BRPI0518565A2 - composiÇÕes cardiovasculares - Google Patents
composiÇÕes cardiovascularesInfo
- Publication number
- BRPI0518565A2 BRPI0518565A2 BRPI0518565-3A BRPI0518565A BRPI0518565A2 BR PI0518565 A2 BRPI0518565 A2 BR PI0518565A2 BR PI0518565 A BRPI0518565 A BR PI0518565A BR PI0518565 A2 BRPI0518565 A2 BR PI0518565A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- cardiovascular
- promote
- health
- maintain
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- 230000002526 effect on cardiovascular system Effects 0.000 title abstract 2
- 230000036996 cardiovascular health Effects 0.000 abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 230000002542 deteriorative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000036541 health Effects 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
COMPOSIÇÕES CARDIOVASCULARES. A presente invenção refere-se a composições que promovem e/ou mantêm a saúde cardiovascular através do tratamento de uma ou mais doenças cardiovasculares. Também são fornecidos métodos para uso de composições que promovem e/ou mantêm a saúde cardiovascular através da prevenção, estabilização, reversão e/ou tratamento de doença arterial coronária e/ou doença cerebrovascular. Tais composições podem ser usadas independentemente para promover e/ou manter a saúde cardiovascular ou usadas em combinação com uma ou mais outras composições usadas no tratamento de vários outros estados de doença comuns ao envelhecimento e/ou a uma condição de deterioração de saúde.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/021,282 US20060135610A1 (en) | 2004-12-22 | 2004-12-22 | Cardiovascular compositions |
| PCT/US2005/038227 WO2006071342A2 (en) | 2004-12-22 | 2005-10-20 | Cardiovascular compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518565A2 true BRPI0518565A2 (pt) | 2008-11-25 |
Family
ID=36596911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518565-3A BRPI0518565A2 (pt) | 2004-12-22 | 2005-10-20 | composiÇÕes cardiovasculares |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060135610A1 (pt) |
| EP (1) | EP1838323A4 (pt) |
| JP (1) | JP2008525441A (pt) |
| CN (1) | CN101123969A (pt) |
| AR (1) | AR052836A1 (pt) |
| AU (1) | AU2005322584A1 (pt) |
| BR (1) | BRPI0518565A2 (pt) |
| CA (1) | CA2594212A1 (pt) |
| MX (1) | MX2007007781A (pt) |
| PE (1) | PE20060764A1 (pt) |
| WO (1) | WO2006071342A2 (pt) |
Families Citing this family (65)
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| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| US7399755B2 (en) * | 2005-02-17 | 2008-07-15 | Premier Micronutrient Corporation | Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same |
| JP5337479B2 (ja) * | 2005-05-04 | 2013-11-06 | プロノヴァ・バイオファーマ・ノルゲ・アーエス | 新規化合物 |
| US20070299017A1 (en) * | 2006-06-23 | 2007-12-27 | Kanter Mitchell M | Compositions for lowering blood serum cholesterol and use in foods, beverages, and health supplements |
| EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
| US20080064702A1 (en) * | 2006-09-08 | 2008-03-13 | Charalambos Antoniades | Use of folates for the prevention and treatment of vascular diseases |
| US7282225B1 (en) | 2006-09-27 | 2007-10-16 | Occular Technologies, Inc. | Composition and methods for improving retinal health |
| RU2507193C2 (ru) * | 2006-11-01 | 2014-02-20 | Пронова Биофарма Норге А/С | Альфа-замещенные омега-3 липиды, которые являются активаторами или модуляторами рецептора, активируемого пролифераторами пероксисом (ppar) |
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| ES2732293T3 (es) * | 2007-02-22 | 2019-11-21 | Childrens Hospital & Res Center At Oakland | Formulaciones de ácidos grasos y métodos para el uso de las mismas |
| KR20100100818A (ko) * | 2007-10-31 | 2010-09-15 | 프로노바 바이오파마 노르지 에이에스 | 새로운 dha 유도체 및 약물로서 그들의 사용 |
| CA2703994C (en) * | 2007-11-06 | 2017-05-23 | The Salk Institute For Biological Studies | Use of vitamin d receptor agonists and precursors to treat fibrosis |
| US8318708B2 (en) * | 2007-11-06 | 2012-11-27 | Salk Institute For Biological Studies | Use of vitamin D receptor agonists, ligands, and precursors to treat pancreatic fibrosis |
| US8586104B2 (en) * | 2008-04-10 | 2013-11-19 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essentially fatty acids derived from Salvia hispanica L. seed: composition of matter, manufacturing process and use |
| US8784904B2 (en) * | 2008-04-10 | 2014-07-22 | U.S. Nutraceuticals, LLC | Plant derived seed extract rich in essential fatty acids derived from perilla seed: composition of matter, manufacturing process and use |
| US8592439B2 (en) * | 2008-08-07 | 2013-11-26 | Spa Societa Prodotti Antibiotici S.P.A. | Long-term treatment of symptomatic heart failure |
| EP3187182B1 (en) | 2008-09-02 | 2021-03-03 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same |
| WO2010064665A1 (ja) * | 2008-12-01 | 2010-06-10 | 辻堂化学株式会社 | 治療剤 |
| CN102239414A (zh) * | 2008-12-04 | 2011-11-09 | 赛诺菲-安万特 | 牵涉血红素结合蛋白1的方法和用途 |
| RU2505292C2 (ru) | 2009-02-10 | 2014-01-27 | Амарин Фармасьютикалз Айрлэнд Лимитед | Способы лечения гипертриглицеридемии |
| US20100239660A1 (en) * | 2009-03-19 | 2010-09-23 | Doughman Scott D | Product and use of omega-3s matching human tissue ratios for treatment of inflammatory and other conditions |
| MX377553B (es) | 2009-04-29 | 2025-03-10 | Amarin Pharma Inc | Composicion farmaceutica estable y metodos de uso de la misma. |
| CN107233337A (zh) | 2009-04-29 | 2017-10-10 | 阿马里纳药物爱尔兰有限公司 | 含有epa和心血管剂的药物组合物以及使用其的方法 |
| BRPI1011883A2 (pt) * | 2009-06-15 | 2016-09-13 | Amarin Pharma Inc | uso de composições para redução de triglicerídeos sem elevar os níveis de o ldl-c em um paciente sob o tratamento concomitante com estatina |
| NZ599061A (en) | 2009-09-23 | 2014-05-30 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| CA3066588C (en) * | 2010-03-04 | 2022-03-22 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating and/or preventing cardiovascular disease |
| US8563267B2 (en) * | 2010-07-22 | 2013-10-22 | Asia-Pacific Beiotech Developing, Inc. | Lycogen extract, composition thereof and method for the treatment using the same |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| NZ744990A (en) | 2010-11-29 | 2019-10-25 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US10709680B2 (en) * | 2011-07-18 | 2020-07-14 | Physicians Recommended Nutriceuticals, Llc | Methods for treating dry eye |
| WO2013070735A1 (en) | 2011-11-07 | 2013-05-16 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| EP2800469B1 (en) | 2012-01-06 | 2021-08-25 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject |
| US9603826B2 (en) | 2012-06-29 | 2017-03-28 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of a cardiovascular event in a subject on statin therapy |
| CN102901788B (zh) * | 2012-08-31 | 2014-09-10 | 江苏省农业科学院 | 叶黄素二琥珀酸酯的测定方法 |
| WO2014074552A2 (en) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
| US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
| US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| AU2014257051A1 (en) | 2013-04-24 | 2015-11-19 | Salk Institute For Biological Studies | Vitamin D receptor/SMAD genomic circuit gates fibrotic response |
| BR112015030518A2 (pt) | 2013-06-05 | 2017-08-29 | Salk Inst For Biological Studi | Composição farmacêutica, uso de um ou mais agonistas do receptor da vitamina d (vdr), e, método para a redução da atividade biológica do ligante 12 do motivo c-x-c (cxcl12) |
| US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
| US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| ES2813383T3 (es) * | 2013-12-19 | 2021-03-23 | Tassos Georgiou | Composición de ácidos grasos omega 3 para tratar enfermedades que implican daños en el sistema nervioso |
| JP6614581B2 (ja) * | 2014-03-17 | 2019-12-04 | 三菱商事ライフサイエンス株式会社 | リン脂質型αリノレン酸含有組成物 |
| US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
| WO2015195662A1 (en) | 2014-06-16 | 2015-12-23 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| CN104940933A (zh) * | 2015-06-15 | 2015-09-30 | 青岛大学附属医院 | 一种用于预防治疗心血管疾病的药物 |
| WO2017055611A2 (en) * | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
| US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
| US11978543B2 (en) * | 2016-12-14 | 2024-05-07 | Astarte Medical Partners Inc. | System and methods for developing and using a microbiome-based action component |
| US10966951B2 (en) | 2017-05-19 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject having reduced kidney function |
| WO2019023149A1 (en) | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES |
| US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
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| WO2020138556A1 (ko) * | 2018-12-28 | 2020-07-02 | 경상대학교병원 | 혈관 확장 감소 억제용 의약 조성물 |
| CA3160676A1 (en) | 2019-11-12 | 2021-05-20 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter |
| US11986452B2 (en) | 2021-04-21 | 2024-05-21 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
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-
2004
- 2004-12-22 US US11/021,282 patent/US20060135610A1/en not_active Abandoned
-
2005
- 2005-10-20 WO PCT/US2005/038227 patent/WO2006071342A2/en not_active Ceased
- 2005-10-20 MX MX2007007781A patent/MX2007007781A/es not_active Application Discontinuation
- 2005-10-20 JP JP2007548205A patent/JP2008525441A/ja active Pending
- 2005-10-20 CA CA002594212A patent/CA2594212A1/en not_active Abandoned
- 2005-10-20 AU AU2005322584A patent/AU2005322584A1/en not_active Abandoned
- 2005-10-20 BR BRPI0518565-3A patent/BRPI0518565A2/pt not_active IP Right Cessation
- 2005-10-20 EP EP05817075A patent/EP1838323A4/en not_active Withdrawn
- 2005-10-20 CN CNA2005800485514A patent/CN101123969A/zh active Pending
- 2005-12-16 PE PE2005001480A patent/PE20060764A1/es not_active Application Discontinuation
- 2005-12-21 AR ARP050105441A patent/AR052836A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060135610A1 (en) | 2006-06-22 |
| AU2005322584A1 (en) | 2006-07-06 |
| PE20060764A1 (es) | 2006-08-16 |
| EP1838323A4 (en) | 2008-06-18 |
| MX2007007781A (es) | 2007-08-22 |
| CA2594212A1 (en) | 2006-07-06 |
| WO2006071342A2 (en) | 2006-07-06 |
| EP1838323A2 (en) | 2007-10-03 |
| WO2006071342A3 (en) | 2007-08-09 |
| AR052836A1 (es) | 2007-04-04 |
| CN101123969A (zh) | 2008-02-13 |
| JP2008525441A (ja) | 2008-07-17 |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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