОНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia, В КОТОРОЙ ИНАКТИВИРОВАН ГЕН yahN
JP5217780B2 (ja) * 2008-02-08 2013-06-19 味の素株式会社 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
EP2298880A4 (en) * 2008-03-18 2012-02-08 Kyowa Hakko Kirin Co Ltd INDUSTRIALLY USEFUL MICROORGANISM
JP5488467B2 (ja) * 2008-09-05 2014-05-14 味の素株式会社 Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
JP2012029565A (ja) * 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
RU2008148283A (ru) 2008-12-09 2010-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА ENTEROBACTERIACEAE, В КОТОРОЙ ОСЛАБЛЕНА ЭКСПРЕССИЯ ГЕНА artI
US20100261168A1 (en) * 2009-04-08 2010-10-14 Tufts University Screening for Environmental DNAs Encoding Enzymes for Synthesizing Terpenoid-Based Therapeutic Compounds Using Genetically Modified E. Coli Strains
CA2768794C (en) 2009-07-22 2018-09-18 E. I. Du Pont De Nemours And Company Sequences and their use for detection and characterization of e. coli o157:h7
US9017976B2 (en) 2009-11-18 2015-04-28 Myriant Corporation Engineering microbes for efficient production of chemicals
KR101261147B1 (ko) * 2011-01-18 2013-05-06 씨제이제일제당 (주) Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
WO2012103263A2 (en) * 2011-01-25 2012-08-02 Finley Kenneth R Compositions and methods for malate and fumarate production
EP2668281A4 (en) 2011-01-25 2015-08-26 Cargill Inc COMPOSITIONS AND METHODS OF SUCCINATE MANUFACTURE
WO2012135389A2 (en) 2011-03-28 2012-10-04 The Regents Of The University Of California Host cells and methods for oxidizing aromatic amino acids
EP3901248A1 (en) 2012-07-25 2021-10-27 Cargill, Incorporated Yeast cells having reductive tca pathway from pyruvate to succinate and overexpressing an exogenous nad(p)+ transhydrogenase enzyme
EP2730655A1 (de) 2012-11-12 2014-05-14 Evonik Industries AG Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen
WO2015073720A1 (en) * 2013-11-14 2015-05-21 Scarab Genomics, Llc Bacteria with improved metabolic capacity
DK3089991T3 (da) * 2013-12-31 2019-12-02 Danisco Us Inc Forbedret proteinekspression
KR101608734B1 (ko) 2014-03-21 2016-04-04 씨제이제일제당 주식회사 L-아미노산을 생산하는 미생물 및 이를 이용하여 l-아미노산을 생산하는 방법
KR101599802B1 (ko) * 2014-05-23 2016-03-04 씨제이제일제당 주식회사 세포내 에너지 수준이 향상된 미생물 및 이를 이용하여 l-아미노산을 생산하는 방법
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN108913706B (zh) * 2018-07-10 2021-04-09 郑州轻工业学院 一种枯草芽孢杆菌甘油激酶突变基因glpK及其应用
CN109554325B (zh) * 2019-01-09 2020-11-03 江南大学 一种可高产酪氨酸的大肠杆菌工程菌及其应用
KR102259933B1 (ko) * 2019-05-16 2021-06-02 국방과학연구소 포자 표면발현을 이용한 탄저 포자 백신의 제조방법 및 탄저 포자 백신
CN110373438B (zh) * 2019-07-31 2021-05-04 江南大学 一种提高γ-氨基丁酸产量的方法
CN110551672B (zh) * 2019-09-30 2023-05-23 中国科学院成都生物研究所 高产反式-4-羟基-l-脯氨酸的大肠杆菌菌株及其构建方法
CN111019877B (zh) * 2019-12-31 2022-04-19 浙江工业大学 一种产l-半胱氨酸的基因工程菌、构建方法及应用
EP4172310A1 (de) * 2020-06-26 2023-05-03 Wacker Chemie AG Verbesserte cystein produzierende stämme
US12037621B2 (en) * 2021-09-15 2024-07-16 Archer-Daniels-Midland Company Threonine production strain having attenuated expression of the yafV gene
US20260130952A1 (en) * 2021-10-27 2026-05-14 University Of Cincinnati Engineered bacteria and methods of use in tumor remodeling
CN114015635B (zh) * 2021-11-23 2023-08-08 徐州医科大学 一种大肠杆菌BW25113菌株yjgW基因敲除突变株及其应用
KR102688937B1 (ko) * 2021-12-31 2024-07-29 씨제이제일제당 주식회사 O-포스포세린 생산 미생물 및 이를 이용한 o-포스포세린 또는 l-시스테인 생산 방법
CN116200322B (zh) * 2023-02-21 2026-01-02 江南大学 一种生产l-酪氨酸的重组大肠杆菌及应用
KR102987294B1 (ko) * 2023-03-31 2026-07-07 씨제이제일제당 주식회사 망간 유입 단백질의 활성이 조절된 재조합 미생물 및 이를 이용한 o-포스포세린, 시스테인 및 이의 유도체의 생산방법
KR102985066B1 (ko) * 2023-03-31 2026-07-02 씨제이제일제당 주식회사 알킬하이드로퍼옥사이드 환원효소의 발현이 조절된 재조합 미생물 및 이를 이용한 o-포스포세린, 시스테인 및 이의 유도체의 생산방법
CN116555152B (zh) * 2023-07-04 2023-10-20 黑龙江伊品生物科技有限公司 大肠杆菌及其构建方法与在生产l-缬氨酸中的应用
CN120796156A (zh) * 2024-04-10 2025-10-17 杭州明德生物医药技术有限公司 一种新型大肠杆菌宿主细胞、其构建方法和应用
CN119776248B (zh) * 2024-12-31 2026-06-19 江苏华澄生物科技有限公司 一种合成吲哚乙酸酯的重组大肠杆菌构建及染色应用

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JP4376038B2 (ja) * 2003-04-09 2009-12-02 協和発酵キリン株式会社 生育が向上した微生物菌株

Also Published As

Publication number Publication date
US20080009041A1 (en) 2008-01-10
KR20070086634A (ko) 2007-08-27
EP1829965A4 (en) 2008-09-24
AU2005308101A1 (en) 2006-06-01
EP1829965A1 (en) 2007-09-05
WO2006057341A1 (ja) 2006-06-01
JPWO2006057341A1 (ja) 2008-06-05

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Legal Events

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B25D Requested change of name of applicant approved

Owner name: KYOWA HAKKO KIRIN CO., LTD. (JP)

Free format text: NOME ALTERADO DE: KYOWA HAKKO KOGYO CO., LTD.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2209 DE 07/05/2013.