BRPI0518158A - tiazolinonas de azaindol como agentes anti-cáncer - Google Patents

tiazolinonas de azaindol como agentes anti-cáncer

Info

Publication number
BRPI0518158A
BRPI0518158A BRPI0518158-5A BRPI0518158A BRPI0518158A BR PI0518158 A BRPI0518158 A BR PI0518158A BR PI0518158 A BRPI0518158 A BR PI0518158A BR PI0518158 A BRPI0518158 A BR PI0518158A
Authority
BR
Brazil
Prior art keywords
cancer agents
thiazolinones
azaindol
cdk1
azaindole
Prior art date
Application number
BRPI0518158-5A
Other languages
English (en)
Inventor
Shaoquing Chen
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0518158A publication Critical patent/BRPI0518158A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

TIAZOLINONAS DE AZAINDOL COMO AGENTES ANTI-CáNCER. A presente invenção descreve derivados de tíazolinona de azaindol da fórmula geral I que demonstram atividade antiproliferativa de CDKI e CDK2 e são úteis como agentes anti-câncer; processos para a fabricação dos referidos compostos, bem como medicamentos contendo-os.
BRPI0518158-5A 2004-10-14 2005-10-05 tiazolinonas de azaindol como agentes anti-cáncer BRPI0518158A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61867204P 2004-10-14 2004-10-14
PCT/EP2005/010702 WO2006040049A1 (en) 2004-10-14 2005-10-05 Novel azaindole thiazolinones as anti-cancer agents

Publications (1)

Publication Number Publication Date
BRPI0518158A true BRPI0518158A (pt) 2008-11-04

Family

ID=35423339

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518158-5A BRPI0518158A (pt) 2004-10-14 2005-10-05 tiazolinonas de azaindol como agentes anti-cáncer

Country Status (15)

Country Link
US (1) US7247727B2 (pt)
EP (1) EP1805175B1 (pt)
JP (1) JP2008516903A (pt)
KR (1) KR100875870B1 (pt)
CN (1) CN100569773C (pt)
AT (1) ATE388149T1 (pt)
AU (1) AU2005293831B2 (pt)
BR (1) BRPI0518158A (pt)
CA (1) CA2582986A1 (pt)
DE (1) DE602005005211T2 (pt)
ES (1) ES2301066T3 (pt)
MX (1) MX2007004273A (pt)
PL (1) PL1805175T3 (pt)
RU (1) RU2391342C2 (pt)
WO (1) WO2006040049A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7371862B2 (en) * 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
FR2907120B1 (fr) 2006-10-12 2013-01-11 Sanofi Aventis Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7
FR2926463B1 (fr) * 2008-01-22 2010-08-13 Centre Nat Rech Scient Utilisation d'inhibiteurs d'aminopeptidase ou de composes azaindole pour la prevention ou le traitement de metastases cancereuses d'origine epitheliale
US20120135989A1 (en) * 2010-06-29 2012-05-31 Crystalgenomics, Inc. Azaindole derivative
MX344474B (es) * 2011-03-31 2016-12-16 Carna Biosciences Inc Nuevos derivados de furanona.
KR101277161B1 (ko) * 2011-07-08 2013-06-20 주식회사 엠엠테크 글라스 박형화 시스템
WO2014141082A1 (ru) * 2013-03-14 2014-09-18 Общество с ограниченной ответственностью "Тиацен" Cредство для профилактики и/или лечения опухолевых заболеваний
RU2521390C1 (ru) * 2013-03-14 2014-06-27 Общество с ограниченной ответственностью "Тиацен" Производное роданина и средство для профилактики опухолевых заболеваний
US9974795B2 (en) 2014-01-31 2018-05-22 Carna Biosciences, Inc. Anticancer agent composition
EP4083037A4 (en) * 2019-12-26 2024-01-24 Yonsei University, University-Industry Foundation(UIF). Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same
CA3217792A1 (en) 2021-05-07 2022-11-10 Kymera Therapeutics, Inc Cdk2 degraders and uses thereof
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9700696A (es) * 1994-07-27 1997-04-30 Sankyo Co Compuestos heterociclicos, utiles como productores de efecto aloesterico en receptores muscarinicos.
CA2203517A1 (en) 1994-11-10 1996-05-23 Alan M. Laibelman Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
EP0888310B1 (en) 1996-03-15 2005-09-07 AstraZeneca AB Cinnoline derivatives and use as medicine
CN1158269C (zh) 1997-10-27 2004-07-21 阿古龙制药公司 作为cdk抑制剂的取代的4-氨基-噻唑-2-基化合物
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
WO2003028724A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
EP1531813A1 (en) * 2002-07-10 2005-05-25 Applied Research Systems ARS Holding N.V. Use of compounds for increasing spermatozoa motility
MXPA05000453A (es) * 2002-07-10 2005-03-23 Applied Research Systems Derivados de benceno fusionados a azolidinona-vinilo.
US20040214872A1 (en) * 2002-09-26 2004-10-28 Pintex Pharmaceuticals, Inc. Pin1-modulating compounds and methods of use thereof
KR20050085115A (ko) * 2002-11-22 2005-08-29 스미스클라인 비참 코포레이션 신규 화합물

Also Published As

Publication number Publication date
JP2008516903A (ja) 2008-05-22
DE602005005211D1 (de) 2008-04-17
RU2391342C2 (ru) 2010-06-10
EP1805175B1 (en) 2008-03-05
CN100569773C (zh) 2009-12-16
CN101039943A (zh) 2007-09-19
DE602005005211T2 (de) 2009-03-19
KR100875870B1 (ko) 2008-12-26
AU2005293831A1 (en) 2006-04-20
MX2007004273A (es) 2007-05-11
EP1805175A1 (en) 2007-07-11
RU2007117764A (ru) 2008-11-20
US7247727B2 (en) 2007-07-24
KR20070053342A (ko) 2007-05-23
ES2301066T3 (es) 2008-06-16
US20060084674A1 (en) 2006-04-20
CA2582986A1 (en) 2006-04-20
AU2005293831B2 (en) 2011-01-06
PL1805175T3 (pl) 2008-08-29
ATE388149T1 (de) 2008-03-15
WO2006040049A1 (en) 2006-04-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DA 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2208 DE 30/04/2013.