BRPI0518636A2 - kits nço-radioativo liofilizado e de multi-doses, processo para a preparaÇço de méltiplas doses de paciente unitÁrias do radiofarmacÊutico tetrofosmina-99mtc, composiÇço radiofarmacÊutica estabilizada, e, dose de paciente unitÁria do radiofarmacÊutico tetrofosmina-99mtc - Google Patents
kits nço-radioativo liofilizado e de multi-doses, processo para a preparaÇço de méltiplas doses de paciente unitÁrias do radiofarmacÊutico tetrofosmina-99mtc, composiÇço radiofarmacÊutica estabilizada, e, dose de paciente unitÁria do radiofarmacÊutico tetrofosmina-99mtcInfo
- Publication number
- BRPI0518636A2 BRPI0518636A2 BRPI0518636-6A BRPI0518636A BRPI0518636A2 BR PI0518636 A2 BRPI0518636 A2 BR PI0518636A2 BR PI0518636 A BRPI0518636 A BR PI0518636A BR PI0518636 A2 BRPI0518636 A2 BR PI0518636A2
- Authority
- BR
- Brazil
- Prior art keywords
- radiopharmaceutical
- 99mtc
- tetrophosmin
- preparation
- dose
- Prior art date
Links
- 229940121896 radiopharmaceutical Drugs 0.000 title abstract 4
- 239000012217 radiopharmaceutical Substances 0.000 title abstract 4
- 230000002799 radiopharmaceutical effect Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000002285 radioactive effect Effects 0.000 title 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 4
- 229960004113 tetrofosmin Drugs 0.000 abstract 3
- 235000010323 ascorbic acid Nutrition 0.000 abstract 2
- 239000011668 ascorbic acid Substances 0.000 abstract 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 229940072107 ascorbate Drugs 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 229940124553 radioprotectant Drugs 0.000 abstract 1
- QCWJONLQSHEGEJ-UHFFFAOYSA-N tetrofosmin Chemical compound CCOCCP(CCOCC)CCP(CCOCC)CCOCC QCWJONLQSHEGEJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Saccharide Compounds (AREA)
- Lock And Its Accessories (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Noodles (AREA)
- Train Traffic Observation, Control, And Security (AREA)
- Devices For Supply Of Signal Current (AREA)
Abstract
KITS NçO-RADIOATIVO LIOFILIZADO E DE MULTI-DOSES, PROCESSO PARA A PREPARAÇçO DE MéLTIPLAS DOSES DE PACIENTE UNITÁRIAS DO RADIOFARMACÊUTICO TETROFOSMINA ^ 99m^ TC, COMPOSIÇçO RADIOFARMACÊUTICA ESTABILIZADA, E, DOSE DE PACIENTE UNITÁRIA DO RADIOFARMACÊUTICO TETROFOSMINA ^ 99m^TC A presente invenção refere-se a composições radiofarmaeêuticas ^ 99m^Tce estabilizadas da tetrofosmina de ligando, que incluem um ácido ascórbico ou radioprotetor de ascorbato, na ausência de um conservante antimicrobiano. A invenção também fornece kits liofilizados, adequados para a preparação em massa de múltiplas doses unitárias de paciente de complexos metálicos de ^ 99m^ Tc-tetrofosmina. São também descritas doses unitárias de ^ 99m^Tc-teftofosmina, junto com processos para preparar tais doses unitárias do frasco de massa liofihizada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0427392.6A GB0427392D0 (en) | 2004-12-15 | 2004-12-15 | Stabilised 99mTc compositions |
| PCT/GB2005/003975 WO2006064175A1 (en) | 2004-12-15 | 2005-10-14 | STABILISED 99mTC COMPOSITIONS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0518636A2 true BRPI0518636A2 (pt) | 2008-12-02 |
| BRPI0518636B1 BRPI0518636B1 (pt) | 2016-12-13 |
| BRPI0518636B8 BRPI0518636B8 (pt) | 2021-07-27 |
Family
ID=34090037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518636A BRPI0518636B8 (pt) | 2004-12-15 | 2005-10-14 | kits não-radioativo liofilizado de multi-doses, e, processo para a preparação de múltiplas doses de paciente unitárias do radiofarmacêutico tetrofosmina- 99m tc" |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9694092B2 (pt) |
| EP (1) | EP1824525B1 (pt) |
| JP (1) | JP5064236B2 (pt) |
| KR (1) | KR101297523B1 (pt) |
| CN (2) | CN103028123A (pt) |
| AT (1) | ATE392218T1 (pt) |
| AU (1) | AU2005315503B2 (pt) |
| BR (1) | BRPI0518636B8 (pt) |
| CA (1) | CA2590620C (pt) |
| DE (1) | DE602005006157T2 (pt) |
| ES (1) | ES2306219T3 (pt) |
| GB (1) | GB0427392D0 (pt) |
| MX (1) | MX2007007223A (pt) |
| NO (1) | NO340538B1 (pt) |
| PL (1) | PL1824525T3 (pt) |
| RU (1) | RU2403067C2 (pt) |
| WO (1) | WO2006064175A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2654369C (en) * | 2006-06-21 | 2014-10-14 | Ge Healthcare Limited | Radiopharmaceutical products |
| US20100056826A1 (en) * | 2006-11-09 | 2010-03-04 | Nihon Medi-Physicis Co., Ltd. | Radioactive diagnostic imaging agent |
| GB0718386D0 (en) * | 2007-09-21 | 2007-10-31 | Ge Healthcare As | Improved radiopharmaceutical formulation |
| RU2463075C1 (ru) * | 2011-07-01 | 2012-10-10 | Российская Федерация, От Имени Которой Выступает Министерство Образования И Науки Российской Федерации | СПОСОБ ПОЛУЧЕНИЯ МЕЧЕННОГО ТЕХНЕЦИЕМ-99m НАНОКОЛЛОИДА |
| RU2512595C1 (ru) * | 2013-01-09 | 2014-04-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт онкологии" Сибирского отделения Российской академии медицинских наук (ФГБУ "НИИ онкологии" СО РАМН) | СПОСОБ ПОЛУЧЕНИЯ РЕАГЕНТА ДЛЯ ПРИГОТОВЛЕНИЯ МЕЧЕННОГО ТЕХНЕЦИЕМ 99-m НАНОКОЛЛОИДА НА ОСНОВЕ ГАММА-ОКСИДА АЛЮМИНИЯ |
| RU2543654C1 (ru) * | 2013-11-29 | 2015-03-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Национальный исследовательский Томский политехнический университет" | СПОСОБ ПОЛУЧЕНИЯ МЕЧЕННОГО ТЕХНЕЦИЕМ-99m НАНОКОЛЛОИДА |
| EP2899195A1 (en) | 2014-01-28 | 2015-07-29 | ROTOP Pharmaka AG | Stabilized form of Tetrofosmin and its use |
| WO2017059092A1 (en) | 2015-09-30 | 2017-04-06 | Duke University | Ascorbate formulations and methods of use as contrast agents |
| IT201600101875A1 (it) * | 2016-10-11 | 2018-04-11 | Advanced Accelerator Applications Int S A | Composizioni liofilizzate comprendenti rhAnnexin V-128, processo per la loro preparazione e loro uso per la preparazione di formulazioni contenenti 99mTc-rhAnnexin V-128 |
| KR20190128545A (ko) * | 2017-03-08 | 2019-11-18 | 주빌런트 제네릭스 리미티드(포멀리 어 디비젼 오브 주빌런트 라이프 사이언시스 리미티드) | 테트로포스민 또는 그것의 산 부가 염의 제조를 위한 개선된 과정 |
| BR112020005243A2 (pt) * | 2017-11-23 | 2020-09-24 | Jubilant Generics Limited (Formerly A Division Of Jubilant Life Sciences Limited) | composição farmacêutica compreendendo tetrofosmina e sais farmaceuticamente aceitáveis da mesma |
| BR112020005524A2 (pt) * | 2018-10-06 | 2020-10-06 | Jubilant Generics Limited | composições farmacêuticas de enxofre coloidal e processos das mesmas |
| CN116059409A (zh) * | 2022-12-01 | 2023-05-05 | 程毓渡 | 一种新型心脏造影和评价心室的锝-99m治疗诊断剂及评价方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA761944B (en) | 1975-04-30 | 1977-03-30 | Procter & Gamble | Stable radiographic scanning agents |
| JPS5750928A (en) * | 1980-09-13 | 1982-03-25 | Nippon Mejifuijitsukusu Kk | Diagnostic agent for scanning bone |
| JPS5896031A (ja) * | 1981-12-03 | 1983-06-07 | Nippon Mejifuijitsukusu Kk | 放射性診断剤およびその製造用組成物 |
| GB8808414D0 (en) * | 1988-04-11 | 1988-05-11 | Amersham Int Plc | Ligands & cationic complexes thereof with technetium-99m |
| JP2860157B2 (ja) | 1990-10-31 | 1999-02-24 | 日本メジフィジックス株式会社 | 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法 |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| EP1197227B9 (en) * | 1999-06-21 | 2008-06-11 | Nihon Medi-Physics Co., Ltd. | Method of the administration of drugs having binding affinity with plasma protein and preparation to be used in the method |
| CN1184225C (zh) * | 2000-06-28 | 2005-01-12 | 北京师范大学 | 一种替曲膦季鏻盐及其制法和二步法替曲膦药盒及其应用 |
| GB0031592D0 (en) * | 2000-12-28 | 2001-02-07 | Nycomed Amersham Plc | Stabilised radiopharmaceutical compositions |
| CZ20032597A3 (cs) * | 2001-02-26 | 2004-12-15 | Bristol-Myers Squibb Pharma Company | Analogy kyseliny askorbové pro metaloradiofarmaceutika |
| GB0116815D0 (en) * | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
-
2004
- 2004-12-15 GB GBGB0427392.6A patent/GB0427392D0/en not_active Ceased
-
2005
- 2005-10-14 ES ES05794253T patent/ES2306219T3/es not_active Expired - Lifetime
- 2005-10-14 RU RU2007120467/15A patent/RU2403067C2/ru active
- 2005-10-14 US US11/721,064 patent/US9694092B2/en active Active
- 2005-10-14 WO PCT/GB2005/003975 patent/WO2006064175A1/en not_active Ceased
- 2005-10-14 CN CN2012104649695A patent/CN103028123A/zh active Pending
- 2005-10-14 MX MX2007007223A patent/MX2007007223A/es active IP Right Grant
- 2005-10-14 DE DE602005006157T patent/DE602005006157T2/de not_active Expired - Lifetime
- 2005-10-14 AU AU2005315503A patent/AU2005315503B2/en not_active Ceased
- 2005-10-14 EP EP05794253A patent/EP1824525B1/en not_active Expired - Lifetime
- 2005-10-14 BR BRPI0518636A patent/BRPI0518636B8/pt not_active IP Right Cessation
- 2005-10-14 AT AT05794253T patent/ATE392218T1/de not_active IP Right Cessation
- 2005-10-14 KR KR1020077013340A patent/KR101297523B1/ko not_active Expired - Fee Related
- 2005-10-14 JP JP2007546154A patent/JP5064236B2/ja not_active Expired - Lifetime
- 2005-10-14 PL PL05794253T patent/PL1824525T3/pl unknown
- 2005-10-14 CN CNA2005800430653A patent/CN101107017A/zh active Pending
- 2005-10-14 CA CA2590620A patent/CA2590620C/en not_active Expired - Lifetime
-
2007
- 2007-06-20 NO NO20073158A patent/NO340538B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN103028123A (zh) | 2013-04-10 |
| NO340538B1 (no) | 2017-05-02 |
| BRPI0518636B8 (pt) | 2021-07-27 |
| BRPI0518636B1 (pt) | 2016-12-13 |
| CA2590620C (en) | 2012-12-04 |
| EP1824525B1 (en) | 2008-04-16 |
| MX2007007223A (es) | 2007-08-14 |
| RU2007120467A (ru) | 2009-01-27 |
| PL1824525T3 (pl) | 2008-11-28 |
| KR20070089156A (ko) | 2007-08-30 |
| WO2006064175A1 (en) | 2006-06-22 |
| CN101107017A (zh) | 2008-01-16 |
| AU2005315503A1 (en) | 2006-06-22 |
| CA2590620A1 (en) | 2006-06-22 |
| US9694092B2 (en) | 2017-07-04 |
| GB0427392D0 (en) | 2005-01-19 |
| AU2005315503B2 (en) | 2011-06-02 |
| DE602005006157D1 (de) | 2008-05-29 |
| DE602005006157T2 (de) | 2009-05-28 |
| KR101297523B1 (ko) | 2013-08-16 |
| JP2008524178A (ja) | 2008-07-10 |
| US20110008252A9 (en) | 2011-01-13 |
| ES2306219T3 (es) | 2008-11-01 |
| RU2403067C2 (ru) | 2010-11-10 |
| US20090311178A1 (en) | 2009-12-17 |
| EP1824525A1 (en) | 2007-08-29 |
| ATE392218T1 (de) | 2008-05-15 |
| JP5064236B2 (ja) | 2012-10-31 |
| NO20073158L (no) | 2007-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20073158L (no) | Stabiliserte 99mTC-sammensetninger | |
| TNSN07341A1 (en) | Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer | |
| MX2007002398A (es) | Nuevas composiciones farmaceuticas para el tratamiento de cancer. | |
| MY141025A (en) | Dose forms | |
| EA200700501A1 (ru) | Композиция (варианты) и способ для лечения гиперпролиферативных процессов, способ лечения рака (варианты) и способ получения твёрдой дисперсии вещества | |
| BRPI0507684B8 (pt) | agentes de contraste para imagem de perfusão miocárdica | |
| BRPI0607809A2 (pt) | uso de uma composição compreendendo nanopartìculas, composição e kit | |
| BR112013015786A2 (pt) | composição de agente de formação de imagem, método de formação de imagem de pelo menos uma parte de um indivíduo, e, método para preparar uma composição de polipeptídeo conjugado com quelante | |
| MX2007009649A (es) | Derivados de meleimida, composiciones farmaceuticas y metodos para el tratamiento del cancer. | |
| BRPI0508579A (pt) | composto, composição farmacêutica, e, uso de um composto | |
| MY163136A (en) | Peptide radiotracer compositions | |
| WO2007042781A3 (en) | Automated method for preparing technetium complexes | |
| MX2009011493A (es) | Complejo de excipiente farmaceutico. | |
| BRPI0313764A2 (pt) | método de preparação de composições de inalação de pó seco | |
| EA200601524A1 (ru) | Альфа-излучающие частицы гидроксиапатита | |
| TW200730532A (en) | Camptothecin derivatives as chemoradiosensitizing agents | |
| WO2009013358A3 (en) | Polysaccharides grafted by polyamines for the preparation of radiopharmaceutical compositions | |
| MX2012012479A (es) | Metodos, composiciones y accesorios para proporcionar un tratamiento terapeutico. | |
| TW200718698A (en) | Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof | |
| UA87312C2 (ru) | КОМПОЗИЦИЯ ДЛЯ АЭРОЗОЛЬНОЙ ИНГАЛЯЦИИ β-АГОНИСТОВ | |
| PL1720540T3 (pl) | Satraplatyna do leczenia odpornych i opornych nowotworów | |
| ATE287716T1 (de) | Metallsalze als antimykotika | |
| GB0403856D0 (en) | Composition | |
| TW200720239A (en) | Styrylsulfonamides, their manufacture and use as pharmaceutical agents | |
| ATE521591T1 (de) | 11c-markierte benzyl-lactam-verbindungen und deren verwendung als bildgebungsmittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/12/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/10/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2692 DE 09-08-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |