BRPI0519198A2 - moduladores de delta-opiàide tricÍclicos - Google Patents

moduladores de delta-opiàide tricÍclicos

Info

Publication number
BRPI0519198A2
BRPI0519198A2 BRPI0519198-0A BRPI0519198A BRPI0519198A2 BR PI0519198 A2 BRPI0519198 A2 BR PI0519198A2 BR PI0519198 A BRPI0519198 A BR PI0519198A BR PI0519198 A2 BRPI0519198 A2 BR PI0519198A2
Authority
BR
Brazil
Prior art keywords
opioid
tricyclic
modulators
delta
opioid modulators
Prior art date
Application number
BRPI0519198-0A
Other languages
English (en)
Inventor
John R Carson
Scott L Dax
Bart Decorte
Li Liu
James J Mcnally
Mark Mcdonnell
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0519198A2 publication Critical patent/BRPI0519198A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

MODULADORES DE DELTA-OPIàIDE TRICÍCLICOS. A invenção refere-se a moduladores de receptor deita opiálde da fórmula (1). Mais especificamente, a invenção refere-se a moduladores <sym>-opióide triçíclicos. Composições farmacêuticas e veterinárias para tratar dor branda a severa e várias doenças que são também descritas.
BRPI0519198-0A 2004-12-22 2005-12-21 moduladores de delta-opiàide tricÍclicos BRPI0519198A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63831404P 2004-12-22 2004-12-22
PCT/US2005/046690 WO2006069275A1 (en) 2004-12-22 2005-12-21 Tricyclic delta-opioid modulators

Publications (1)

Publication Number Publication Date
BRPI0519198A2 true BRPI0519198A2 (pt) 2008-12-30

Family

ID=36177990

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519198-0A BRPI0519198A2 (pt) 2004-12-22 2005-12-21 moduladores de delta-opiàide tricÍclicos

Country Status (10)

Country Link
US (2) US20060135522A1 (pt)
EP (1) EP1836196A1 (pt)
JP (1) JP2008525481A (pt)
KR (1) KR20070092286A (pt)
CN (1) CN101128458A (pt)
AU (1) AU2005319059A1 (pt)
BR (1) BRPI0519198A2 (pt)
CA (1) CA2592462A1 (pt)
MX (1) MX2007007625A (pt)
WO (1) WO2006069275A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589103B2 (en) 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
CA2574768A1 (en) * 2004-08-05 2006-02-05 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
MX2007007626A (es) 2004-12-22 2008-01-28 Johnson & Johnson Moduladores delta-opioides triciclicos.
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
US7432257B2 (en) * 2005-01-06 2008-10-07 Janssen Pharmaceutica N.V. Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators
CA2612491A1 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
IT1396951B1 (it) 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
KR101275092B1 (ko) * 2011-05-19 2013-06-17 한미정밀화학주식회사 아질사르탄의 개선된 제조방법
CN102680310A (zh) * 2012-03-20 2012-09-19 中国人民解放军第二军医大学 一种微波辅助血浆样品前处理方法及在血浆代谢组学分析中的应用
WO2016116527A1 (de) * 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108069935A (zh) * 2017-12-25 2018-05-25 天津瑞岭化工有限公司 一种2,4-二乙基硫杂蒽酮的制备方法
CN115521319A (zh) * 2021-06-25 2022-12-27 沈阳兴齐眼药股份有限公司 2-(10-氧代-9-氧杂-1-氮杂蒽-6-基)丙酸酯类化合物的制备方法及用途
CN115521320B (zh) * 2021-06-25 2023-09-05 沈阳兴齐眼药股份有限公司 一种制备普拉洛芬的方法

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US2386006A (en) * 1943-09-09 1945-10-02 New York Air Brake Co Sander
US2368006A (en) * 1943-10-07 1945-01-23 Searle & Co Heterocyclic tertiary amines
US2784185A (en) * 1953-03-27 1957-03-05 Promonta Chem Fab Phenothiazine compounds
US2901478A (en) * 1957-02-11 1959-08-25 Promonta Chem Fab Phenothiazine compounds
US3179665A (en) * 1959-12-16 1965-04-20 Wander Ag Dr A 9-(n-ethyl and n-propyl piperidyl-3'-methyl)-thioxanthenes
DE1159954B (de) * 1961-11-25 1963-12-27 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 10-(Alkoxypiperidinopropyl)-phenthiazine und ihrer Salze
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
NL6818027A (pt) * 1968-01-09 1969-07-11
US3987042A (en) * 1969-03-03 1976-10-19 Claude Gueremy Phenothiazine derivative
US3931232A (en) * 1974-06-24 1976-01-06 Smithkline Corporation 3-Alkyl xanthene compounds
US4086350A (en) * 1974-11-06 1978-04-25 Smithkline Corporation Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
ZA756550B (en) * 1974-11-06 1976-09-29 Smithkline Corp Pharmaceutical compositions and method of producing antipsychotic activity without extrapyramidal symptoms
US4285956A (en) * 1978-05-12 1981-08-25 Kefalas A/S Xanthene and thioxanthene derivatives, compositions thereof and treatment therewith
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4666907A (en) * 1983-10-05 1987-05-19 Merck Frosst Canada, Inc. Phenothiazine and derivatives and analogs and use as leukotriene biosynthesis inhibitors
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
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WO2004035541A1 (en) * 2002-10-15 2004-04-29 Janssen Pharmaceutica, N.V. Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
US7589103B2 (en) * 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
CA2574768A1 (en) * 2004-08-05 2006-02-05 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
MX2007007626A (es) * 2004-12-22 2008-01-28 Johnson & Johnson Moduladores delta-opioides triciclicos.
US7432257B2 (en) * 2005-01-06 2008-10-07 Janssen Pharmaceutica N.V. Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators
CA2612491A1 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators

Also Published As

Publication number Publication date
MX2007007625A (es) 2008-01-28
KR20070092286A (ko) 2007-09-12
JP2008525481A (ja) 2008-07-17
CN101128458A (zh) 2008-02-20
US20080306111A1 (en) 2008-12-11
WO2006069275A1 (en) 2006-06-29
CA2592462A1 (en) 2006-06-29
AU2005319059A1 (en) 2006-06-29
US20060135522A1 (en) 2006-06-22
EP1836196A1 (en) 2007-09-26

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.