BRPI0518409A2 - combinaÇço de inibidor dpp-iv, antidiabÉtico ppar e metformina - Google Patents

combinaÇço de inibidor dpp-iv, antidiabÉtico ppar e metformina

Info

Publication number
BRPI0518409A2
BRPI0518409A2 BRPI0518409-6A BRPI0518409A BRPI0518409A2 BR PI0518409 A2 BRPI0518409 A2 BR PI0518409A2 BR PI0518409 A BRPI0518409 A BR PI0518409A BR PI0518409 A2 BRPI0518409 A2 BR PI0518409A2
Authority
BR
Brazil
Prior art keywords
ppar
combination
agonists
dpp
inhibitor
Prior art date
Application number
BRPI0518409-6A
Other languages
English (en)
Inventor
Bryan Burkey
Thomas Edward Hughes
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0518409A2 publication Critical patent/BRPI0518409A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMBINAÇçO DE INIBIDOR DPP-IV, ANTIDIABÉTICO PPAR E METFORMINA. A invenção se refere a uma combinação, tal como uma prepara- ção combinada ou uma composição farmacêutica, respectivamente que compreende: i) um inibidor da dipeptidilpeptidase - IV (DPP-IV),(ii) um AN- TIDIABÉTICO PPAR selecionado a partir de tiazolidinadionas (glitazonas), agonistas do tipo não glitazona, agonistas PPAR'y, agonistas PPARcL ou agonistas duplos PPAR'y/ PPARcL, e (iii) meiformina, para uso simultâneo, separado ou em seqúência, especialmente para a prevenção, retardamento da progressão ou o tratamento de condições mediadas pela dipeptidilpeptidase - IV, especificamente do diabetes, mais especificamente do diabetes melito do tipo 2, condições de tolerância prejudicada de glicose (IGT), condições de glicose do plasma prejudicadas por falta, acidose metabólica, cetose, artrite, obesidade e osteoporose; o uso de tal combinação para a preparação de uma preparação farmacêutica para a prevenção, retardamento da progressão ou o tratamento de condições mediadas pela dipeptidilpeptidase - IV, um método para melhorar a aparência corporal de um animal de sangue quente.
BRPI0518409-6A 2004-10-25 2005-10-21 combinaÇço de inibidor dpp-iv, antidiabÉtico ppar e metformina BRPI0518409A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62189104P 2004-10-25 2004-10-25
PCT/US2005/037819 WO2006047248A1 (en) 2004-10-25 2005-10-21 Combination of dpp-iv inhibitor, ppar antidiabetic and metformin

Publications (1)

Publication Number Publication Date
BRPI0518409A2 true BRPI0518409A2 (pt) 2008-11-18

Family

ID=35717718

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518409-6A BRPI0518409A2 (pt) 2004-10-25 2005-10-21 combinaÇço de inibidor dpp-iv, antidiabÉtico ppar e metformina

Country Status (11)

Country Link
US (2) US20090253752A1 (pt)
EP (1) EP1807066A1 (pt)
JP (1) JP2008517921A (pt)
KR (1) KR20070068407A (pt)
CN (1) CN101035522B (pt)
AU (2) AU2005299808B2 (pt)
BR (1) BRPI0518409A2 (pt)
CA (1) CA2581298A1 (pt)
MX (1) MX2007004934A (pt)
RU (1) RU2007119320A (pt)
WO (1) WO2006047248A1 (pt)

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Also Published As

Publication number Publication date
US20110301172A1 (en) 2011-12-08
JP2008517921A (ja) 2008-05-29
EP1807066A1 (en) 2007-07-18
KR20070068407A (ko) 2007-06-29
AU2005299808B2 (en) 2009-08-20
AU2009222515A1 (en) 2009-10-22
US20090253752A1 (en) 2009-10-08
MX2007004934A (es) 2007-06-12
WO2006047248A1 (en) 2006-05-04
CA2581298A1 (en) 2006-05-04
CN101035522B (zh) 2011-12-07
RU2007119320A (ru) 2008-11-27
AU2005299808A1 (en) 2006-05-04
CN101035522A (zh) 2007-09-12

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