BRPI0612119A2 - tratamento de distúrbio auto-imunes com uma neuroxotina - Google Patents

tratamento de distúrbio auto-imunes com uma neuroxotina Download PDF

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Publication number
BRPI0612119A2
BRPI0612119A2 BRPI0612119-5A BRPI0612119A BRPI0612119A2 BR PI0612119 A2 BRPI0612119 A2 BR PI0612119A2 BR PI0612119 A BRPI0612119 A BR PI0612119A BR PI0612119 A2 BRPI0612119 A2 BR PI0612119A2
Authority
BR
Brazil
Prior art keywords
administering
neurotoxin
treatment
autoimmune disorder
neuroxotine
Prior art date
Application number
BRPI0612119-5A
Other languages
English (en)
Inventor
Schaack Pamela D Van
Kenneth L Tong
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0612119A2 publication Critical patent/BRPI0612119A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

TRATAMENTO DE DISTURBIOS AUTO-IMUNES COM UMA NEUROTOXINA. A presente invenção refere-se a métodos de tratamento de um ou mais distúrbios auto-imunes incluindo uma etapa de administrar uma neurotoxina clostrídica, tal como uma toxina botulínica, a um paciente que tenha um distúrbio auto-imune. Em um aspecto, um método inclui uma etapa de administrar a neurotoxina à glândula timo ou próxima da glândula timo do paciente. Em um outro aspecto, um método inclui uma etapa de administrar a neurotoxina em combinação com a administração de um inibidor de citoquinas ao paciente. As composições também são descritas.
BRPI0612119-5A 2005-06-17 2006-05-31 tratamento de distúrbio auto-imunes com uma neuroxotina BRPI0612119A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/156,502 US8105611B2 (en) 2005-06-17 2005-06-17 Treatment of autoimmune disorder with a neurotoxin
PCT/US2006/021069 WO2006138059A2 (en) 2005-06-17 2006-05-31 Treatment of autoimmune disorders with a neurotoxin

Publications (1)

Publication Number Publication Date
BRPI0612119A2 true BRPI0612119A2 (pt) 2010-10-19

Family

ID=37441984

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0612119-5A BRPI0612119A2 (pt) 2005-06-17 2006-05-31 tratamento de distúrbio auto-imunes com uma neuroxotina

Country Status (7)

Country Link
US (2) US8105611B2 (pt)
EP (2) EP1890714B1 (pt)
JP (2) JP5594962B2 (pt)
AU (1) AU2006259728B2 (pt)
BR (1) BRPI0612119A2 (pt)
CA (2) CA2809723A1 (pt)
WO (1) WO2006138059A2 (pt)

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Also Published As

Publication number Publication date
AU2006259728A1 (en) 2006-12-28
JP2013060450A (ja) 2013-04-04
WO2006138059A2 (en) 2006-12-28
WO2006138059A3 (en) 2007-05-31
EP2452692A1 (en) 2012-05-16
US20060286127A1 (en) 2006-12-21
CA2603141A1 (en) 2006-12-28
US8105611B2 (en) 2012-01-31
CA2809723A1 (en) 2006-12-28
JP2008543833A (ja) 2008-12-04
AU2006259728B2 (en) 2011-11-10
JP5594962B2 (ja) 2014-09-24
US20120093827A1 (en) 2012-04-19
EP1890714A2 (en) 2008-02-27
EP1890714B1 (en) 2012-10-31

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