BRPI0513075A - moduladores gama-opióides tricìclicos - Google Patents

moduladores gama-opióides tricìclicos

Info

Publication number
BRPI0513075A
BRPI0513075A BRPI0513075-1A BRPI0513075A BRPI0513075A BR PI0513075 A BRPI0513075 A BR PI0513075A BR PI0513075 A BRPI0513075 A BR PI0513075A BR PI0513075 A BRPI0513075 A BR PI0513075A
Authority
BR
Brazil
Prior art keywords
modulators
tricyclic
opioid
opioid modulators
relates
Prior art date
Application number
BRPI0513075-1A
Other languages
English (en)
Inventor
Scott L Dax
Bart Decorte
Li Liu
Mark Mcdonnell
James J Mcnally
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0513075A publication Critical patent/BRPI0513075A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

MODULADORES GAMA-OPIóIDES TRICìCLICOS. A presente invenção refere-se a moduladores de receptar deita opióides. Mais especificamente, a invenção refere-se a moduladores <sym>-opióides tricíclicos. São também descritas composições farmacêuticas e veterinárias e métodos de tratar dor branda à severa e várias doenças empregando-se compostos da invenção.
BRPI0513075-1A 2004-08-05 2005-08-02 moduladores gama-opióides tricìclicos BRPI0513075A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59913104P 2004-08-05 2004-08-05
PCT/US2005/027568 WO2007030089A1 (en) 2004-08-05 2005-08-02 Tricyclic delta- opioid modulators

Publications (1)

Publication Number Publication Date
BRPI0513075A true BRPI0513075A (pt) 2008-04-22

Family

ID=37075386

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513075-1A BRPI0513075A (pt) 2004-08-05 2005-08-02 moduladores gama-opióides tricìclicos

Country Status (17)

Country Link
US (2) US7553850B2 (pt)
EP (1) EP1910353A1 (pt)
JP (1) JP2008529971A (pt)
KR (1) KR20080027216A (pt)
CN (1) CN101039940A (pt)
AR (1) AR050198A1 (pt)
AU (1) AU2005335481A1 (pt)
BR (1) BRPI0513075A (pt)
CA (1) CA2574768A1 (pt)
EA (1) EA200700403A1 (pt)
EC (1) ECSP077230A (pt)
IL (1) IL181120A0 (pt)
NI (1) NI200700030A (pt)
NO (1) NO20071208L (pt)
TW (1) TW200621767A (pt)
WO (1) WO2007030089A1 (pt)
ZA (1) ZA200701875B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7589103B2 (en) 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
CA2574768A1 (en) 2004-08-05 2006-02-05 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
MX2007007626A (es) 2004-12-22 2008-01-28 Johnson & Johnson Moduladores delta-opioides triciclicos.
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
US7432257B2 (en) * 2005-01-06 2008-10-07 Janssen Pharmaceutica N.V. Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators
CA2612491A1 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators
AU2006272773B2 (en) * 2005-07-21 2012-03-08 Rensselaer Polytechnic Institute 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents
CA2840643C (en) 2011-06-29 2017-11-21 Alkermes, Inc. Peripherally acting opioid compounds
EP3535243B1 (en) 2016-11-04 2021-12-15 Auckland Uniservices Limited Substituted 9h-xanthen-9-one, 9h-thioxanthen-9-one and acridin-9(10h)-one derivatives and related compounds csf-1r inhibitors for the treatment of cancer
EP3824349A1 (en) 2018-07-19 2021-05-26 Lintfield Limited Thioxanthone derivatives, composition comprising the same and pattern forming method comprising said composition

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CA2574768A1 (en) 2004-08-05 2006-02-05 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
MX2007007626A (es) * 2004-12-22 2008-01-28 Johnson & Johnson Moduladores delta-opioides triciclicos.
EP1836196A1 (en) * 2004-12-22 2007-09-26 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
CN101119992A (zh) * 2004-12-22 2008-02-06 詹森药业有限公司 三环δ阿片样物质调节剂
US7432257B2 (en) * 2005-01-06 2008-10-07 Janssen Pharmaceutica N.V. Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators
CA2612491A1 (en) * 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V. Tricyclic opioid modulators

Also Published As

Publication number Publication date
EP1910353A1 (en) 2008-04-16
CN101039940A (zh) 2007-09-19
CA2574768A1 (en) 2006-02-05
NI200700030A (es) 2008-02-04
EA200700403A1 (ru) 2007-08-31
US20060030585A1 (en) 2006-02-09
WO2007030089A8 (en) 2007-05-31
US7553850B2 (en) 2009-06-30
IL181120A0 (en) 2008-03-20
US20090291979A1 (en) 2009-11-26
TW200621767A (en) 2006-07-01
AU2005335481A8 (en) 2008-12-11
KR20080027216A (ko) 2008-03-26
NO20071208L (no) 2007-04-19
AU2005335481A1 (en) 2007-04-19
AR050198A1 (es) 2006-10-04
JP2008529971A (ja) 2008-08-07
ECSP077230A (es) 2007-04-26
WO2007030089A1 (en) 2007-03-15
ZA200701875B (en) 2008-07-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.