BRPI0400577A - Processo para produzir um l-aminoácido - Google Patents
Processo para produzir um l-aminoácidoInfo
- Publication number
- BRPI0400577A BRPI0400577A BR0400577-5A BRPI0400577A BRPI0400577A BR PI0400577 A BRPI0400577 A BR PI0400577A BR PI0400577 A BRPI0400577 A BR PI0400577A BR PI0400577 A BRPI0400577 A BR PI0400577A
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- culture medium
- making
- producing
- bacterium
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000008575 L-amino acids Chemical class 0.000 abstract 3
- 239000001963 growth medium Substances 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 abstract 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 2
- 241000588722 Escherichia Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
- 229930182844 L-isoleucine Natural products 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229960002885 histidine Drugs 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 pentose sugars Chemical class 0.000 abstract 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 229960002898 threonine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/227—Tryptophan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"PROCESSO PARA PRODUZIR UM L-AMINOáCIDO". é apresentado um processo para a produção de um Laminoácido, como L-isoleucina, L-histidina, L-treonina e L-triptofano, utilizando uma bactéria que pertence ao gênero Escherichia, que compreende o cultivo da bactéria produtora do L-aminoácido em um meio de cultura e a extração do L- aminoácido do meio de cultura, onde o meio de cultura contém uma mistura de açúcares de glucose e pentose, como arabinose e xilose.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2003105269/13A RU2273666C2 (ru) | 2003-02-26 | 2003-02-26 | Способ получения l-аминокислот методом ферментации смеси глюкозы и пентоз |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0400577A true BRPI0400577A (pt) | 2004-12-07 |
| BRPI0400577B1 BRPI0400577B1 (pt) | 2014-12-23 |
Family
ID=33129392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0400577-5A BRPI0400577B1 (pt) | 2003-02-26 | 2004-02-20 | Processo para produzir um l-aminoácido |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20040229321A1 (pt) |
| JP (1) | JP2004254694A (pt) |
| BR (1) | BRPI0400577B1 (pt) |
| RU (1) | RU2273666C2 (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976843A (en) * | 1992-04-22 | 1999-11-02 | Ajinomoto Co., Inc. | Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine |
| RU2212447C2 (ru) * | 2000-04-26 | 2003-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты) |
| RU2244007C2 (ru) * | 2002-02-27 | 2005-01-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-треонина, штамм escherichia coli - продуцент треонина (варианты) |
| RU2245919C2 (ru) * | 2002-09-06 | 2005-02-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислоты, штамм escherichia coli tdh7δ mlc::cat/pprt614-продуцент l-треонина |
| RU2273666C2 (ru) * | 2003-02-26 | 2006-04-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот методом ферментации смеси глюкозы и пентоз |
| RU2276687C2 (ru) * | 2003-07-16 | 2006-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Бактерия, принадлежащая к роду escherichia, - продуцент l-гистидина и способ получения l-гистидина |
| RU2276688C2 (ru) * | 2003-08-29 | 2006-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | БАКТЕРИЯ, ПРИНАДЛЕЖАЩАЯ К РОДУ Escherichia,- ПРОДУЦЕНТ L-ГИСТИДИНА И СПОСОБ ПОЛУЧЕНИЯ L-ГИСТИДИНА |
| US20050176033A1 (en) * | 2003-11-10 | 2005-08-11 | Klyachko Elena V. | Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine |
| RU2275424C2 (ru) * | 2003-12-05 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia |
| US20050214913A1 (en) * | 2004-03-16 | 2005-09-29 | Marchenko Aleksey N | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes |
| US8003367B2 (en) * | 2004-03-16 | 2011-08-23 | Ajinomoto Co., Inc. | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes |
| WO2005095627A2 (en) * | 2004-03-31 | 2005-10-13 | Ajinomoto Co., Inc. | Method for producing purine nucleosides and nucleotides by fermentation using bacterium belonging to the genus bacillus or escherichia |
| US20060008546A1 (en) * | 2004-05-28 | 2006-01-12 | Cargill, Incorporated | Organisms with enhanced histidine biosynthesis and their use in animal feeds |
| RU2004124226A (ru) * | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| RU2315807C2 (ru) * | 2004-09-10 | 2008-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ НОРЛЕЙЦИНА И НОРВАЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Escherichia, В КОТОРОЙ ВСЕ СИНТАЗЫ АЦЕТОГИДРОКСИКИСЛОТ ИНАКТИВИРОВАНЫ |
| US7915018B2 (en) | 2004-10-22 | 2011-03-29 | Ajinomoto Co., Inc. | Method for producing L-amino acids using bacteria of the Enterobacteriaceae family |
| RU2004130954A (ru) | 2004-10-22 | 2006-04-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae |
| RU2004137198A (ru) * | 2004-12-21 | 2006-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ СЕМЕЙСТВА Enterobacteriaceae, В КОТОРОЙ ИНАКТИВИРОВАН ГЕН yafA |
| RU2004137719A (ru) * | 2004-12-23 | 2006-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-аминокислот с использованием бактерий семейства enterobacteriaceae |
| US20070212764A1 (en) * | 2005-01-19 | 2007-09-13 | Ptitsyn Leonid R | Method for producing l-amino acids using bacterium of the enterobacteriaceae family |
| US7422880B2 (en) * | 2005-01-19 | 2008-09-09 | Ajinomoto Co., Inc. | Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having a pathway of glycogen biosynthesis disrupted |
| EP1848810A1 (en) * | 2005-02-18 | 2007-10-31 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having expression of the bola gene attenuated |
| EP1848811B1 (en) | 2005-02-18 | 2009-08-05 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
| ATE417119T1 (de) | 2005-02-18 | 2008-12-15 | Ajinomoto Kk | Verfahren zur herstellung einer nichtaromatischen l-aminosäure unter verwendung eines bakteriums der familie enterobacteriaceae mit abgeschwächter expression des csra-gens |
| EP1929027B1 (en) * | 2005-08-09 | 2009-01-14 | Ajinomoto Co., Inc. | A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE ybiV GENE |
| EP2004803A2 (en) | 2006-03-23 | 2008-12-24 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using bacterium of theenterobacteriaceae family with attenuated expression of a gene coding for small rna |
| CN101517086A (zh) | 2006-07-21 | 2009-08-26 | 希乐克公司 | 生物质转化系统 |
| JP2010263790A (ja) * | 2007-09-04 | 2010-11-25 | Ajinomoto Co Inc | アミノ酸生産微生物及びアミノ酸の製造法 |
| RU2395579C2 (ru) | 2007-12-21 | 2010-07-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia |
| WO2015093467A1 (ja) * | 2013-12-16 | 2015-06-25 | 味の素株式会社 | セルラーゼ生産微生物 |
| KR102221040B1 (ko) * | 2019-05-09 | 2021-03-03 | 씨제이제일제당 주식회사 | L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU904325A1 (ru) * | 1980-08-06 | 1990-08-23 | Всесоюзный Научно-Исследовательский Институт Генетики И Селекции Микроорганизмов | Способ получени L-треонина |
| JPS6047692A (ja) * | 1983-08-25 | 1985-03-15 | Ajinomoto Co Inc | 発酵法によるｌ−スレオニンの製造法 |
| DE3891417C5 (de) * | 1988-10-25 | 2006-01-05 | Ajinomoto Co., Inc. | Verfahren zur Veränderung eines L-Threonin produzierenden Mikroorganismus und Verwendung eines so erhaltenen Mikroorganismus zur Herstellung von L-Threonin |
| US5976843A (en) * | 1992-04-22 | 1999-11-02 | Ajinomoto Co., Inc. | Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine |
| DE4232468A1 (de) * | 1992-09-28 | 1994-03-31 | Consortium Elektrochem Ind | Mikroorganismen für die Produktion von Tryptophan und Verfahren zu ihrer Herstellung |
| US5998178A (en) * | 1994-05-30 | 1999-12-07 | Ajinomoto Co., Ltd. | L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation |
| JP3975470B2 (ja) * | 1994-05-30 | 2007-09-12 | 味の素株式会社 | 発酵法によるｌ−イソロイシンの製造法 |
| US5939295A (en) * | 1996-03-29 | 1999-08-17 | Archer Daniels Midland Company | Production of tryptophan by microorganisms |
| RU2119536C1 (ru) * | 1997-01-21 | 1998-09-27 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Штамм escherichia coli - продуцент l-гистидина |
| US6087140A (en) * | 1997-02-19 | 2000-07-11 | Wisconsin Alumni Research Foundation | Microbial production of 1,2-propanediol from sugar |
| RU2212447C2 (ru) * | 2000-04-26 | 2003-09-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Штамм escherichia coli - продуцент аминокислоты (варианты) и способ получения аминокислот (варианты) |
| US7220571B2 (en) * | 2000-09-28 | 2007-05-22 | Archer-Daniels-Midland Company | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation |
| RU2229513C2 (ru) * | 2001-11-23 | 2004-05-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот, штамм escherichia coli - продуцент l-аминокислоты (варианты) |
| RU2244007C2 (ru) * | 2002-02-27 | 2005-01-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-треонина, штамм escherichia coli - продуцент треонина (варианты) |
| RU2245919C2 (ru) * | 2002-09-06 | 2005-02-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислоты, штамм escherichia coli tdh7δ mlc::cat/pprt614-продуцент l-треонина |
| RU2273666C2 (ru) * | 2003-02-26 | 2006-04-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Способ получения l-аминокислот методом ферментации смеси глюкозы и пентоз |
| RU2276687C2 (ru) * | 2003-07-16 | 2006-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Бактерия, принадлежащая к роду escherichia, - продуцент l-гистидина и способ получения l-гистидина |
| RU2276688C2 (ru) * | 2003-08-29 | 2006-05-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | БАКТЕРИЯ, ПРИНАДЛЕЖАЩАЯ К РОДУ Escherichia,- ПРОДУЦЕНТ L-ГИСТИДИНА И СПОСОБ ПОЛУЧЕНИЯ L-ГИСТИДИНА |
| US20050176033A1 (en) * | 2003-11-10 | 2005-08-11 | Klyachko Elena V. | Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine |
| RU2275424C2 (ru) * | 2003-12-05 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-треонина с использованием бактерий, принадлежащих к роду escherichia |
| US20050181488A1 (en) * | 2004-02-12 | 2005-08-18 | Akhverdian Valery Z. | Method for producing L-threonine using bacteria belonging to the genus Escherichia |
| US20050214913A1 (en) * | 2004-03-16 | 2005-09-29 | Marchenko Aleksey N | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes |
| US8003367B2 (en) * | 2004-03-16 | 2011-08-23 | Ajinomoto Co., Inc. | Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes |
-
2003
- 2003-02-26 RU RU2003105269/13A patent/RU2273666C2/ru active
-
2004
- 2004-02-20 BR BRPI0400577-5A patent/BRPI0400577B1/pt not_active IP Right Cessation
- 2004-02-25 US US10/784,980 patent/US20040229321A1/en not_active Abandoned
- 2004-02-26 JP JP2004051056A patent/JP2004254694A/ja active Pending
-
2005
- 2005-09-08 US US11/220,669 patent/US20060035346A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0400577B1 (pt) | 2014-12-23 |
| RU2273666C2 (ru) | 2006-04-10 |
| US20060035346A1 (en) | 2006-02-16 |
| JP2004254694A (ja) | 2004-09-16 |
| US20040229321A1 (en) | 2004-11-18 |
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